“…Ee cells are major sensors of luminal content ( Engelstoft et al., 2008 , Moran-Ramos et al., 2012 ) and coordinate gastrointestinal and systemic responses through secretory programs ( Steinert and Beglinger, 2011 ) that affect gut motility, digestion, appetite, glucose homeostasis, and energy expenditure ( Campbell and Drucker, 2013 , Field et al., 2010 , Gribble and Reimann, 2016 , Park et al., 2016 , Worthington et al., 2017 , Zietek and Daniel, 2015 ). Our previous work revealed a local role for ee-derived Bursα in the adult midgut, which was necessary and sufficient to prevent ISC proliferation ( Scopelliti et al., 2014 , Scopelliti et al., 2016 ). Knocking down bursα from ee cells resulted in ISC hyperproliferation in the normally quiescent homeostatic adult midgut, while bursα overexpression suppressed the characteristic proliferative response of ISCs following damage and upon aging ( Scopelliti et al., 2014 , Scopelliti et al., 2016 ).…”