Percent slope analysis of dynamic magnetic resonance imaging for assessment of chemotherapy response of osteosarcoma or Ewing sarcoma: systematic review and meta-analysis

Kubo, Toru; Furuta, Takeshi; Johan, Muhammad Phetrus; Adachi, Nobuo; Ochi, Mitsuo

doi:10.1007/s00256-016-2410-y

Cited by 34 publications

(32 citation statements)

References 34 publications

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“…The survival of patients with osteosarcoma has improved considerably since the 1980s with the advent of multiagent chemotherapy, with overall survival of roughly 20% in metastatic patients and 70% in non-metastatic patients 9 , 10 . If patients with poor survival can be identified preoperatively, personalized treatment plans may be helpful in decision making.…”

Section: Introductionmentioning

confidence: 99%

A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy

Liu

Wang

et al. 2020

Sci Rep

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The prognostic factors for survival among patients with secondary osteosarcoma remain unclear. The aim of this study was to develop a practical nomogram for predicting cancer-specific survival (CSS) in patients with osteosarcoma as a secondary malignancy. The surveillance, epidemiology, and end results database was used for the identification of osteosarcoma cases. The total sample comprised 5860 cases of primary osteosarcoma and 268 cases of secondary osteosarcoma during the period from 1973 to 2015. The CSS and overall survival (OS) of primary and secondary osteosarcomas were analyzed. The predictors of CSS for secondary osteosarcoma were identified and integrated to build a nomogram. Validation of the nomogram was performed using concordance index (C-index) and calibration plots. The results indicated that patients with secondary osteosarcoma had poorer CSS and OS than patients with primary osteosarcoma. The nomogram model exhibited high discriminative accuracy in the training cohort (C-index = 0.826), which was confirmed in the internal validation cohort (C-index = 0.791). In addition, the calibration plots confirmed good concordance for prediction of CSS at 3, 5, and 10 years. In conclusion, we developed a practical nomogram that provided individual predictions of CSS for patients with secondary osteosarcoma. This nomogram may help clinicians with prognostic evaluations and with the development of individualized therapies for this aggressive disease.

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Section: Introductionmentioning

confidence: 99%

A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy

Liu

Wang

et al. 2020

Sci Rep

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“…However, this valuable standard criterion is available only following surgery, which means that histological evaluation of tumor necrosis during the course of chemotherapy requires repeated invasive biopsies. The quantitative evaluation of preoperative radiological changes using diffusion-weighted imaging (DWI), dynamic magnetic resonance imaging, thallium-201 scintigraphy and positron emission tomography with computed tomography (PET/CT) has been challenged (8)(9)(10)(11)(12). The operative treatment and neoadjuvant chemotherapy of suspected poor responders may then be intensified earlier, potentially increasing their survival rates and decreasing the risk rates of iatrogenic toxicity.…”

Section: Introductionmentioning

confidence: 99%

Value of diffusion-weighted imaging for evaluating chemotherapy response in osteosarcoma: A meta-analysis

Kubo

Furuta

Johan

et al. 2017

Molecular and Clinical Oncology

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Abstract. The histological examination of the tumor necrosis upon surgery remains the most reliable prognostic factor for osteosarcoma. However, the detection of more early prognostic factors is desirable in order to increase the survival rates and decrease the risk rates for iatrogenic toxicity. The purpose of the current systematic review and meta-analysis was to provide an up-to-date summary of the role of diffusion-weighted imaging (DWI) for the preoperative assessment of the chemotherapy response in osteosarcoma. Articles evaluating DWI for the preoperative assessment of the chemotherapy response of osteosarcoma were systematically searched for in four electronic literature databases. The mean difference in apparent diffusion coefficient (ADC) following neoadjuvant chemotherapy between good and poor histological responders was assessed in 5 studies. The mean difference in the ADC ratio (the percentage change in ADC between post-neoadjuvant and pre-neoadjuvant chemotherapy) reported in 3 studies was also assessed. Five articles with 106 patients fulfilled all of the inclusion criteria for the meta-analysis. Significant mean differences were found between good and poor responders in the ADC in the 5 studies (P=0.03) and the ADC ratio in the 3 studies (P<0.00001). The good responders demonstrated a higher ADC and a higher ADC ratio than the poor responders. DWI performed with ADC values was useful for predicting the chemotherapeutic response of osteosarcoma. This method may have promising potential as a preoperative non-invasive modality.

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“…The importance of accurate imaging at initial diagnosis and after preoperative chemotherapy, however, cannot be overstated. A detailed review of local imaging would be beyond the scope of this article and the reader is referred to the recent literature 15– 19 .…”

Section: Advances In Imagingmentioning

confidence: 99%

Advances in the management of osteosarcoma

et al. 2016

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Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is usually a high-grade malignancy characterized by a very high risk for the development of pulmonary metastases. High-grade osteosarcomas are usually treated by preoperative and postoperative chemotherapy and surgery, with a very limited number of active agents available. Rarer lower-grade variants such as parosteal and periosteal osteosarcoma or low-grade central osteosarcoma are treated by surgery only. Imaging to search for possible metastases focuses on the lung. Computed tomography is the most sensitive method but cannot reliably distinguish small metastases from benign lesions. Advances of local imaging and surgical reconstruction now allow the use of limb-salvage in an ever-increasing proportion of patients. While still troubled by complications, non-invasive endoprosthesis-lengthening mechanisms have led to an increased uptake of limb-salvage, even for young, skeletally immature patients. Radiotherapy is employed when osteosarcomas cannot be removed with clear margins, but very high doses are required, and both proton and carbon-ion radiotherapy are under investigation. Unfortunately, the past 30 years have witnessed few, if any, survival improvements. Novel agents have not led to universally accepted changes of treatment standards. In patients with operable high-grade osteosarcomas, the extent of histological response to preoperative chemotherapy is a significant predictive factor for both local and systemic control. Attempts to improve prognosis by adapting postoperative treatment to response, recently tested in a randomized, prospective setting by the European and American Osteosarcoma Study Group, have not been proven to be beneficial. Many agree that only increased knowledge about osteosarcoma biology will lead to novel, effective treatment approaches and will be able to move the field forward.

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Percent slope analysis of dynamic magnetic resonance imaging for assessment of chemotherapy response of osteosarcoma or Ewing sarcoma: systematic review and meta-analysis

Abstract: The slope of the time intensity curve derived from dynamic MRI was useful for evaluating the histological response of patients to neoadjuvant chemotherapy in osteosarcoma or Ewing sarcoma.

Cited by 34 publications

References 34 publications

A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy

A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy

Value of diffusion-weighted imaging for evaluating chemotherapy response in osteosarcoma: A meta-analysis

Advances in the management of osteosarcoma

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