Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome

Shinmei, Yasuhiro; Nitta, Tsuyoshi; Saitô, Hiroshi; Ohguchi, Takeshi; Kijima, Riki; Chin, Shinki; Ishida, Susumu

doi:10.1167/iovs.16-19220

Cited by 34 publications

(25 citation statements)

References 43 publications

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“…The first study that evaluated continuously the IOP in patients with OSAS and used SENSIMED triggerfish as a IOP sensor was done by Shinmei and collaborators. They have examined the impact of apnea-hypopnea events and IOP values in seven patients, reporting a significant decrease in the IOP associated to apnea-hypopnea events in four out of seven patients [54]. Interestingly these fluctuations have no impact in the global IOP curves [54], showed a similar pattern to those obtained in our study ( Fig 5).…”

Section: Plos Onesupporting

confidence: 85%

Continuous intraocular pressure monitoring in patients with obstructive sleep apnea syndrome using a contact lens sensor

et al. 2020

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PurposeTo analyse nocturnal intraocular pressure (IOP) fluctuations in patients with obstructive sleep apnea syndrome (OSAS) using a contact lens sensor (CLS) and to identify associations between the OSAS parameters determined by polysomnographic study (PSG) and IOP changes. MethodProspective, observational study. Twenty participants suspected of having OSAS were recruited. During PSG study, IOP was monitored using a CLS placed in the eye of the patient. The patients were classified according to the apnea-hypopnea index (AHI) in two categories, severe (>30) or mild/moderate (<30) OSAS. We evaluated several parameters determined by the IOP curves, including nocturnal elevations (acrophase) and plateau times in acrophase (PTs) defined by mathematical and visual methods. ResultsThe IOP curves exhibited a nocturnal acrophase followed by PTs of varying extents at which the IOP remained higher than daytime measurement with small variations. We found significant differences in the length of the PTs in patients with severe OSAS compared to those with mild/moderate disease (P = 0.032/P = 0.028). We found a positive correlation between PTs and OSAS severity measured by the total number of apneic events (r = 0.681/ 0.751 P = 0.004/0.001) and AHI (r = 0.674/0.710, P = 0.004/0.002). Respiratory-related arousal and oxygen saturation also were associated significantly with the IOP PT length. PLOS ONEPLOS ONE | https://doi.org/10.1371/journal.pone.

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Section: Plos Onesupporting

confidence: 85%

Continuous intraocular pressure monitoring in patients with obstructive sleep apnea syndrome using a contact lens sensor

et al. 2020

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“…Furthermore, recent findings have complicated our view of IOP changes in SAS. Contact lens sensorbased continuous IOP monitoring has shown that IOP levels decline significantly during apnoea events (Shinmei et al 2016). Thus, although it is clear that SAS and glaucoma are related, the role of IOP changes in this relationship is unknown.…”

Section: Discussionmentioning

confidence: 99%

The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome

Yamada

Himori

Kunikata

et al. 2018

Acta Ophthalmologica

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“…16 Studies have demonstrated an association with OSA and both NTG and OAG. 5,9,17 A meta-analysis of 3 case-control studies, including 711 cases and 6,709 controls, found an odds ratio (OR) of 2.46 for the association between OSA and glaucoma. Among cohort studies, the same meta-analysis found an OR of 1.43.…”

Section: G L Auco M Amentioning

confidence: 99%

“…Research has sought to evaluate changes in IOP during sleep utilizing wireless contact lens sensors, which continuously monitor IOP. 17 Shinmei et al implemented this technique to monitor nocturnal IOP in patients with OSA; however, their findings seemingly contradicted the prevailing association between OSA and glaucoma, showing a statistically significant decrease in IOP during hypopneic and apneic events. 17 The authors explained that the decrease in IOP during apneic and hypopneic events likely resulted from negative intrathoracic pressure created by an attempted inspiration against a blocked airway (opposite the effect of Valsalva on IOP).…”

Section: G L Auco M Amentioning

confidence: 99%

Ocular Manifestations of Obstructive Sleep Apnea

Santos

Hofmann

2017

Journal of Clinical Sleep Medicine

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Study Objectives: Obstructive sleep apnea (OSA) incurs a host of systemic side effects. The eyes are particularly susceptible to both mechanical and vascular sequelae of the disease. This paper outlines the ocular manifestations of sleep apnea. The authors hope to increase awareness of the ocular complications of this common disorder and increase communication and co-management between eye-care providers and sleep specialists alike. Methods: Data were collected from PubMed and the Brown University Library Collection. Results: Twenty-two papers were included in this review to address floppy eyelid syndrome, nonarteritic anterior ischemic optic neuropathy, central serous retinopathy, retinal vein occlusion, and glaucoma. We used three meta-analyses and several cross-sectional cohort and case-control studies that investigate the aforementioned conditions and their associations with OSA. Conclusions: Hypoxia induced by nightly cessation of breathing increases patients' risk of coronary artery disease, heart failure, stroke, and other conditions. As with many maladies detrimental to vascular health, obstructive sleep apnea affects the eye and ocular adnexa. This paper summarizes the current evidence implicating OSA in these ocular maladies and highlights their proposed mechanisms. The authors describe ocular pathology which sleep specialists may encounter. We encourage more aggressive attention to ocular symptoms in patients with sleep apnea to prevent vision-threatening complications. Further research should investigate how sleep apnea treatment affects these ocular findings and identify which sleep apnea patients are most prone to developing ocular pathology. Keywords: eye diseases, obstructive sleep apnea, ophthalmology Citation: Santos M, Hofmann RJ. Ocular manifestations of obstructive sleep apnea.

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Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome

Cited by 34 publications

References 43 publications

Continuous intraocular pressure monitoring in patients with obstructive sleep apnea syndrome using a contact lens sensor

Continuous intraocular pressure monitoring in patients with obstructive sleep apnea syndrome using a contact lens sensor

The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome

Ocular Manifestations of Obstructive Sleep Apnea

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