Efficacy and safety of Ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: A randomised controlled crossover trial

Lauche, Romy; Kumar, Syal; Hallmann, Julia; Lüdtke, Rainer; Rampp, Thomas; Dobos, Gustav; Langhorst, Jost

doi:10.1016/j.ctim.2016.04.002

Cited by 28 publications

(52 citation statements)

References 23 publications

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“…Adverse events. Six trials 18,13,14,28,40,43,59 had reported serious adverse events (AEs) but the relationships to most of the experimental drugs were assessed by the investigators as unlikely. HMs tended to have more patients with AEs than placebo (RR = 1.22, 95% CI 1.06-1.41, Fig.…”

Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

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Background and Aims The efficacy of herbal medicines (HMs) for functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional dyspepsia (FD) and functional constipation (FC) is controversial. A systematic review with meta‐analysis was conducted to determine their effectiveness for FGIDs. Methods We searched the following electronic databases till July 2019 with English language restriction: The Cochrane Library, EMBASE and PUBMED. Randomized double‐blind controlled trials of HMs compared with placebo or conventional pharmacological drugs for adult FGIDs patients were included. Results In total, 49 trials involving 7396 participants with FGIDs were included. The risk of bias was low in 9, unclear in 36, and high in 4 trials. More than 33 different herbal formulae were tested. HMs demonstrated statistically significant benefits for symptom improvement compared with placebo in 46 trials (RR = 1.67, 95% CI 1.48–1.88). When compared with conventional pharmacological therapy in 5 trials, HMs were found to be non‐inferior (RR = 1.10, 95% CI 1.03–1.18). The number of trials with regards to FD, IBS and FC were 19, 23 and 7 respectively. Subgroup analysis found that HMs were better than placebo in alleviating symptoms for FD (RR = 1.50, 95% CI 1.32–1.69), IBS (RR = 1.62, 95% CI 1.32–1.97) and FC (RR = 3.83, 95% CI 2.26–6.50). HMs tended to have more patients with adverse events than placebo, but similar to conventional pharmacological drugs. Conclusions Our findings provide a positive signal for HMs as a potentially well‐tolerated and effective treatment for FGIDs, deserving further examination in high‐quality trials.

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Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

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“…Also, on a human skin cells study, Aslam et al reported that P. granatum seed oil stimulates keratinocyte proliferation and induces a mild thickening of the epidermis without the loss of ordered differentiation 27. In complementary medicine, the effect of P. granatum extract in diabetes mellitus and irritable bowel syndrome was investigated 28,29…”

Section: Introductionmentioning

confidence: 99%

Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing <em>Punica granatum</em> seed oil and <em>Croton lechleri</em> resin extract

Bogdan¹,

Iurian

Tomuță

et al. 2017

DDDT

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Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatum seed oil and Croton lechleri resin extract) and demonstrate its positive effect on prevention and treatment of striae distensae. First, the cream base formulation was optimized through experimental design. Secondly, the cream containing the two active ingredients was investigated in an interventional nonrandomized clinical trial. The clinical outcome was assessed through biophysical parameters and ultrasonographic evaluation. The state of the skin was evaluated by biophysical measurements and ultrasonography at the beginning of the study and after 3 and 6 weeks. The experimental design was successfully used to set the best ranges for the technological and formulation factors to obtain a cosmetic formulation with optimal characteristics. The study of clinical efficacy on the optimal formulation revealed an increase in the dermis thickness, hydration and elasticity values in both groups after 6 weeks of cream application. The new oil-in-water cream containing P. granatum seed oil and C. lechleri resin extract can be helpful in the prevention or improving of skin changes associated with striae.

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“…Overall, random-effects meta-analysis based on three studies and 326 subjects found curcumin to have beneficial but not statistically significant effects on IBS symptoms. Of the five clinical trials reviewed, three reported positive and significant effects for curcumin-containing products [ 24 , 26 , 28 ], while two [ 25 , 27 ] found no significant effects compared to placebo and advised against monotherapy with curcumin. It is important to note that in the study by Brinkhaus et al [ 25 ], diagnosis of IBS was not based on the established Rome Criteria [ 29 ], but rather an intensive clinical examination ruling out other organic causes.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS)

Soh

Loke

et al. 2018

JCM

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Irritable bowel syndrome (IBS) remains a prevalent and difficult-to-manage gastrointestinal condition. There is growing interest in the use of traditional medicine to manage IBS. In particular, curcumin, a biologically active phytochemical, has demonstrated anti-inflammatory and anti-oxidant properties and mucosal protective effects in rat models of colitis. This meta-analysis thus aimed to investigate the hypothesis that curcumin improves IBS symptoms. Using the keywords (curcumin OR turmeric OR Indian saffron OR diferuloylmethane OR curcuminoid) AND (irritable bowel syndrome OR IBS), a preliminary search on the PubMed, Medline, Embase, PsychINFO, Web of Science, and Google Scholar databases yielded 1080 papers published in English between 1 January 1988 and 1 May 2018. Five randomized, controlled trials were systematically reviewed and 3 were included in the final meta-analysis. Random-effects meta-analysis based on three studies and 326 patients found curcumin to have a beneficial albeit not statistically significant effect on IBS symptoms (pooled standardized mean difference from baseline IBS severity rating −0.466, 95% CI: −1.113 to 0.182, p = 0.158). This is the first meta-analysis to examine the use of curcumin in IBS. With its unique anti-oxidant and anti-inflammatory activities and ability to modulate gut microbiota, curcumin is a potentially useful addition to our armamentarium of agents for IBS. It also appears safe and well-tolerated, with no adverse events reported in the available trials. However, current findings are based on a considerably limited evidence base with marked heterogeneity. More robust clinical trials involving a standardized curcumin preparation and larger sample sizes should be encouraged.

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Efficacy and safety of Ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: A randomised controlled crossover trial

Cited by 28 publications

References 23 publications

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing <em>Punica granatum</em> seed oil and <em>Croton lechleri</em> resin extract

A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS)

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