Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats

Atochin, Dmitriy N.; Чернышева, Г. А.; Smol’yakova, V. I.; Osipenko, Anton N.; Логвинов, С. В.; Zhdankina, A. A.; Sysolyatin, S. V.; Kryukov, Yuri A.; Anfinogenova, Yana; Плотникова, Т. М.; Плотников, М. Б.

doi:10.1016/j.phymed.2016.03.015

Cited by 26 publications

(30 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zhao et al [36], for example, revealed that Sal was able to make rat mesenchymal stem cells (MSCs) to differentiate into dopaminergic neurons. Focal cerebral ischemia-reperfusion injury in rat model was protected by Sal pretreatment possibly involving its ability to reduce the permeability of blood brain barrier [15,20]. Following experimental traumatic brain injury in mice, Sal administration produced behavioral improvement and decreased apoptosis via modulation of PI3K/Akt signaling.…”

Section: Discussionmentioning

confidence: 99%

“…It also induced neurogenesis in dentate gyrus of the hippocampus [39] and prevented death of dopaminergic neurons induced by 6-OHDA (6-hydroxydopamine) [22]. Recent studies also showed neuroprotective potential of Sal metabolite -p-tyrosol -after global cerebral ischemia in rats [20] or its protective [40]. None of these studies, however, did include an attempt to determine the effect of salidroside on the course of alcohol tolerance in vivo.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

et al. 2018

View full text Add to dashboard Cite

SummaryIntroduction: In recent years, the search for potential neuroprotective properties of salidroside and its ability to influence the activity of nervous system become the subject of intense studies of many research groups. None of these studies, however, include an attempt to determine the effect of salidroside on the course of alcohol tolerancein vivo.Objective: The aim of this study was to investigate the ability of salidroside to inhibit the development of alcohol tolerance in rats, determining whether the effect of its action may occur in a dose-dependent manner, reducing both metabolic and central tolerance without affecting body temperature in control rats.Methods: Male Wistar rats were injected daily with ethanol at a dose of 3 g/kg for 9 consecutive days to produce ethanol tolerance. Salidroside in two doses (4.5 mg/kg and 45 mg/kgb.w.) orvehiculumwas administered orally. On the 1st, 3rd, 5th and 8th day a hypothermic effect of ethanol was measured, while the loss of righting reflex procedure was performed on the 2nd, 4th, 6th and 7th day. On the 9th day rats were treated with salidroside, sacrificed 1 h after ethanol injections and blood was collected for blood-ethanol concentration measurement.Results: Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to hypothermic and sedative effects of ethanol, whereas insignificant elevation of blood-ethanol concentration was observed. The dose of 4.5 mg/kgb.w.had minimal effect, only small inhibition of tolerance to hypothermic action was observed. Salidroside affected neither body mass growth nor body temperature in non-alcoholic (control) rats.Conclusions: Results of the study indicate that salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic effect of ethanol. Observed inhibition of tolerance to the sedative effect of ethanol seems to be associated with salidroside influence on the central nervous system. A comprehensive explanation of the abovementioned observations requires further pharmacological and pharmacodynamic studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Compounds 3 , 4 , and 12 are phenolics, which are shown to be anti-inflammatory, antioxidant, and neuroprotective [ 46 ]. The structures of 3 , 4 , 11 , and 12 have similar skeletal tyrosol bones, suggesting that the tyrosol skeleton may play a role in neuroprotective activity [ 47 , 48 ]. Compounds 6 and 11 are compounds that have a partial structure of gallic acid, which has good neuroprotective activity.…”

Section: Discussionmentioning

confidence: 99%

Protective Evaluation of Compounds Extracted from Root of Rhodiola rosea L. against Methylglyoxal-Induced Toxicity in a Neuronal Cell Line

et al. 2020

View full text Add to dashboard Cite

Rhodiola rosea L. (R. rosea) is one of the most beneficial medicinal plants and it is studied as an adaptogen. This study aims to evaluate the neuroprotective activity of compounds extracted from the root of R. rosea against methylglyoxal (MG)-induced apoptosis in neuro-2A (N2A) cells. The root of R. rosea was extracted with ethanol and partitioned with water, ethyl acetate, and n-butanol fractions to evaluate acetylcholinesterase (AChE) inhibitory activity and neuroprotective activity. The ethyl acetate fraction exhibited the highest values of AChE inhibitory activity (49.2% ± 3%) and cell viability (50.7% ± 4.8%) for neuroprotection. The structure identification of the most potential fraction (ethyl acetate fraction) revealed 15 compounds, consisting of three tannins, five flavonoids, and seven phenolics by infrared spectroscopy, nuclear magnetic resonance, and mass spectroscopy. All compounds were evaluated for their neuroprotective activity. Salidroside had the most potential neuroprotective activity. Gallic acid and methyl gallate had potential cytotoxicity in N2A cells. This study showed that R. rosea might have potential neuroprotective activities.

show abstract

“…Further research has shown that GlcNAc-Sal prevents brain I/R injury and suppresses mouse hippocampal HT22 cell apoptosis by reducing ROS generation, NO production, and the expression of caspase-3 [ 69 ]. In addition, the SAD metabolite p -tyrosol at a dose of 20 mg/kg also attenuates neuronal damage in the hippocampus as well as lipid peroxidation in brain tissue in animals subjected to global cerebral ischemia with reperfusion [ 70 ]. Taken together, SAD could prevent stroke and exert neuroprotective effects via multiple mechanisms.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Antioxidant Effects of Salidroside in the Cardiovascular System

Sun

Tuo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Cardiovascular disease is one of the main human health risks, and the incidence is increasing. Salidroside is an important bioactive component of Rhodiola rosea L., which is used to treat Alzheimer’s disease, tumor, depression, and other diseases. Recent studies have shown that salidroside has therapeutic effects, to some degree, in cardiovascular diseases via an antioxidative mechanism. However, evidence-based clinical data supporting the effectiveness of salidroside in the treatment of cardiovascular diseases are limited. In this review, we discuss the effects of salidroside on cardiovascular risk factors and cardiovascular diseases and highlight potential antioxidant therapeutic strategies.

show abstract

Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats

Cited by 26 publications

References 28 publications

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Protective Evaluation of Compounds Extracted from Root of Rhodiola rosea L. against Methylglyoxal-Induced Toxicity in a Neuronal Cell Line

Antioxidant Effects of Salidroside in the Cardiovascular System

Contact Info

Product

Resources

About