Quality of Life Decrements after Stroke

Abstract

and the UK. Visual Analog Scale (VAS) scores were obtained to validate TTO scores. TTO scores were converted into utility values. Results: The highest mean TTO utility scores (range 0.66-0.82) were observed for the anchor HS (minimal disease activity) across all countries. All flare HS were associated with a disutility compared with the anchor HS: mild flare HS (0.55-0.71), moderate flare HS (0.38-0.53), severe renal flare HS (0.33-0.45), severe Central Nervous System (CNS) flare HS (0.30-0.45) and severe generalised flare HS (0.19-0.33). Significant differences were reported between the anchor state and each flare state across all countries (p< 0.05). Mean VAS scores followed the same trend. The severe generalised flare HS received the lowest mean TTO utility score across all six countries suggesting that the perceived day-to-day impact of a severe generalised flare was greater than a severe CNS or severe renal flare. ConClusions: These results show that a decrease in utility, representing a detrimental impact on HRQoL, was observed with increasing severity of flare. These results could be applied in cost-utility analyses for interventions for SLE. QL2

Cost-effectiveness of endovascular thrombectomy in patients with acute ischemic stroke

“…It is a commonly used tool to measure the degree of dependency or level of global disability after a stroke (0 implies no disability; 6 indicates dead). The global disability score is strongly connected to the amount of costs 9 and quality of life 5 in patients, which makes it ideal for our analysis. The randomized, multicenter studies ESCAPE, MR CLEAN, REVASCAT, and SWIFT PRIME collected mRS data after 90 days as the primary endpoint while EXTEND-IA had mRS at 90 days as secondary endpoint.…”

“…Stroke is a leading cause of serious long-term disability worldwide [1][2][3][4] , resulting in decreased quality of life 5 , mortality 6 , increased burden of informal caregivers 7 , and high costs to the society 8 . A primary predictor of the costs associated with strokes is the functional outcome after the stroke 9 .…”

Health Economic Evaluations of Screening Programs - Applications and Method Improvements

“…Stroke is, as mentioned above, a leading cause of serious long-term disability worldwide, [63][64][65] resulting in decreased quality of life and survival, [45,66] increased burden on informal caregivers, [67] and high costs to the society. [47] A primary predictor of the costs associated with strokes is the functional outcome after the stroke.…”

“…The global disability has a strong connection with the amount of costs and quality of life in patients, which makes it a suitable tool for this analysis. [66,68] The randomised, multicentre studies ESCAPE, MR CLEAN, RE-VASCAT, and SWIFT PRIME all used mRS after 90 days as the primary endpoint while EXTEND-IA had mRS at 90 days as secondary endpoint. Details of the pooled data from the five studies, which were used in the model as the base-case scenario, are presented in Figure 13.…”

“…[130] Utility decrements based on the global disability (mRS) after stroke and re-stroke were used throughout the model. [66] Since the observational study that was used in our model was only available as an abstract, the sensitivity of this parameter was tested using the only other published source of data we could identify. [136] …”