Irritable Bowel Syndrome and Female Patients

Harris, Lucinda A.; Umar, Sarah B.; Baffy, Noemi; Heitkemper, Margaret

doi:10.1016/j.gtc.2016.02.001

Cited by 9 publications

(12 citation statements)

References 127 publications

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“…94,95 Because of gender differences in the prevalence and pathophysiology of IBS, an individualized and multicomponent approach considering sex and gender issue is necessary for treatment. 39,96…”

Section: Treatmentmentioning

confidence: 99%

Sex-Gender Differences in Irritable Bowel Syndrome

Kim

2018

J Neurogastroenterol Motil

214

133

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Because of the sex-gender differences that are shown in a diversity of physiological and psychological factors, it can be speculated that the clinical presentation of symptoms as well as treatment strategies in women and men with irritable bowel syndrome (IBS) may differ. Studies have revealed that IBS is more common in women than men. As for the IBS subtype, IBS with constipation is significantly more prevalent among women than men. Sex hormones and gender differences may play important roles in the pathophysiology of IBS. However, its pathophysiologic mechanisms still remain largely unknown, and therapeutic implications are limited. Moreover, women IBS patients have been reported to feel more fatigue, depression, anxiety, and lower quality of life than men IBS patients. Furthermore, there has been evidence of differences in the appropriate treatment efficacy to IBS in men and women, although relatively few men are enrolled in most relevant clinical trials. A more sex-gender-oriented approach in the medical care setting could improve understanding of heterogeneous patients suffering from IBS. An individualized and multicomponent approach including sex and gender issues might help improve the treatment of IBS.

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Section: Treatmentmentioning

confidence: 99%

Sex-Gender Differences in Irritable Bowel Syndrome

Kim

2018

J Neurogastroenterol Motil

214

133

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“…This higher incidence of symptoms in female individuals is not an isolated occurrence. Other functional gastrointestinal disorders, such as IBS, chronic functional constipation, and functional dyspepsia, have been shown to occur more frequently in female individuals . It is possible that women show high sensory dysfunction that affects the visceral territory, as their somatic sensibility is normal or may show an increased tolerance .…”

Section: Discussionmentioning

confidence: 99%

“…Other functional gastrointestinal disorders, such as IBS, chronic functional constipation, and functional dyspepsia, have been shown to occur more frequently in female individuals. 20,21 It is possible that women show high sensory dysfunction that affects the visceral territory, as their somatic sensibility is normal or may show an increased tolerance. 22 It should be noted that the percentage of symptomatic participants was lower in the glutenoverload phase than in the basal phase (38% vs 46%), although the percentage was higher in these phases than with the GFD (24%).…”

Section: Discussionmentioning

confidence: 99%

Coeliac disease and gastrointestinal symptom screening in adult first‐degree relatives

Vaquero

Rodríguez-Martín

Álvarez-Cuenllas

et al. 2017

J of Gastro and Hepatol

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“…IBS is a diverse disorder, and many factors have been implicated in its pathogenesis (Table 2) [18]. Not all factors may be present in one individual, but genetic, central (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…gut-brain dysregulation), hormonal, psychological, diet, and gastrointestinal (GI; e.g. altered motility) factors have all been proposed to be potential candidates [18][19][20][21]. Further, it is likely that IBS is a result of various interactions between genetic and environmental factors [22].…”

Section: Introductionmentioning

confidence: 99%

Modulation of the gut microbiota: a focus on treatments for irritable bowel syndrome

Harris

Baffy

2017

Postgraduate Medicine

Self Cite

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Irritable bowel syndrome (IBS), which is characterized by recurrent abdominal pain and disordered bowel habits, is one of the most common functional bowel disorders. IBS is a substantial burden on both patient health-related quality of life and healthcare costs. Several pathophysiologic mechanisms have been postulated for the occurrence of IBS, including altered gastrointestinal motility, visceral hypersensitivity, changes in gut permeability, immune activation, gut-brain dysregulation, central nervous system dysfunction, and changes in the gut microbiota. Of note, both qualitative and quantitative differences have been observed in the gut microbiota of a population with IBS versus a healthy population. Because of the substantial interest in the gut microbiota and its role as a therapeutic target in IBS, this article provides an overview of specific interventions with the potential to modulate the gut microbiota in IBS, including elimination diets, prebiotics, probiotics, synbiotics, and nonsystemic antibiotics. Although probiotics and synbiotics are generally well tolerated, differences in the composition and concentration of different bacterial species and inclusion or exclusion of prebiotic components varies widely across studies and has prevented strong recommendations on their use in IBS. For nonsystemic antibiotics, rifaximin is indicated in the United States for the treatment of IBS with diarrhea in adults and has been shown to be efficacious and well tolerated in well-designed clinical trials. Overall, more consistent evidence is needed regarding the efficacy and safety of elimination diets, prebiotics, probiotics, and synbiotics for the treatment of patients with IBS. Furthermore, additional well-designed studies are needed that examine alterations in the gut microbiota that occur with these interventions and their potential associations with clinical symptoms of IBS. ARTICLE HISTORY

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Irritable Bowel Syndrome and Female Patients

Cited by 9 publications

References 127 publications

Sex-Gender Differences in Irritable Bowel Syndrome

Sex-Gender Differences in Irritable Bowel Syndrome

Coeliac disease and gastrointestinal symptom screening in adult first‐degree relatives

Modulation of the gut microbiota: a focus on treatments for irritable bowel syndrome

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