Ecological pressures and milk metabolic hormones of ethnic Tibetans living at different altitudes

Quinn, Elizabeth A.; Childs, Geoff

doi:10.3109/03014460.2016.1153144

Cited by 13 publications

(16 citation statements)

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“…[ 10 ], who reported higher total daily consumption of SML in a group of 3-month-old infants with higher weight gain compared with groups with low and normal weight gain. Other studies report inverse correlations of HM leptin with infant weight or BMI [ 19 , 36 , 42 , 60 , 62 , 63 , 64 ], no association [ 41 , 65 , 66 ], or positive associations [ 10 , 35 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…Further, some studies show a positive relationship between HM adiponectin and maternal adiposity [ 17 , 28 , 34 ], while others show no association [ 35 , 36 , 37 , 38 , 39 , 40 ]. Adiponectin initially was reported to associate negatively with infant growth and lean body mass accretion in earlier months postpartum [ 17 , 31 , 35 , 41 , 42 ], but recent findings of a few longitudinal studies also report positive associations emerging past 4–6 months of life [ 18 , 36 , 43 ]. These studies support the notion of differential age-related effects of adiponectin, which modulate growth in early development and promote a growth pattern thought to be responsible for the reduced or increased incidence of adult obesity.…”

Section: Introductionmentioning

confidence: 99%

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Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation

et al. 2018

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Human milk (HM) adipokines may influence infant feeding patterns, appetite regulation, and body composition (BC). The associations between concentrations/calculated daily intakes (CDI) of HM adipokines in the first 12 months postpartum and maternal/term infant BC, and infant breastfeeding parameters were investigated. BC of breastfeeding dyads (n = 20) was measured at 2, 5, 9, and/or 12 months postpartum with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers). 24-h milk intake and feeding frequency were measured along with whole milk adiponectin and skim and whole milk leptin (SML and WML) and CDI were calculated. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Adipokine concentrations did not associate with infant BC. Higher CDI of adiponectin were associated with lower infant fat-free mass (FFM; p = 0.005) and FFM index (FFMI; p = 0.009) and higher fat mass (FM; p < 0.001), FM index (FMI; p < 0.001), and %FM (p < 0.001). Higher CDI of SML were associated with higher infant FM (p < 0.001), FMI (p < 0.001), and %FM (p = 0.002). At 12 months, higher CDI of WML were associated with larger increases in infant adiposity (2–12 month: FM, p = 0.0006; %FM, p = 0.0004); higher CDI of SML were associated with a larger decrease in FFMI (5–12 months: p = 0.0004). Intakes of HM adipokines differentially influence development of infant BC in the first year of life, which is a critical window of infant programming and may potentially influence risk of later disease via modulation of BC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation

et al. 2018

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“…In both groups, the ratio of EGF to EGF-R decreased with age however LBWM consistently produced milk with lower EGF:EGF-R than ABWM Dominy, 2013;Quinn et al, 2015); we suggest that the higher levels of EGF found in the milk of Filipino women may be part of a larger pattern of milk differences between Western and non-Western women. There is a growing understanding that the level of hormones identified in the milk of Western women, especially those drawn from North America and Europe, may be higher or lower than those found in other populations (Quinn & Childs, 2017), especially for lean populations and those living outside of urban contexts. Comparative data on the ratio of EGF to EGF-R in human milk is largely unavailable, as very few studies have investigated EGF-R in human milk and consequently the ratio of EGF to EGF-R.…”

Section: F I G U R Ementioning

confidence: 99%

“…hypothesized to regulate infant weight gain and adiposity (Anderson et al, 2016;Fields & Demerath, 2012;Martin et al, 2006;Miralles, Sánchez, Palou, & Picó, 2006;Quinn & Childs, 2017;Savino, Liguori, Sorrenti, Fissore, & Oggero, 2011). Other bioactive molecules in human milk, such as growth factors, also likely regulate infant growth and development, although the strength of these associations is unknown (Donovan & Odle, 1994).…”

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confidence: 99%

Maternal birth weight is associated with milk epidermal growth factor in Filipino women

Kuziez

Harkey

Burack

et al. 2020

American J Hum Biol

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Objectives: Lactational programming, through which milk-borne bioactives influence both neonatal and long-term biological development, is well established. However, almost no research has investigated how developmental stimuli during a mother's early life may influence her milk bioactives in adulthood. Here, we investigated the association between maternal birth weight and milk epidermal growth factor (EGF) and epidermal growth factor receptor (EGF-R) in later life. We predicted there would be a decrease in both milk EGF and EGF-R in the milk produced by mothers who were themselves born low birth weight. Methods: Study participants are from the Cebu Longitudinal Health and Nutrition Survey. Mothers (n = 69) were followed longitudinally since birth with prospective data collection. Anthropometrics, health, and dietary recalls were collected with early morning milk samples when mothers were 24 to 25 years of age. Milk samples were analyzed for EGF and its receptor (EGF-R). Analysis of variance was used to test for differences in milk EGF and EGF-R between low and average birthweight mothers after adjustment for parity, age, and maternal dietary energy intake. Results: Mothers who were low birth weight produced milk with significantly less EGF and more EGF-R which resulted in a lower ratio of EGF to EGF-R. These associations persisted after adjustment for infant age, maternal adiposity, and dietary energy. Conclusions: While this is a small sample size, these preliminary findings suggest that maternal early life characteristics, such as birth weight, may be important contributors to variation in milk bioactives. Future work is necessary to understand how variation in maternal early life may influence milk composition in adulthood. 1 | INTRODUCTION The importance of human milk for infant growth and nutrition is well established. In addition to its role in nutrition, milk also contains numerous hormones, growth factors, and other bioactive molecules known to protect infant health and promote growth and development (Agostoni, 2005; Fields & Demerath, 2012). Among the best studied of these are the metabolic hormones, such as the adipokines leptin and adiponectin, which are

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“…Brown, 1990;Sangaramoorthy, 2020;Zuckerman, Harper, Barrett, & Armelagos, 2014). Anthropological studies of human milk provide clues to the breadth and depth of human biological diversity and adaptability (Hinde & Milligan, 2011;Klein et al, 2018;Miller 2018;Miller et al, 2013;Power & Schulkin, 2016;Quinn 2016;Quinn & Childs, 2017). Research is needed that more fully contextualizes lactation within the complexity of COVID-19 maternal-infant disease dynamics, in which human milk as part of a more holistic picture of diverse maternal-infant responses to infection (Table 1).…”

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confidence: 99%

The COVID‐19 liquid gold rush: Critical perspectives of human milk and SARS‐CoV‐2 infection

Palmquist

Asiodu

Quinn

2020

American J Hum Biol

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Ecological pressures and milk metabolic hormones of ethnic Tibetans living at different altitudes

Cited by 13 publications

References 71 publications

Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation

Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation

Maternal birth weight is associated with milk epidermal growth factor in Filipino women

The COVID‐19 liquid gold rush: Critical perspectives of human milk and SARS‐CoV‐2 infection

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