Predictors of coronary artery disease in middle‐aged Taiwanese women at premenopause, postmenopause and after undergoing hysterectomy

Tsai, Ching Ching; Hsieh, Ming Hsiung; Yang, Hao; Chan, Paul; Jeng, Chii

doi:10.1111/jocn.13258

Cited by 1 publication

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“…Because OP may progress without symptoms and is associated with age-related fractures, it is now recognized as a major threat, and Taiwan policymaking to address the prevalence of OP reached a critical point in 2005 [ 9 ]. According to the Taiwan Ministry of Health and Welfare in 2015, the prevalence of OP was 17.4% in 2001 and 25% in 2011 [ 9 ], and CAD ranked the second highest cause of death among women in Taiwan [ 10 ]. Both diseases can independently progress to more severe conditions, which will result in a large socioeconomic burden [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The association between coronary artery disease and osteoporosis: a population-based longitudinal study in Taiwan

et al. 2022

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Purpose This large population-based study is the first to analyze the association between coronary artery disease (CAD) and osteoporosis (OP) from the National Health Insurance Research Database (NHIRD) in Taiwan to determine if CAD is associated with OP. Methods Data from NHIRD, a national, population-based, retrospective, matched cohort study of 23 million patients, were collected to recruit two matched cohorts: with (n = 192,367) and without (n = 192,367) CAD. The Cox model was used to compare the incidence rate ratio and crude hazard ratio (HR) between the two cohorts for osteoporotic fracture and OP. Results The CAD cohort had a significantly increased risk for vertebral compression fracture, with an adjusted HR of 1.74 (95% CI, 1.60–1.89). The cumulative incidence of OP was also statistically higher in the cohort versus without CAD (11.6% vs. 5.6%; p ≤ 0.0001, log-rank) during the 10-year follow-up period. The Cox model showed a 2.04-fold increase in the incidence of OP in the CAD cohort, with an adjusted HR of 2.04 (95% confidence interval [CI], 1.99–2.08). Conclusions A positive association exists between CAD and development of subsequent osteoporotic fracture and OP. Patients with CAD have a significantly increased risk of developing vertebral compression fracture and a higher incident rate ratio of OP. Trial registration IRB approval number: No. C108094 on February 19, 2020.

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