Associations of Body Mass Index and Physical Activity With Sexual Dysfunction in Breast Cancer Survivors

Paiva, Carlos Eduardo; Rezende, Fabiana Faria; Paiva, Bianca Sakamoto Ribeiro; Mauad, Edmundo Carvalho; Zucca-Matthes, Gustavo; Carneseca, Estela Cristina; Syrjänen, Karí; Schover, Leslie R.

doi:10.1007/s10508-016-0758-7

Cited by 18 publications

(11 citation statements)

References 60 publications

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“…Results from a pilot study randomizing BCSs with menopausal symptoms to a lifestyle program including physical activity or standard care support this statement, demonstrating clinically significant reduction in both menopausal symptoms and sexual dysfunction in the intervention group [52]. Another study, exploring the associations of BMI, physical activity, and sexual dysfunction in BCSs, found that regular physical activity was associated with better sexual desire [53]. Further, physical activity may alleviate symptoms of depression [54], fatigue [55], and sleep problems [56], with the potential of indirectly improving sexual functioning.…”

Section: Discussionmentioning

confidence: 91%

Sexual activity and functioning in long-term breast cancer survivors; exploring associated factors in a nationwide survey

Smedsland

Vandraas

Bøhn

et al. 2022

Breast Cancer Res Treat

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Purpose Sexual health is a key quality of life issue. Knowledge concerning sexual health in long-term breast cancer survivors (BCSs) is limited. Within a nationwide sample, we aimed to assess the prevalence of sexual inactivity and to explore factors associated with sexual inactivity and reduced sexual functioning among long-term BCSs. Methods Long-term BCSs aged 20–65 years when diagnosed with early-stage breast cancer in 2011–2012 were identified by the Cancer Registry of Norway in 2019 (n = 2803) and invited to participate in a nationwide survey. Sexual health was measured using the multidimensional Sexual Activity Questionnaire. Factors associated with sexual inactivity and reduced sexual functioning were explored using multivariable logistic- and linear regression analyses with adjustments for relevant sociodemographic, health-, and cancer-related variables. Results The final sample consisted of 1307 BCSs with a mean age of 52 years at diagnosis. Fifty-two percent of the BCSs were sexually inactive. Lack of interest was the most common reason for sexual inactivity. Treatment with aromatase inhibitor (OR 1.73, 95% CI 1.23, 2.43) and poor body image (OR 0.99, 95% CI 0.99, 0.995) were associated with sexual inactivity. Among sexually active BCSs, depression (B − 1.04, 95% CI − 2.10, − 0.02) and physical inactivity (B − 0.61, 95% CI − 1.21, − 0.02) were inversely related to sexual pleasure. Treatment with aromatase inhibitor (B 0.61, 95% CI 0.20, 1.01), sleep problems (B 0.37, 95% CI 0.04, 0.70), breast symptoms (B 0.01, 95% CI 0.003, 0.02), and chronic fatigue (B 0.43, 95% CI 0.05, 0.81) were associated with sexual discomfort. Chemotherapy (OR 1.91, 95% CI 1.23, 2.97), current endocrine treatment (OR 1.98, 95% CI 1.21, 3.25), and poor body image (OR 0.98, 95% CI 0.98, 0.99) were associated with less sexual activity at present compared to before breast cancer. Conclusion Treatment with aromatase inhibitor seems to affect sexual health even beyond discontinuation. Several common late effects were associated with sexual inactivity and reduced sexual functioning. To identify BCSs at risk of sexual dysfunction, special attention should be paid to patients treated with aromatase inhibitor or suffering from these late effects.

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Section: Discussionmentioning

confidence: 91%

Sexual activity and functioning in long-term breast cancer survivors; exploring associated factors in a nationwide survey

Smedsland

Vandraas

Bøhn

et al. 2022

Breast Cancer Res Treat

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“…Several studies have evaluated the prevalence of SD among BCSs [14][15][16][17][18][19][20][21][22][23][24], but inconsistency in the definition and assessment of SD complicates interpretation and comparison of results.…”

Section: Introductionmentioning

confidence: 99%

“…However, FSFI does not account for distress and only few studies evaluating SD among BCSs have used an additional scale to integrate distress in their definition of SD [15,17,20,31]. Hence, prevalence estimates of SD among BCSs assessed by the FSFI show a considerable variation between studies, ranging from 32% to 93% [14][15][16][17][18][19][20][21]32]. These variations may also reflect differences in age and degree of sexual activity between cohorts.…”

Section: Introductionmentioning

confidence: 99%

The majority of Danish breast cancer survivors on adjuvant endocrine therapy have clinically relevant sexual dysfunction: a cross-sectional study

et al. 2020

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Background: Impairments in sexual function are common among breast cancer survivors (BCSs), particularly in BCSs receiving adjuvant endocrine therapy (AET). Whether these impairments cause distress, thus qualifying for a more clinically relevant diagnosis of sexual dysfunction (SD), is inadequately described among BCSs and represents an important research gap. Hence, the primary aim of this study was to estimate the prevalence of clinically relevant SD, in this context: impairments with associated distress, and to identify factors associated with SD among BCSs on AET. Secondly, to explore the extent of distress caused by specific impairments in sexual function. Materials and methods: In this cross-sectional study of BCSs on adjuvant treatment with endocrine therapy for at least three months, participants completed an online survey comprising standardized measures of sexual and psychosocial function. Female Sexual Function Index (FSFI) and Sexual Complaint Screener -Women (SCS-W) were used to asses clinically relevant SD. Multiple regression analyses were performed to identify factors significantly associated with SD. Results: In total, 333 BCSs with a mean age of 58.7 years were included in the study, of whom 227 were sexually active. Among sexually active BCSs, 134 (59%) met the criteria for having clinically relevant SD, of whom 78 (58%) perceived cancer treatment as the primary reason for their sexual problems. Factors associated with SD included vaginal dryness (adjusted OR¼ 2.25, 95% CI: 1.52-3.34, p < .01) and psychological well-being (adjusted OR¼ 1.11, 95% CI: 1.03-1.18, p < .01). Age was not related to neither prevalence of SD nor the level of distress caused by any impairment, with exception of low sexual desire. Pain in relation to intercourse was the most distressing impairment. Conclusion: SD was highly prevalent among sexually active BCSs on AET. Sexual health is important to address independent of the woman's age.

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“…Paiva et al showed the negative correlation between BMI and sexual function. [25] However, in a recent study, it is mentioned that there is no statistically significant correlation between FSFI scores and BMI. [26] In the present study, the BMI of BCS and MRM patients were similar.…”

Section: Discussionmentioning

confidence: 94%

A Comparison between Breast-Conserving Surgery and Modified Radical Mastectomy Concerning the Female Sexual Function in Breast Cancer Patients under 50 Years of Age

Bakkal¹

2020

TJ Oncol

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This study aims to compare the female sexual function in breast cancer patients, who have been administered breast-conserving surgery to the patients having undergone modified radical mastectomy. METHODS Forty-four breast-conserving surgery and 27 modified radical mastectomy patients were included in this study. All patients completed chemotherapy and radiation therapy after surgery. Modified radical mastectomy patients, who received breast reconstruction surgery afterwards, patients whom experienced local recurrence or distant organ metastases or patients over 50 years of age were excluded from this study. Each patient's sexual function was evaluated using the Female Sexual Function Index, six months after the completion of their treatment. RESULTS Between breast-conserving surgery and modified radical mastectomy groups, no significant difference of age, height, weight, and body mass index was observed. Although mean sexual desire (4,13 vs 3,97), arousal (3,72 vs 3,16), lubrication (3,76 vs 3,44), orgasm (3,90 vs 3,38), satisfaction (3,07 vs 2,50), pain (4,07 vs 3,82) and total scores (22,65 vs 20,27) were all higher in patients with breast-conserving surgery, only arousal, orgasm and total scores were significantly higher (p: 0,025, p:0,017 and p: 0,017, respectively). CONCLUSION In the treatment of breast cancer, the conservation of patients' sexual function is an important issue. Our study demonstrates higher female sexual function in breast-conserving surgery patients, highlighting the statistical difference of the arousal, orgasm and total scores of the Female Sexual Function Index, comparing with modified radical mastectomy patients.

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Associations of Body Mass Index and Physical Activity With Sexual Dysfunction in Breast Cancer Survivors

Cited by 18 publications

References 60 publications

Sexual activity and functioning in long-term breast cancer survivors; exploring associated factors in a nationwide survey

Sexual activity and functioning in long-term breast cancer survivors; exploring associated factors in a nationwide survey

The majority of Danish breast cancer survivors on adjuvant endocrine therapy have clinically relevant sexual dysfunction: a cross-sectional study

A Comparison between Breast-Conserving Surgery and Modified Radical Mastectomy Concerning the Female Sexual Function in Breast Cancer Patients under 50 Years of Age

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