Can Kidney Transplantation Improve Arterial Stiffness in End-Stage Renal Patients?

Ro, Han; Kim, A.J.; Chang, Jae Hyun; Jung, Ji Yong; Chung, Wookyung; Park, Y.H.; Lee, H.H.

doi:10.1016/j.transproceed.2015.12.080

Cited by 13 publications

(10 citation statements)

References 15 publications

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“…All studies were quasiexperimental with before‐after design study and published in English between 2003 and 2016. Seven studies assessed aortic PWV (central), 3 studies assessed peripheral PWV (carotid‐radial or femoral‐distal PWV), and 4 studies assessed brachial‐ankle PWV. Two studies assessed both central and peripheral PWV, and 3 studies used multiple periods of assessment.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies assessed aortic PWV (central), 3 studies assessed peripheral PWV (carotid‐radial or femoral‐distal PWV), and 4 studies assessed brachial‐ankle PWV. Two studies assessed both central and peripheral PWV, and 3 studies used multiple periods of assessment. Central PP was reported in 4 studies and AIx in 7 studies .…”

Section: Resultsmentioning

confidence: 99%

“…Three studies evaluated medium‐sized muscular vascular beds, which are physiologically stiffer and generally less affected by age and pathological conditions . Finally, 4 studies looked at brachial‐ankle PWV, which gives a general index of overall stiffness. Three studies performed measurement at different periods post‐KTx, and 2 studies used multiple sites.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, 4 studies looked at brachial‐ankle PWV, which gives a general index of overall stiffness. Three studies performed measurement at different periods post‐KTx, and 2 studies used multiple sites.…”

Section: Discussionmentioning

confidence: 99%

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Reduction of Arterial Stiffness After Kidney Transplantation: A Systematic Review and Meta‐Analysis

Sidibé

Fortier

Desjardins

et al. 2017

JAHA

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BackgroundEnd‐stage kidney disease is associated with increased arterial stiffness. Although correction of uremia by kidney transplantation (KTx) could improve arterial stiffness, results from clinical studies are unclear partly due to small sample sizes.Method and ResultsWe conducted a systematic review and meta‐analysis of before‐after design studies performed in adult KTx patients with available measures of arterial stiffness parameters (pulse wave velocity [PWV], central pulse pressure [PP], and augmentation index) before and at any time post‐KTx. Mean difference of post‐ and pre‐KTx values of different outcomes were estimated using a random effect model with 95% confidence interval. To deal with repetition of measurement within a study, only 1 period of measurement was considered per study by analysis. Twelve studies were included in meta‐analysis, where a significant decrease of overall PWV by 1.20 m/s (95% CI 0.67‐1.73, I2=72%), central PWV by 1.20 m/s (95% CI 0.16‐2.25, I2=83%), peripheral PWV by 1.17 m/s (95% CI 0.17‐2.17, I2=79%), and brachial‐ankle PWV by 1.21 m/s (95% CI 0.66‐1.75, I2=0%) was observed. Central PP (reported in 4 studies) decreased by 4.75 mm Hg (95% CI 0.78–10.28, I2=50%). Augmentation index (reported in 7 studies) decreased by 10.5% (95% CI 6.9‐14.1, I2=64%). A meta‐regression analysis showed that the timing of assessment post‐KTx was the major source of the residual variance.ConclusionsThis meta‐analysis suggests a reduction of the overall arterial stiffness in patients with end‐stage kidney disease after KTx.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Reduction of Arterial Stiffness After Kidney Transplantation: A Systematic Review and Meta‐Analysis

Sidibé

Fortier

Desjardins

et al. 2017

JAHA

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“…PWV decreased insignificantly from 8.65 ± 2.02 m/s before to 8.62 ± 3.23 m/s at 3 months and to 8.06 ± 2.54 m/s at 6 months, while AIx (%) decreased significantly from 27.7 ± 11.3% before to 17.1 ± 9.0 % ( p < 0.05) at 3 months and 13.8 ± 12.4 % ( p < 0.05) at 6 months; a decrease in pulse pressure from 41.7 ± 13.9 before to 33.0 ± 11.1 ( p < 0.05) at 3 months and to 30.1 ± 9.8 mm Hg ( p < 0.05) at 6 months was also noted (64). In a more recent study, Ro et al (65) measured baPWV in 67 renal transplant recipients before surgery and 6 months, 1 and 2 years after it. baPWV prior to kidney transplantation and 6 months, 1 year, and 2 years after transplantation was 1,533 ± 261 cm/s, 1,417 ± 254 cm/s, 1,414 ± 285 cm/s, and 1,384 ± 233 cm/s, respectively.…”

Section: Studies Evaluating Arterial Stiffness Before and After Renalmentioning

confidence: 99%

Arterial Stiffness in Patients With Renal Transplantation; Associations With Co-morbid Conditions, Evolution, and Prognostic Importance for Cardiovascular and Renal Outcomes

Korogiannou

Xagas

Marinaki

et al. 2019

Front. Cardiovasc. Med.

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Patients with chronic kidney disease (CKD), particularly those with end-stage renal disease (ESRD), are at increased risk of cardiovascular events and mortality. The spectrum of arterial remodeling in CKD and ESRD includes atheromatosis of middle-sized conduit arteries and, most importantly, the process of arteriosclerosis, characterized by increased arterial stiffness of aorta and the large arteries. Longitudinal studies showed that arterial stiffness and abnormal wave reflections are independent cardiovascular risk factors in several populations, including patients with CKD and ESRD. Kidney transplantation is the treatment of choice for patients with ESRD, associated with improved survival and better quality of life in relation to hemodialysis or peritoneal dialysis. However, cardiovascular mortality in transplanted patients remains much higher than that in general population, a finding that is at least partly attributed to adverse lesions in the vascular tree of these patients, generated during the progression of CKD, which do not fully reverse after renal transplantation. This article attempts to provide an overview of the field of arterial stiffness in renal transplantation, discussing in detail available studies on the degree and the associations of arterial stiffness with other co-morbidities in renal transplant recipients, the prognostic significance of arterial stiffness for cardiovascular events, renal events and mortality in these individuals, as well as studies examining the changes in arterial stiffness following renal transplantation.

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Kidney transplantation improves arterial stiffness in patients with end-stage renal disease

et al. 2020

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Can Kidney Transplantation Improve Arterial Stiffness in End-Stage Renal Patients?

Cited by 13 publications

References 15 publications

Reduction of Arterial Stiffness After Kidney Transplantation: A Systematic Review and Meta‐Analysis

Reduction of Arterial Stiffness After Kidney Transplantation: A Systematic Review and Meta‐Analysis

Arterial Stiffness in Patients With Renal Transplantation; Associations With Co-morbid Conditions, Evolution, and Prognostic Importance for Cardiovascular and Renal Outcomes

Kidney transplantation improves arterial stiffness in patients with end-stage renal disease

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