Muscle regeneration after sepsis

Bouglé, Adrien; Rocheteau, Pierre; Sharshar, Tarek; Chrétien, Fabrice

doi:10.1186/s13054-016-1308-3

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…Muscle wasting is a major concern for sepsis patients in the ICU. Numerous factors, most notably muscle unloading during bedrest, insufficient nutrition, pharmacologic exposures, and imbalanced protein catabolism and synthesis, have been shown to contribute to sepsis-mediated atrophy (Schefold et al, 2010; Schreiber et al, 2018; Eikermann et al, 2006; Spranger et al, 2003; Dres et al, 2017; Yu et al, 2018; Lang et al, 2007; Yang et al, 2018; Vary and Kimball, 1992; Puthucheary et al, 2013; Bouglé et al, 2016). However, clinical interventions with early mobilization (Denehy et al, 2013; Morris et al, 2016; Moss et al, 2016; Tipping et al, 2017) and nutritional support (Goossens et al, 2017; Hermans et al, 2013; Ogilvie and Larsson, 2014) have not improved long-term outcomes, and some studies even show negative effects of high protein delivery on muscle wasting (Puthucheary et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

Owen

Patel

Smith

et al. 2019

eLife

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Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness, we first surpassed a critical barrier by establishing a murine model of sepsis with ICU-like interventions that allows for the study of survivors. We show that sepsis survivors have profound weakness for at least 1 month, even after recovery of muscle mass. Abnormal mitochondrial ultrastructure, impaired respiration and electron transport chain activities, and persistent protein oxidative damage were evident in the muscle of survivors. Our data suggest that sustained mitochondrial dysfunction, rather than atrophy alone, underlies chronic sepsis-induced muscle weakness. This study emphasizes that conventional efforts that aim to recover muscle quantity will likely remain ineffective for regaining strength and improving quality of life after sepsis until deficiencies in muscle quality are addressed.

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Section: Discussionmentioning

confidence: 99%

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

Owen

Patel

Smith

et al. 2019

eLife

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“…It is well accepted that the ICU-acquired weakness (ICU-AW) is clinically characterized by bilateral and symmetrical limb weakness [43]. This may be a manifestation of a rising catabolic state in septic patients who fail to rapidly recover from an acute event.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

Custodero

Ghita

et al. 2019

Crit Care

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Background: Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, and catabolism syndrome predisposing them to long-term functional limitations and higher mortality. There is a need to identify biomarkers that can predict long-term worsening of physical function to be able to act early and prevent mobility loss. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a well-accepted biomarker of cardiac overload, but it has also been shown to be associated with long-term physical function decline. We explored whether NT-proBNP blood levels in the acute phase of sepsis are associated with physical function and muscle strength impairment at 6 and 12 months after sepsis onset. Methods: This is a retrospective analysis conducted in 196 sepsis patients (aged 18-86 years old) as part of the University of Florida (UF) Sepsis and Critical Illness Research Center (SCIRC) who consented to participate in the 12-month follow-up study. NT-proBNP was measured at 24 h after sepsis onset. Patients were followed to determine physical function by short physical performance battery (SPPB) test score (scale 0 to12-higher score corresponds with better physical function) and upper limb muscle strength by hand grip strength test (kilograms) at 6 and 12 months. We used a multivariate linear regression model to test an association between NT-proBNP levels, SPPB, and hand grip strength scores. Missing followup data or absence due to death was accounted for by using inverse probability weighting based on concurrent health performance status scores. Statistical significance was set at p ≤ 0.05. Results: After adjusting for covariates (age, gender, race, Charlson comorbidity index, APACHE II score, and presence of CCI condition), higher levels of NT-proBNP at 24 h after sepsis onset were associated with lower SPPB scores at 12 months (p < 0.05) and lower hand grip strength at 6-month (p < 0.001) and 12-month follow-up (p < 0.05). Conclusions: NT-proBNP levels during the acute phase of sepsis may be a useful indicator of higher risk of long-term impairments in physical function and muscle strength in sepsis survivors.

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“…Although the erosion of lean body mass and skeletal muscle loss have been studied [190,191], examination of sepsis-induced changes in fat mass and adipocyte biology has been less thorough. The same group also showed that white adipose tissue stimulated continued inflammation with activation of the inflammasome, the ubiquitinproteasome pathway, and autophagy, even when the infectious source was excised.…”

Section: What Is Knownmentioning

confidence: 99%

The surviving sepsis campaign: basic/translational science research priorities

Deutschman

Hellman

Ferrer

et al. 2020

ICMx

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Objectives Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Data sources Original paper, search of the literature. Study selection This study is selected by several members of the original task force with specific expertise in basic/translational science. Data extraction and data synthesis are not available. Conclusions In the first of a series of follow-up reports to the original paper, several members of the original task force with specific expertise provided a more in-depth analysis of the five identified priorities directly related to basic/translational science. This analysis expounds on what is known about the question and what was identified as priorities for ongoing research. It is hoped that this analysis will aid the development of future research initiatives.

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Muscle regeneration after sepsis

Cited by 13 publications

References 18 publications

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

The surviving sepsis campaign: basic/translational science research priorities

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