Preparation of a partially carboxymethylated cotton gauze and study of its hemostatic properties

Chen, Jinghao; Lan, Guangqian; Li, Keying; Liu, Shibei; Yu, Kun; Liu, Jiawei; Tang, Hua; Dai, Fangyin; Deng-jun, WU

doi:10.1016/j.jmbbm.2016.04.018

Cited by 15 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Along the duration of the degradation time in vivo , the inflammatory response tends to be stable and alleviated due to the absorption of materials, indicating good biocompatibility. In this study, the degradation time in vivo of cellulose polymer materials was about 14 days, which shows an improved time compared to the ones reported in the literature [ 32 ]. This degradation time is moderate and poses no risk of foreign body residue and granuloma formation that would otherwise be seen in materials with a long degradation time [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 65%

“…For these reasons, the polysaccharide hemostatic material, a natural bioabsorbable polymer that has many desirable properties such as good biodegradability, good biocompatibility, and low cost, along with being abundantly available, is increasingly becoming a research hotspot of degradable hemostatic materials [26][27][28][29][30][31]. The most studied polysaccharide hemostatic materials include cellulose, chitosan, and starch [32,33]. Among them, cellulose could form a soft gel-like "pseudoclot" around the injury that acts as a barrier to occlude the blood flow while also can activate the intrinsic coagulation pathway to accelerate the blood coagulation process [34,35].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Biological Application of Novel Biodegradable Cellulose Composite as a Hemostatic Material

Zhu

Wang

et al. 2022

Mediators of Inflammation

View full text Add to dashboard Cite

Degradable hemostatic materials have unique advantages in reducing the amount of bleeding, shortening the surgical operation time, and improving patient prognosis. However, none of the current hemostatic materials are ideal and have disadvantages. Therefore, a novel biodegradable cellulose-based composite hemostatic material was prepared by crosslinking sodium carboxymethyl cellulose (CCNa) and hydroxyethyl cellulose (HEC), following an improved vacuum freeze-drying method. The resulting cellulose composite material was neutral in pH and spongy with a density of 0.042 g/cm3, a porosity of 77.68%, and an average pore size of 13.45 μm. The composite’s compressive and tensile strengths were 0.1 MPa and 15.2 MPa, respectively. Under in vitro conditions, the composites were degraded gradually through petite molecule stripping and dissolution, reaching 96.8% after 14 days and 100% degradation rate at 21 days. When implanted into rats, the degradation rate of the composite was slightly faster, reaching 99.7% in 14 days and 100% in 21 days. Histology showed a stable inflammatory response and no evidence of cell degeneration, necrosis, or abnormal hyperplasia in the tissues around the embedded material, indicating good biocompatibility. In the hemorrhagic liver model, the time to hemostasis and the total blood loss in the cellulose composite group was significantly lower than in the medical gauze group and the blank control group ( P < 0.05 ). These data indicate that the novel cellulose composite is a promising implantable hemostatic material in clinical settings.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Biological Application of Novel Biodegradable Cellulose Composite as a Hemostatic Material

Zhu

Wang

et al. 2022

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…In recent decades, many hemostatic agents were developed to achieve rapid hemostasis and reduce the death rate in prehospital period. 9–24 An ideal hemostatic agent should be safe, effective, easy to store and use, cheap and flexible to various types of wound site. Aluminum silicate materials were widely used for temporary hemostasis of external wounds both in military and civilian fields because of their low cost and high effectiveness, 19,25 and they are normally deemed to be nontoxic to humans.…”

Section: Introductionmentioning

confidence: 99%

Safety evaluation of a low-heat producing zeolite granular hemostatic dressing in a rabbit femoral artery hemorrhage model

Chen

Shang

et al. 2019

J Biomater Appl

View full text Add to dashboard Cite

Aluminum silicate materials were widely used for temporary hemostasis of external wounds. Although they are commonly deemed to be nontoxic, side effects were proved to have some potential risks. In addition to obvious thermal effect and distal thrombosis, other chemical analysis should be performed to validate whether there is active components in the blood circulation system even when there is no obvious distal thrombosis. On the other hand, blood electrolytes disturbance is a safety concern, and this issue has been ignored in previous studies. In this study, a systematic and stringent safety evaluation of aluminium silicate hemostatic agents was performed to provide useful information for their future clinical applications. In this study, a low-heat producing Zeolite Granular Dressing (Z-Granular, Zeo-Innov Medical Technology Co., Ltd, Hangzhou, China) was used as hemostatic agents for safety evaluation in a rabbit femoral artery hemorrhage model. In addition to the time to achieve definite hemostasis and heat producing properties, blood electrolytes concentrations of the rabbits pre- and post-application were measured. Although the in vitro electrolyte concentration tests indicated the significant change of Ca2+ and K+ after the zeolite-accelerated hemostasis, in vivo rabbit model suggested that no obvious blood electrolyte disordered occurred. X-ray photography confirmed that there is no zeolite residual granule remained in the wound sites after the debridement. Element analysis proved that the possibility of these inorganic materials entering the blood circulation is very low. The histological results revealed that no pathological changes resulting from Z-Granular were found. Thus, Zeolite Granular Dressing would be an effective and safe hemostatic agent for emergency arterial bleeding. Furthermore, packing zeolite granules within nonwoven-fabric bags would solve the problem of debridement without compromising their hemostatic efficiency. This is a systematic and stringent safety evaluation of aluminium silicate hemostatic agents and provides useful information for their future clinic applications.

show abstract

Biomedical Application of Cotton and Its Derivatives

Shahriari-Khalaji

Lugoloobi

2020

Textile Science and Clothing Technology

View full text Add to dashboard Cite

Preparation of a partially carboxymethylated cotton gauze and study of its hemostatic properties

Cited by 15 publications

References 16 publications

Biological Application of Novel Biodegradable Cellulose Composite as a Hemostatic Material

Biological Application of Novel Biodegradable Cellulose Composite as a Hemostatic Material

Safety evaluation of a low-heat producing zeolite granular hemostatic dressing in a rabbit femoral artery hemorrhage model

Biomedical Application of Cotton and Its Derivatives

Contact Info

Product

Resources

About