First insights into the genetic diversity of Echinococcus granulosus sensu stricto (s.s.) in Serbia

Debeljak, Zoran; Boufana, Belgees; Interisano, Maria; Vidanović, Dejan; Kulišić, Zoran; Casulli, Adriano

doi:10.1016/j.vetpar.2016.04.007

Cited by 17 publications

(12 citation statements)

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“…5): the 212 samples analysed represented a total of 171 haplotypes (over-all haplotype diversity 0.994; Table 2). High genetic diversity within E. granulosus s.s. has also been reported in various parts of the world based on shorter sequence lengths (e.g., Casulli et al, 2012;Sharma et al, 2013;Alvarez Rojas et al, 2016;Debeljak et al, 2016;Hassan et al, 2017) and >8000 bp of mtDNA (Kinkar et al, 2016;Laurimäe et al, 2016). However, this is the first study to demonstrate the diversity of G1 based on near-complete mitogenome data sets on a vast geographic scale.…”

Section: Discussionsupporting

confidence: 54%

Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1

Kinkar

Laurimäe

Acosta‐Jamett

et al. 2018

International Journal for Parasitology

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Section: Discussionsupporting

confidence: 54%

Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1

Kinkar

Laurimäe

Acosta‐Jamett

et al. 2018

International Journal for Parasitology

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“…After decades of research, G3 has now been identified from a significantly wider geographic range (Australia, North Africa, the Middle East, South America, Southern Europe and parts of Asia). While relatively few cases of G3 have been reported in South America, Australia and North Africa (M'rad et al 2010; de la Rue et al 2011; Espinoza et al 2014; Alvarez Rojas et al 2016; Zait et al 2016), significantly higher prevalence is characteristic to Iran, Italy, Pakistan, Serbia and especially India (Capuano et al 2006; Busi et al 2007; Pednekar et al 2009; Latif et al 2010; Sharbatkhori et al 2011; Sharma et al 2013 a , b ; Debeljak et al 2016; Ehsan et al 2017). Genotype G1 is globally the most prevalent genotype, whereas G3 is generally less frequent (e.g.…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity and phylogeography of the elusive, but epidemiologically importantEchinococcus granulosussensu stricto genotype G3

et al. 2018

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Cystic echinococcosis (CE) is a severe parasitic disease caused by the species complex Echinococcus granulosus sensu lato. Human infections are most commonly associated with E. granulosus sensu stricto (s.s.), comprising genotypes G1 and G3. The objective of the current study was to provide first insight into the genetic diversity and phylogeography of genotype G3. Despite the epidemiological importance of the genotype, it has remained poorly explored due to the ambiguity in the definition of the genotype. However, it was recently demonstrated that long sequences of mitochondrial DNA (mtDNA) provide a reliable method to discriminate G1 and G3 from each other. Therefore, we sequenced near-complete mtDNA of 39 G3 samples, covering most of the known distribution range and host spectra of the genotype. The phylogenetic network revealed high genetic variation within E. granulosus s.s. G3 and while G3 is significantly less prevalent worldwide than G1, the genetic diversity of both of the genotypes is equally high. We also present the results of the Bayesian phylogeographic analysis, which yielded several well-supported diffusion routes of genotype G3 originating from Turkey and Iran, suggesting the Middle East as the origin of the genotype.

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“…genotypes circulating in livestock, dogs and humans in those geographical regions. In Serbia, E. granulosus s.s. has been detected in sheep, while E. granulosus s.s. G1 and E. canadensis G7 have been identified in humans, cattle and pigs [ 15 , 33 , 34 ]. Infections with E. granulosus s.s. have been characterized in dogs and cattle in Kosovo [ 15 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Echinococcus granulosus sensu lato from Humans in Slovenia

et al. 2020

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The larval form of tapeworms of the Echinococcus granulosus sensu lato species cluster cause an important zoonotic infection, cystic echinococcosis (CE). Molecular characterization of the cluster’s isolates from different hosts greatly contributes to a better understanding of its transmission dynamics. To date, no genetic information is available on CE in Slovenia. In this work, we characterized isolates from human CE cases. Parasite samples from 18 patients were collected, together with the patients’ demographic and clinical data. Genomic DNA was analyzed by conventional PCR and sequencing at four mitochondrial loci (cytochrome c oxidase subunit 1, cox1; NADH dehydrogenase subunit 1, nad1; NADH dehydrogenase subunit 5, nad5; and small ribosomal RNA, rrnS). Thirteen isolates were successfully amplified and sequenced. Seven (58.8%) patients were infected with E. granulosus sensu stricto (s.s.) G1, five (38.5%) with E. canadensis G7 and one (7.7%) with E. granulosus s.s. G3. Echinococcus canadensis G7, the pig genotype, was identified exclusively in autochthonous Slovenes, while the patients originating from the Western Balkans were all infected with E. granulosus s.s. Our findings suggest that pigs are important intermediate hosts for human CE in Slovenia.

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First insights into the genetic diversity of Echinococcus granulosus sensu stricto (s.s.) in Serbia

Cited by 17 publications

References 29 publications

Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1

Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1

Genetic diversity and phylogeography of the elusive, but epidemiologically importantEchinococcus granulosussensu stricto genotype G3

Molecular Characterization of Echinococcus granulosus sensu lato from Humans in Slovenia

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