Association between anti-Mullerian hormone and insulin resistance in non-obese adolescent females with polycystic ovary syndrome

Tokmak, Aytekin; Kokanalı, Demet; Tımur, Hakan; Kokanali, Mahmut Kuntay; Yılmaz, Nafiye

doi:10.1080/09513590.2016.1193140

Cited by 23 publications

(20 citation statements)

References 35 publications

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“…Increased levels of insulin have been shown to cause both a surge in LH and increased androgen release from the theca cells through the ovarian insulin receptors in women with PCOS. Finally, the clinical picture involves the appearance of hyperandrogenaemia, one of the symptoms of PCOS [21920]. However, the relationship between fetuin-A and IR remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Although figures vary according to the diagnostic criteria, its incidence is reported to be 6% to 20% [123]. Acne, hirsutism, seborrhoea, menstrual irregularities, anovulation, infertility, obesity, and several metabolic (e.g., glucose and lipid abnormalities) and atherosclerotic disorders are among the symptoms and signs of this disease [45].…”

Section: Introductionmentioning

confidence: 99%

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Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak

Uyanıkoğlu

Incebiyik

et al. 2018

Clin Exp Reprod Med

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ObjectiveThe aim of this study was to compare serum fetuin-A levels and oxidative stress markers, as indicators of insulin resistance, in women with polycystic ovary syndrome (PCOS) and in healthy controls.MethodsThis prospective case-control study included 46 patients with PCOS and 48 age- and body mass index–matched control women. Levels of serum hormones, fetuin-A, and oxidative stress markers were measured in blood samples taken during the early follicular period from each participant.ResultsFollicle-stimulating hormone (FSH), luteinising hormone (LH), total testosterone levels, and the LH/FSH ratio were found to be significantly higher in women with PCOS than in controls. Serum total antioxidant status, total oxidant status, and oxidative stress index parameters all indicated significantly higher levels of oxidative stress in PCOS patients than in controls. Serum fetuin-A levels, which were analyzed as an indicator of insulin resistance, were higher in the PCOS group than in the control group (210.26±65.06 µg/mL and 182.68±51.20 µg/mL, respectively; p=0.024).ConclusionThe data obtained from the present study suggest that higher levels of both serum fetuin-A and oxidative stress markers might be related with PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak

Uyanıkoğlu

Incebiyik

et al. 2018

Clin Exp Reprod Med

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“…Different results have been obtained by various studies conducted in 2 different regions of our country. While Tokmak et al 24 defined a significant correlation between AMH and insulin resistance (IR) among non-obese adolescents, Şahmay et al 25 reported no correlation between AMH and IR. Although there was a weak positive correlation between insulin level and AMH in our study, no correlation between IR, serum fasting glucose and AMH was detected.…”

Section: Discussionmentioning

confidence: 99%

Can we use serum Anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles

Aydoğmuş

Kelekçi

Elmalı

et al. 2018

SMJ

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Objectives:To compare Anti-Mullerian hormone (AMH) concentrations between polycystic ovary syndrome (PCOS) patients and healthy women who have polycystic ovarian morphology (PCOM) with regular menstrual cycles, and to determine a diagnostic cutoff value for PCOS women during reproductive period.Methods:This study was carried out between February 2013 and October 2017 at the Department of Obstetrics and Gynecology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey. Seventy PCOS patients and 70 PCOM women with normal menstrual cycles were included in the study. Blood samples of the subjects were obtained following an 8-hour fast for AMH and biochemical assessments, serum gonadotropin, and androgen measurements.Results:The mean serum AMH levels of PCOS patients were found to be higher than PCOM women with normal menstrual cycles (p<0.01). The optimal serum AMH cutoff value for PCOS diagnosis was determined as 3.51 ng/ml (sensitivity 72.8%, specificity 75.7%).Conclusion:Serum AMH concentrations are significantly higher in PCOS patients independent from the ovarian morphology and number of follicles per ovary. Positive and negative predictive values of AMH in PCOS diagnosis were found to be 75% and 73.6%, respectively, with a cutoff value of 3.51 ng/mL.

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“…Moreover, pancreatic β-cell dysfunction and Insulin Resistance (IR) are considered to be major biological aspects that lead to the development of type-2 diabetes. Hence, women suffering from PCOS were reported to have higher rates for type-2 diabetes in the long term [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Inter-relationship of circulating biochemical markers of oxidative stress and comorbid condition in polycystic ovary syndrome

Rasool¹,

Ahmad²,

Rizwan³

et al. 2018

biomedicalresearch

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Introduction: Polycystic Ovarian Syndrome (PCOS), commonly found in 5% of all women of reproductive age is a heterogeneous endocrine disorder in which woman's levels of estrogen and progesterone are imbalance leading to the growth of benign masses in the ovaries (ovarian cysts). Rotterdam criteria used to diagnose PCOS include two of three clinical features: 1) oligo-or anovulation, 2) hyperandroginism e.g., hirsutism, acne etc. and 3) sonographic morphologic evidence of polycystic ovaries. Aim: To investigate the relationship between circulating biomarkers and their heterogeneity in PCOS. Material and methods: A prospective case control study was conducted including 70 females of age ranging from 20 to 35 y out of which 20 served as healthy controls and 50 were patients of PCOS. Lipid levels, renal profile and antioxidative status of Malondialdehyde (MDA), Catalase (CAT), Superoxide dismutase (SOD) and Reduced glutathione (GSH) was analysed quantitatively. Serum electrolytes (Na + , K + , Mg 2+ , PO 4-3), anti-oxidants vitamins C and E and steroidal hormones like Follicle Stimulating Hormone (FSH), Sex Hormone Binding Globulin (SHBG) were measured by the commercially available kits. Results: A total of 70 patients were enrolled to the study. Serum electrolytes level like potassium (K) and Phosphorus (P) were significantly increased while antioxidants were decreased in the study group as compared to the control group. Oxidative stress was also increased with higher levels of MDA. Follicle Stimulating Hormone (FSH) and Sex Hormone Binding Globulin (SHBG) were decreased in the study group. The PCOS patients showed statistically significant correlation among the circulating biomarkers like FSH vs. prolactin (r=0.400 **).

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Association between anti-Mullerian hormone and insulin resistance in non-obese adolescent females with polycystic ovary syndrome

Abstract: We found that serum AMH levels were higher in non-obese adolescent females with PCOS and IR than in PCOS patients without IR and the healthy controls. There was a significant positive correlation between AMH levels and IR in non-obese adolescent females with PCOS.

Cited by 23 publications

References 35 publications

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Can we use serum Anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles

Inter-relationship of circulating biochemical markers of oxidative stress and comorbid condition in polycystic ovary syndrome

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