Preparation and properties of novel hydrogel based on chitosan modified by poly(amidoamine) dendrimer

He, Guowei; Zhu, Chao; Ye, Shengyang; Cai, Weiquan; Yin, Yi; Zheng, Huaili

doi:10.1016/j.ijbiomac.2016.05.091

Cited by 24 publications

(6 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The thermal stability of PP/PAMAM composition rises with increasing PAMAM content in the composites. 41 The DTG data from Figure 5 and Table 2 show reveal that the overall thermal stability of the prepared composites is 100°C starting at decomposition peak temperature ( T d ) 280°C up to decomposition peak temperature 380°C. It can be assumed that the existence of PAMAM improves the thermal stability of the PP/PAMAM composites.…”

Section: Resultsmentioning

confidence: 98%

Polypropylene based bio-composites for packaging materials: Physico-mechanical impacts of prepared hyper-branched polyamidoamine and gamma-irradiation

Fathy

Ibrahim

Elnaggar

et al. 2023

Journal of Thermoplastic Composite Materials

View full text Add to dashboard Cite

In an attempt to produce bio-composites that possess good physico-mechanical properties, polyamidoamine (PAMAM) was synthesized and characterized as a multi-nitrogen terminal biocompatible and nontoxic polymeric species. It was mixed at various ratios of 1.0, 2.0, and 3.0% with polypropylene (PP) via Brabender-like apparatus. The prepared bio-composites were exposed to 20 kGy of gamma-irradiation to investigate the influence of ionizing radiation on the fabricated specimens. Parameters of mechanical for instance tensile strength (TS), modulus of elasticity (EM), elongation at break (%), and hardness (Shore D), of bio-composites, were considered. Moreover, the stress-strain curves of the fabricated samples were investigated. Furthermore, FTIR and thermal analysis including TGA and DSC have been investigated. The crystallinity % of all investigated samples was calculated on the basis of DSC measurements. Overall migration of prepared samples has been performed as an applicable study of food packaging. FTIR results revealed the disappearance of the absorption peak at 1730 cm−l of the carbonyl group of polyamidoamine after the formation of PP/PAMAM bio-composites, indicating a successful combination of the PP matrix with polyamidoamine. The incorporation of PAMAM resulted in a steady improvement of the melting temperature (Tm) of the native PP. The thermal stability of PP/PAMAM composition increases with increasing PAMAM and after being exposed to 20 kGy irradiation. Mechanical data revealed that TS of PP increased with PAMAM content up to 3.0%. The development in TS increased from 20 MPa of native PP to 45 MPa of PP/2% PAMAM bio-composites suggesting the superior interaction between the synthetic PAMAM and PP texture. Furthermore, the prepared bio-composite films displayed highly acceptable migration limits.

show abstract

Section: Resultsmentioning

confidence: 98%

Polypropylene based bio-composites for packaging materials: Physico-mechanical impacts of prepared hyper-branched polyamidoamine and gamma-irradiation

Fathy

Ibrahim

Elnaggar

et al. 2023

Journal of Thermoplastic Composite Materials

View full text Add to dashboard Cite

show abstract

“…This was due to the change of group >CH-CH2-OC(O)O- (peak i) to group >CH-CH2-OC(O)NH- (peak i’). These signals demonstrate that PEG was conjugated with G3.0 [ 32 , 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Retrovirus Drugs-Loaded PEGylated PAMAM for Prolonging Drug Release and Enhancing Efficiency in HIV Treatment

Nguyen

et al. 2021

Polymers

View full text Add to dashboard Cite

Polyamidoamine dendrimer (PAMAM) with its unique characteristics emerges as a potential drug delivery system which can prolong releasing time, reduce the side effects but still retaining treatment efficiency. In this study, methoxy polyethylene glycol modified PAMAM generation 3.0 (G3.0@mPEG) is prepared and characterized via 1H-NMR, FT-IR, and TEM. Subsequently, two antiretroviral agents (ARV) including lamivudine (3TC) and zidovudine (AZT) are individually encapsulated into G3.0@mPEG. The drug-loading efficiency, drug release profile, cytotoxicity and anti-HIV activity are then evaluated. The results illustrate that G3.0@mPEG particles are spherical with a size of 34.5 ± 0.2 nm and a drug loading content of about 9%. Both G3.0@mPEG and ARV@G3.0@mPEG show no cytotoxicity on BJ cells, and G3.0@mPEG loading 3TC and AZT performs sustained drug release behavior which is best fitted with the Korsmeyer–Peppas model. Finally, the anti-HIV activity of ARV via Enzymatic Assay of Pepsin is retained after being loaded into the G3.0@mPEG, in which about 36% of pepsin activity was inhibited by AZT at the concentration of 0.226 mM. Overall, PAMAM G3.0@mPEG is a promising nanocarrier system for loading ARV in HIV treatment and prevention.

show abstract

“…Further, the antimicrobial results showed that the hydrogels exhibited better antimicrobial activity against both Staphylococcus aureus and Escherichia coli as the PAMAM content, the As a kind of natural cationic polysaccharide, chitosan has good biosafety and biodegradability. Due to the presence of protonated amino groups in its molecular chain, chitosan exhibits certain antibacterial and antioxidant properties [82][83][84]. In addition, the reactive amino groups in chitosan's units can participate in grafting, crosslinking, and polymerization reactions; therefore, chitosan is often used in the preparation of multifunctional biomaterials [85,86].…”

Section: Bacterial Infection Treatmentmentioning

confidence: 99%

Recent Research Progress on Polyamidoamine-Engineered Hydrogels for Biomedical Applications

Liu,

Li,

Yang

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Hydrogels are three-dimensional crosslinked functional materials with water-absorbing and swelling properties. Many hydrogels can store a variety of small functional molecules to structurally and functionally mimic the natural extracellular matrix; hence, they have been extensively studied for biomedical applications. Polyamidoamine (PAMAM) dendrimers have an ethylenediamine core and a large number of peripheral amino groups, which can be used to engineer various polymer hydrogels. In this review, an update on the progress of using PAMAM dendrimers for multifunctional hydrogel design was given. The synthesis of these hydrogels, which includes click chemistry reactions, aza-Michael addition, Schiff base reactions, amidation reactions, enzymatic reactions, and radical polymerization, together with research progress in terms of their application in the fields of drug delivery, tissue engineering, drug-free tumor therapy, and other related fields, was discussed in detail. Furthermore, the biomedical applications of PAMAM-engineered nano-hydrogels, which combine the advantages of dendrimers, hydrogels, and nanoparticles, were also summarized. This review will help researchers to design and develop more functional hydrogel materials based on PAMAM dendrimers.

show abstract

Preparation and properties of novel hydrogel based on chitosan modified by poly(amidoamine) dendrimer

Cited by 24 publications

References 55 publications

Polypropylene based bio-composites for packaging materials: Physico-mechanical impacts of prepared hyper-branched polyamidoamine and gamma-irradiation

Polypropylene based bio-composites for packaging materials: Physico-mechanical impacts of prepared hyper-branched polyamidoamine and gamma-irradiation

Retrovirus Drugs-Loaded PEGylated PAMAM for Prolonging Drug Release and Enhancing Efficiency in HIV Treatment

Recent Research Progress on Polyamidoamine-Engineered Hydrogels for Biomedical Applications

Contact Info

Product

Resources

About