Characteristics of 419 patients with acquired middle ear cholesteatoma

Abstract

The prevalence of cholesteatoma in patients with chronic otitis media was 24.5% and it was more common in adults than in children. Posterior mesotympanic cholesteatoma was more frequent, with no difference in mean air-bone gap between the different routes of formation. In patients undergoing surgery, open tympanomastoidectomy was the procedure most frequently chosen.

Detection of respiratory viruses in primary cholesteatoma tissues

“…An important contributing factor for auditory tubal dysfunction is the mechanical obstruction caused by adenotonsillar hypertrophy, which can deregulate the pressure in the middle ear cavity 19 . This was supported by a prospective cohort study of 1710 patients with chronic otitis media, which revealed that nearly 25% developed cholesteatomas 7 . The improvement of otitis media with effusion (OME) post adenoidectomy in children suggests that adenoids may act as reservoirs of microbial infections 20‐23 .…”

“…19 This was supported by a prospective cohort study of 1710 patients with chronic otitis media, which revealed that nearly 25% developed cholesteatomas. 7 The improvement of otitis media with effusion (OME) post adenoidectomy in children suggests that adenoids may act as reservoirs of microbial infections. [20][21][22][23] In studies of colonization of adenotonsillar tissues by bacteria and viruses, multiple pathogens were detected.…”

“…The pathogenesis of primary acquired cholesteatoma is not fully understood and several lines of evidence suggest that it is multifactorial 5,6 . There is evidence that otitis media and associated dysfunction of the auditory tube may play an important role in the development of primary acquired cholesteatoma 7 . In a previous study we showed that several viruses were detectable in middle ear secretions from children with otitis media with effusion (OME), suggesting that the middle ear effusion could be a reservoir of persisiting viral infections 8 .…”

Uniform Registration Agreements on Cholesteatoma Care: A Nationwide Consensus Procedure

“…However, the use of a questionnaire or the systematic questioning of patients regarding their symptoms does not yet appear to be general practice. The national cholesteatoma study and the literature ( 16 , 17 ) show that hearing loss with or without otorrhea is the most important health concern. In addition, to improve hearing, the cessation of otorrhea is a determining factor for the success of surgery according to patients.…”

“…To obtain a better understanding of outcome measures that are important for patients, a list of the most frequently reported symptoms (both pre- and postoperative) was drawn up from the literature ( 16 – 19 ). This information was combined with the information on overall patients’ symptoms taken from the national Dutch Cholesteatoma Data study (DCD) (trial 80-83700-98-16504).…”