Effect of Parachlamydia acanthamoebae on pulmonary function parameters in a bovine respiratory model

Lohr, Markus; Prohl, Annette; Ostermann, Carola; Diller, Roland; Greub, Gilbert; Reinhold, Petra

doi:10.1016/j.tvjl.2016.04.003

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…such as C . psittaci (Lohr et al, 2015, 2016). However, although the prevalence of these organisms seems to suggest endemicity or in the absence of clinical disease potentially a commensal role, the source of infection has largely remained conjecture.…”

Section: Discussionmentioning

confidence: 99%

“…Although this has suggested a hitherto unrecognised cause of livestock disease the absence of marked pathophysiology after experimental respiratory infection in cattle with Parachlamydia implies that the organisms exhibit lower levels of pathogenicity than Chlamydia sp. such as C. psittaci (Lohr et al, 2015(Lohr et al, , 2016. However, although the prevalence of these organisms seems to suggest endemicity or in the absence of clinical disease potentially a commensal role, the source of infection has largely remained conjecture.…”

Section: Discussionmentioning

confidence: 99%

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Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle

Wheelhouse

Hearn

Livingstone

et al. 2022

Journal of Applied Microbiology

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Aims:The order Chlamydiales comprises a broad range of bacterial pathogens and endosymbionts, which infect a wide variety of host species. Within this order, members of the family Parachlamydiaceae, which includes Parachlamydia and Neochlamydia species, have been particularly associated with infections in both humans and cattle, including having a potential pathogenic role in cases of bovine abortion. While the route of transmission has yet to be defined, it has been hypothesised that asymptomatic carriage and contamination of the immediate environment may be a route of inter-animal transmission. We investigated the asymptomatic carriage of Chlamydia-related organisms in healthy cattle. Methods& Results: DNA was isolated from nasal and rectal swabs obtained from 38 healthy dairy heifers. A Chlamydiales sp. 16S rRNA qPCR was performed on each sample. A total of 18/38 nasal samples and all 38/38 rectal samples were identified as positive for Chlamydiales sp. Each positive sample was sequenced confirming the presence of DNA belonging to the Parachlamydiaceae. Conclusions:The presence of Parachlamydiaceae DNA in nasal and rectal swab samples of healthy cattle provides evidence for the asymptomatic carriage of parachlamydial organisms within cattle. Significance & Impact of the Study:The study provides evidence of potential routes of environmental contamination that could provide a route for inter-animal and animal transmission of Parachlamydiaceae.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle

Wheelhouse

Hearn

Livingstone

et al. 2022

Journal of Applied Microbiology

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“…That Vt is a parameter worth measuring in calves has been proven in studies to quantify respiratory symptoms [ 18 , 19 ] or to assess the effects of therapies [ 20 ]. It is a well-known phenomenon that calves suffering from pneumonia show significantly lower Vt and higher RR than healthy calves [ 21 , 22 ]. Since Vt is inevitably associated with RR, a higher RR usually compensates for a lower Vt to avoid hypoventilation and to maintain the supply of oxygen to the organism [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Since the IOS was originally developed for human medicine, it has been applicable to calves with body weights comparable to those of adult humans. Under experimental conditions, IOS has been proven to measure RR and Vt in calves with high accuracy [ 21 , 22 ] (and can therefore be regarded as the gold standard method. The aim of this study was to evaluate whether the previously developed RR sensor could be expanded to measure Vt as well.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Respiration Rate Sensor for Recording Tidal Volume in Calves under Field Conditions

Dißmann

Reinhold

Smith³

et al. 2023

Sensors

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In the assessment of pulmonary function in health and disease, both respiration rate (RR) and tidal volume (Vt) are fundamental parameters of spontaneous breathing. The aim of this study was to evaluate whether an RR sensor, which was previously developed for cattle, is suitable for additional measurements of Vt in calves. This new method would offer the opportunity to measure Vt continuously in freely moving animals. To measure Vt noninvasively, the application of a Lilly-type pneumotachograph implanted in the impulse oscillometry system (IOS) was used as the gold standard method. For this purpose, we applied both measuring devices in different orders successively, for 2 days on 10 healthy calves. However, the Vt equivalent (RR sensor) could not be converted into a true volume in mL or L. For a reliable recording of the Vt equivalent, a technical revision of the RR sensor excluding artifacts is required. In conclusion, converting the pressure signal of the RR sensor into a flow equivalent, and subsequently into a volume equivalent, by a comprehensive analysis, provides the basis for further improvement of the measuring system.

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Bovine Respiratory Disease

Kaske,

Reinhold,

Pardon

et al. 2024

Production Diseases in Farm Animals

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Effect of Parachlamydia acanthamoebae on pulmonary function parameters in a bovine respiratory model

Cited by 3 publications

References 26 publications

Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle

Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle

Evaluation of a Respiration Rate Sensor for Recording Tidal Volume in Calves under Field Conditions

Bovine Respiratory Disease

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