The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP–SNP Interaction in Chinese Women

Abstract

rs4646903 minor alleles and interaction between rs4646903 and rs1048943 were associated with increased cervical cancer risk.

Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women

“…Our results show a lack of significant association between m1 and m2 polymorphisms and cervical cancer risk, which as in several others tudies-done among Japanese, Israeli Jewish, Polish, Chinese, and Indian populations (Sugawara et al, 2003;Gutman et al, 2009;Roszak et al, 2014;Tan et al, 2016). To contrast, significant associations between m1 and/or m2 polymorphism and increased cervical cancer risk have been documented in several populations (Tan et al, 2017;Juárez-Cedillo et al, 2007;Jain et al, 2017;Li et al, 2016;Wang et al, 2017;Ding et al, 2018), and a meta-analysis indicated that the m1 (CC) genotype was associated with an increased risk for cervical cancer among Asians and Mixed populations (Wu et al, 2013). It is thus premature to conclude the role of m1 and m2 polymorphisms in cervical cancer development.…”

“…Ordinary, m1 and m3 are located in the 3' noncoding region, giving rise to a MspI restriction site; whereas m2 and m4 are located in exon 7, leading to the amino acid transition of isoleucine to valine on codon 462 and threonine to asparagine on codon 461, respectively (Li et al, 2004). To date, genetic polymorphisms of human CYP1A1 have been widely studied for the susceptibility to various cancers (e.g., cancer of lung, oral, larynx, breast, thyroid, prostate, renal, cervix uteri, gastric, and colon) (Li et al, 2004;Gajecka et al, 2005;Little et al, 2006;Siraj et al, 2008;Wright et al, 2010;Li et al, 2016;Balaji et al, 2012;Agudo et al, 2014;Meng et al, 2015). Notwithstanding, to our knowledge there are no recent reports of any association between the four polymorphic loci of the CYP1A1 and cervical cancer susceptibility (Sugawara et al, 2003;Juárez-Cedillo et al, 2007;Gutman et al, 2009;Roszak et al, 2014;Abbas et al, 2014;Tan et al, 2016;Jain et al, 2017).…”

CYP1A1 Ile462Val Polymorphism Is Associated with Cervical Cancer Risk in Caucasians Not Asians: A Meta-Analysis

“…The primary search yielded potentially related publications and finally 11 case-control studies involving 1,932 patients and 2,039 healthy controls were included (Sugawara et al, 2003 ; Huang et al, 2006 ; Joseph et al, 2006 ; Gutman et al, 2009 ; Zhang, 2009 , 2011 ; Ding et al, 2011 ; Shi et al, 2011 ; Abbas et al, 2014 ; Roszak et al, 2014 ; Li et al, 2016 ). Of these 11 case-control studies, four dealt with probands of Caucasian origin (Joseph et al, 2006 ; Gutman et al, 2009 ; Abbas et al, 2014 ; Roszak et al, 2014 ) and seven referred to Asian origin (Sugawara et al, 2003 ; Huang et al, 2006 ; Zhang, 2009 , 2011 ; Ding et al, 2011 ; Shi et al, 2011 ; Li et al, 2016 ); five studies were out of Hardy Weinberg Equilibrium (HWE) (Huang et al, 2006 ; Zhang, 2009 ; Ding et al, 2011 ; Shi et al, 2011 ; Abbas et al, 2014 ). Table 2 lists the main characteristics of identified studies.…”

“…However, two publications (Geng et al, 2010 ; Shi et al, 2011 ) involved the same subjects were both included in above meta-analysis. Moreover, several new original studies (Abbas et al, 2014 ; Roszak et al, 2014 ; Li et al, 2016 ) on this topic were published since then. The recent meta-analysis by Wang et al pooled the data of 8 case-control studies and indicated the CYP1A1 Ile462Val polymorphism might be a risk factor for cervical cancer (Wang et al, 2015 ).…”

Application of CRS‐PCR‐RFLP to identify CYP1A1 gene polymorphism

“…Li et al . studied the association between CYP1A1 gene polymorphism and cervical cancer risk in Chinese women and found that compared to subjects with AA of rs1048943 genotype, subjects with AG or GG of rs1048943 genotype have the highest cervical cancer risk.…”