Disturbances of Agency and Ownership in Schizophrenia: An Auditory Verbal Event Related Potentials Study

Bühler, Tim; Kindler, Jochen; Schneider, Rahel C.; Strik, Werner; Dierks, Thomas; Hubl, Daniela; Koenig, Thomas

doi:10.1007/s10548-016-0495-1

Cited by 13 publications

(6 citation statements)

References 30 publications

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“…In other words in HC, self-generated (and therefore highly predictable) sounds give rise to suppressed responses, thus allowing speakers to pay better attention to sounds in the external environment [ 35 , 37 ], indicative of a primordial biological basis for self-agency that is essential for normal interactions with outside reality [ 37 , 39 , 40 ]. By contrast, in SZ, reduced suppression to self-generated actions (i.e., during speaking, for example) [ 31 , 37 , 41 – 43 ] suggests patients may have noisier auditory cortical signal to begin with, making it more difficult to make reliable computations about the comparisons between predicted and actual auditory feedback while speaking. This auditory cortical signal is sent to higher order regions within PFC/mPFC [ 12 , 36 ] that are considered to be critical for computing the reliance that needs to be placed on self-predictions [ 12 ], in order to mediate higher-order agency judgments [ 19 , 20 ].…”

Section: Self-prediction Mechanisms Are Impaired In Schizophreniamentioning

confidence: 99%

The Role of the Medial Prefontal Cortex in Self-Agency in Schizophrenia

Subramaniam

2021

J Psychiatry Brain Sci

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Schizophrenia is a disorder of the self. In particular, patients show cardinal deficits in self-agency (i.e., the experience and awareness of being the agent of one’s own thoughts and actions) that directly contribute to positive psychotic symptoms of hallucinations and delusions and distort reality monitoring (defined as distinguishing self-generated information from externally-derived information). Predictive coding models suggest that the experience of self-agency results from a minimal prediction error between the predicted sensory consequence of a self-generated action and the actual outcome. In other words, the experience of self-agency is thought to be driven by making reliable predictions about the expected outcomes of one’s own actions. Most of the agency literature has focused on the motor system; here we present a novel viewpoint that examines agency from a different lens using distinct tasks of reality monitoring and speech monitoring. The self-prediction mechanism that leads to self-agency is necessary for reality monitoring in that self-predictions represent a critical precursor for the successful encoding and memory retrieval of one’s own thoughts and actions during reality monitoring to enable accurate self-agency judgments (i.e., accurate identification of self-generated information). This self-prediction mechanism is also critical for speech monitoring where we continually compare auditory feedback (i.e., what we hear ourselves say) with what we expect to hear. Prior research has shown that the medial prefrontal cortex (mPFC) may represent one potential neural substrate of this self-prediction mechanism. Unfortunately, patients with schizophrenia (SZ) show mPFC hypoactivity associated with self-agency impairments on reality and speech monitoring tasks, as well as aberrant mPFC functional connectivity during intrinsic measures of agency during resting states that predicted worsening psychotic symptoms. Causal neurostimulation and neurofeedback techniques can move the frontiers of schizophrenia research into a new era where we implement techniques to manipulate excitability in key neural regions, such as the mPFC, to modulate patients’ reliance on self-prediction mechanisms on distinct tasks of reality and speech monitoring. We hypothesize these findings will show that mPFC provides a unitary basis for self-agency, driven by reliance on self-prediction mechanisms, which will facilitate the development of new targeted treatments in patients with schizophrenia.

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Section: Self-prediction Mechanisms Are Impaired In Schizophreniamentioning

confidence: 99%

The Role of the Medial Prefontal Cortex in Self-Agency in Schizophrenia

Subramaniam

2021

J Psychiatry Brain Sci

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“…Furthermore, altered effective connectivity between the left superior temporal and anterior cingulate cortex is associated with the tendency to perceive one's own voice as generated by another person (Mechelli et al, 2007). Altered function of the anterior cingulate cortex may hence contribute to a decreased sense of agency over the sensory consequences of one's own actions (Asai and Tanno, 2013;Bühler et al, 2016;Sugimori et al, 2011). Accordingly, the self-generated voice would be evaluated as external ('this is not my voice') in voice hearers (Allen et al, 2006(Allen et al, , 2004Brébion et al, 2016;Johns et al, 2010;Pinheiro et al, 2016).…”

Section: Altered Self-awareness and Agency?mentioning

confidence: 99%

Cerebellar circuitry and auditory verbal hallucinations: An integrative synthesis and perspective

Pinheiro

Schwartze

Kotz

2020

Neuroscience & Biobehavioral Reviews

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People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

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“…Mathalon et al (39) found that reduced N100 suppression was correlated with unusual thought content in one of two patient groups. Bühler et al (34), by contrast, found no correlation between Positive and Negative Syndrome Scale (PANSS) scores and either N100 amplitude or the amplitude of an unidentified "late component" that appears to be a P200. Perez et al (40) likewise found no correlation between N100 suppression and any of four psychopathology subscales.…”

Section: Event-related Potentials Datamentioning

confidence: 96%

Abnormal ERPs and Brain Dynamics Mediate Basic Self Disturbance in Schizophrenia: A Review of EEG and MEG Studies

Hamilton

Northoff

2021

Front. Psychiatry

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Background: Interest in disordered sense of self in schizophrenia has recently re-emerged in the literature. It has been proposed that there is a basic self disturbance, underlying the diagnostic symptoms of schizophrenia, in which the person's sense of being a bounded individual continuous through time loses stability. This disturbance has been documented phenomenologically and at the level of cognitive tasks. However, the neural correlates of basic self disorder in schizophrenia are poorly understood.Methods: A search of PubMed was used to identify studies on self and schizophrenia that reported EEG or MEG data.Results: Thirty-three studies were identified, 32 using EEG and one using MEG. Their operationalizations of the self were divided into six paradigms: self-monitoring for errors, proprioception, self-other integration, self-referential processing, aberrant salience, and source monitoring. Participants with schizophrenia were less accurate on self-referential processing tasks and had slower response times across most studies. Event-related potential amplitudes differed across many early and late components, with reduced N100 suppression in source monitoring paradigms being the most replicated finding. Several studies found differences in one or more frequency band, but no coherent overall finding emerged in this area. Various other measures of brain dynamics also showed differences in single studies. Only some of the study designs were adequate to establish a causal relationship between the self and EEG or MEG measures.Conclusion: The broad range of changes suggests a global self disturbance at the neuronal level, possibly carried over from the resting state. Further studies that successfully isolate self-related effects are warranted to better understand the temporal-dynamic and spatial-topographic basis of self disorder and its relationship to basic self disturbance on the phenomenological level.

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Disturbances of Agency and Ownership in Schizophrenia: An Auditory Verbal Event Related Potentials Study

Cited by 13 publications

References 30 publications

The Role of the Medial Prefontal Cortex in Self-Agency in Schizophrenia

The Role of the Medial Prefontal Cortex in Self-Agency in Schizophrenia

Cerebellar circuitry and auditory verbal hallucinations: An integrative synthesis and perspective

Abnormal ERPs and Brain Dynamics Mediate Basic Self Disturbance in Schizophrenia: A Review of EEG and MEG Studies

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