Agmatine attenuates the discriminative stimulus and hyperthermic effects of methamphetamine in male rats

Thorn, David A.; Li, Jiuzhou; Qiu, Yanyan; Li, Jun-Xu

doi:10.1097/fbp.0000000000000244

Cited by 3 publications

(1 citation statement)

References 28 publications

(44 reference statements)

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“…Since DA plays a prominent role in the discriminative stimulus effects of indirect DA agonists (Kleven et al, 1990; Thorn et al, 2016), and since l -MA substituted for cocaine and d -MA in drug discrimination studies (Desai and Bergman, 2010; Kohut et al, 2016), it was possible that l -MA induces cocaine- or amphetamine-like effects on impulsivity. Impulsivity is a multifactorial phenomenon (Evenden, 1999; Winstanley et al, 2006), thus we used two behavioral tasks which measure distinct components.…”

Section: Discussionmentioning

confidence: 99%

Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats

et al. 2017

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Rationale Both l- and d-methamphetamine (l- and d-MA) are more potent to release norepinephrine (NE) than dopamine, and the selectivity is greater for l-MA than d-MA. Little is known of the in vivo pharmacology of l-MA. Objective This study compared the effects of l-MA and d-MA in assays of nociception, behavioral disruption, and impulsivity. Methods Antinociceptive effects of d- and l-MA were examined in two pain assays: the warm water tail withdrawal test for acute nociception and the von Frey test in complete Freund’s adjuvant (CFA)-treated rats for chronic inflammatory pain. Food-maintained operant responding and locomotion tests were used to assess generalized behavioral disruption. The 5-choice serial reaction time test (5-CSRTT) was used to assess drug-induced effects on impulse control. A delay discounting procedure was used to determine drug-induced changes in sensitivity to reinforcer delay (impulsive choice). Results l-MA (3.2–10 mg/kg) produced dose-dependent antinociception in both pain assays, decreased the rate of food-maintained operant responding, and decreased locomotor activity at a higher dose (17.8 mg/kg). In contrast, d-MA (0.32–3.2 mg/kg) did not produce antinociception in either assay, produced biphasic effects on response rate, and increased locomotor activity. In the 5-CSRTT, d-MA but not l-MA produced significant increase in premature responses. In the delay discounting procedure, both drugs did not affect the delay function at doses that did not increase omissions. Conclusions These data suggest that d- and l-MA have different behavioral profiles. Consideration should be given to these differences in future studies when l-MA is proposed for potential therapies.

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Section: Discussionmentioning

confidence: 99%

Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats

et al. 2017

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The hyperthermic response to intra-preoptic area administration of agmatine in male rats

Gao

et al. 2023

Journal of Thermal Biology

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Further pharmacological comparison of d-methamphetamine and l-methamphetamine in rats: abuse-related behavioral and physiological indices

Xue

Siemian

Zhu

et al. 2019

Behavioural Pharmacology

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Previous preclinical research suggests that l-methamphetamine (l -MA) has potential therapeutic utility to treat psychostimulant abuse. This study examined potential abuse-related and adverse physiological effects of d -MA and l -MA alone and in combination in rats, as these effects had not been previously characterized. Potential abuse-related effects were examined in locomotor sensitization and conditioned place preference paradigms. Body temperature was monitored to assess the physiological effects of these drugs or drug combinations. In the locomotor study, d-MA induced locomotor sensitization to both d-MA and l -MA. l -MA induced locomotor sensitization only to d-MA. Responses to a combination of l-MA and d -MA were not differentially affected by l-MA or d-MA conditioning. In the conditioned place preference study, d-MA and l -MA each induced significant place preference. l -MA did not attenuate d-MA-induced place preference. In the body temperature study, d-MA induced hyperthermia and l -MA induced hypothermia. In combination, l -MA did not affect d-MA-induced hyperthermia. These data suggest that l -MA alone produces less abuse-related and adverse physiological effects than d-MA, but modulates and is modulated by concurrent and subsequent d-MA exposure, which may enhance the abuse liability of both drugs. These findings should be considered when l -MA is proposed for replacement therapy.

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Agmatine attenuates the discriminative stimulus and hyperthermic effects of methamphetamine in male rats

Cited by 3 publications

References 28 publications

Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats

Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats

The hyperthermic response to intra-preoptic area administration of agmatine in male rats

Further pharmacological comparison of d-methamphetamine and l-methamphetamine in rats: abuse-related behavioral and physiological indices

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