Epidemic of Chemical Peritonitis in Patients on Continuous Ambulatory Peritoneal Dialysis: A Report from Western India

Jamale, Tukaram; Dhokare, Aniruddha; Satpute, K.; Kulkarni, R. U.; Usulumarty, Deepa; Billa, Vishwanath; Noronha, Santosh; Hase, Niwrutti

doi:10.3747/pdi.2015.00055

Perit Dial Int

2016

DOI: 10.3747/pdi.2015.00055

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Epidemic of Chemical Peritonitis in Patients on Continuous Ambulatory Peritoneal Dialysis: A Report from Western India

Tukaram Jamale

Aniruddha Dhokare

K. Satpute

et al.

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2024

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Cited by 1 publication

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Detections of Chemicals and Migratory Plastics in Peritoneal Dialysis Fluids

Panda,

Maloth,

Upadyayalu

et al. 2024

IJN

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Background: Peritoneal dialysis (PD) is an important modality of renal replacement therapy (RRT). Peritonitis and ultrafiltration failure are complications that have a long-term impact on PD patients. Besides touch contamination, procedural errors and clinical reasons of peritonitis, contaminants, and constituents of peritoneal dialysis fluids (PDFs) have been implicated in causing peritonitis and ultrafiltration failure. This study was aimed to test the PDFs in India for the presence of migratory plastics. Materials and Methods: PDFs from the two manufacturers in India were tested using liquid chromatography mass spectrometry (LCMS) and gas chromatography mass spectrometry (GCMS) with headspace analysis (volatile compounds) and pyrolysis of plastics (polymer compounds). The storage conditions and handling were uniform. Results: The results revealed impurities of acetate compounds and aldehyde derivatives of glucose degradation products (GDPs) with contaminants and leachable plastics. There were high levels of GDP derivative in the form of 5-hydroxymethylfurfural compounds (5-HMF). The analysis revealed the presence of plastic softeners in very high concentrations. Conclusion: The study unmasks the presence of chemicals and GDPs that can be implicated in pathogenesis of sterile peritonitis and ultrafiltration failure. The study demonstrated the presence of leachable plastics. In conclusion, LCMS and GCMS studies can be used to test PDFs for unwanted chemicals prior to human use.

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Detections of Chemicals and Migratory Plastics in Peritoneal Dialysis Fluids

Panda,

Maloth,

Upadyayalu

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

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Epidemic of Chemical Peritonitis in Patients on Continuous Ambulatory Peritoneal Dialysis: A Report from Western India

Cited by 1 publication

References 6 publications

Detections of Chemicals and Migratory Plastics in Peritoneal Dialysis Fluids

Detections of Chemicals and Migratory Plastics in Peritoneal Dialysis Fluids

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