“…In addition, our data coherently reached a conclusion that pyrimidine deprivation mediated by GLDC inhibition/depletion could amplify the antiviral response of type I IFN and ISGs and suppress viral replication, which reinforced the link between pyrimidine biosynthesis pathway and antiviral status as consistently demonstrated in other studies (Hoffmann et al , ; Wang et al , ; Cheung et al , ). More recently, a pyrimidine inhibitor identified as a broad‐spectrum antiviral was found to activate RIG‐I (Chung et al , ), an essential cellular sensor to mount innate immune response in influenza virus infection (Loo et al , ). However, the detailed mechanism linking pyrimidine deprivation and the boosted antiviral response definitely requires further study.…”