Prokineticin1 and pregnancy

Alfaidy, Nadia

doi:10.1016/j.ando.2016.04.014

Cited by 11 publications

(10 citation statements)

References 42 publications

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“…Recent studies from our own group and from others demonstrated that increased expression of EG-VEGF is associated with PE and FGR development (Hoffmann et al, 2006;Alfaidy, 2016;Inan et al, 2018). Our group also demonstrated that the concentration of EG-VEGF is significantly increased in both pathologies (Hoffmann et al, 2006;Murthi et al, 2015;Alfaidy, 2016). More recently, a study confirmed the increase in EG-VEGF levels in PE and proposed this factor as a biomarker for the diagnosis of PE patients (Inan et al, 2018).…”

Section: Prokineticins Expression In Micro-and Macrovascular Placentasupporting

confidence: 74%

“…Since its identification EG-VEGF has been associated with the control of placental angiogenesis during the first trimester of pregnancy and the reactivation of its receptors in the placenta of patients with pregnancy pathologies such as PE and FGR (Brouillet et al, 2010(Brouillet et al, , 2012a(Brouillet et al, , 2013a(Brouillet et al, , 2014aGarnier et al, 2015;Alfaidy, 2016;Sergent et al, 2016). The reactivation of angiogenic processes was meant to compensate for the associated deleterious vascularization.…”

Section: Key Regulators Of Prokineticins For Successful Placental Angmentioning

confidence: 99%

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The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

et al. 2020

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Section: Prokineticins Expression In Micro-and Macrovascular Placentasupporting

confidence: 74%

Section: Key Regulators Of Prokineticins For Successful Placental Angmentioning

confidence: 99%

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

et al. 2020

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“…In the formation of the capillary network in the placenta, one of the most important processes is angiogenesis, i.e., the process of new blood vessel formation from pre-existing blood vessels. Angiogenesis is tightly controlled by numerous angiogenic regulators, the most common of which are VEGFA, FGF2, ANGPT1, and ANGPT2 33 ; however, recent studies have shown an emerging role of PROK1 during pregnancy 7 – 9 , 12 . Our previous study has demonstrated that PROK1 is involved in endometrial angiogenesis by the stimulating endothelial cell proliferation and network formation and by increasing the secretion of VEGFA and PGF2α 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, in human trophoblast cells, PROKR1 mRNA expression has been found to be 80 times higher when compared to the expression of PROKR2 mRNA 11 . Besides angiogenesis, PROK1 may regulate a number of biological processes, including cell–cell contact, cell migration, proliferation, and inflammatory response 7 , 8 , 12 . Our recent study revealed that PROK1 could be an embryonic signal mediator which, acting via PROKR1, stimulates angiogenesis in the porcine endometrium during implantation and the early placentation period 7 .…”

Section: Introductionmentioning

confidence: 99%

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Prokineticin 1–prokineticin receptor 1 signaling in trophoblast promotes embryo implantation and placenta development

Goryszewska-Szczurek

Baryla

Kaczyński

et al. 2021

Sci Rep

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Successful pregnancy establishment in mammals depends on proper embryo-maternal communication. Prokineticin 1 (PROK1) is a secretory protein that exerts pleiotropic functions in various tissues. Despite the studies that have primarily been performed with human cell lines and mice, the function of PROK1 in trophoblasts has still not been fully elucidated. Hence, the aim of this study was to establish the role of PROK1 in trophoblasts during implantation and placentation. Prokineticin 1 mRNA was elevated in porcine trophoblasts during implantation and the early placentation period. Furthermore, we reveal that PROK1–PROKR1 signaling induces the expression of genes involved in the regulation of angiogenesis, immunological response, trophoblast cell adhesion, invasion, and proliferation, as well as stimulating phosphorylation of MAPK and PTK2. Ingenuity Pathway Analysis identified the aforementioned and also other functions associated with PROK1-regulated genes/proteins, such as cell-to-cell contact, epithelial tissue differentiation, Ca2+ release, lipid synthesis, and chemotaxis. We also showed evidence that PROK1 acting via PROKR1 increased trophoblast cell proliferation and adhesion. The PROK1-stimulated cell proliferation was mediated by PI3K/AKT/mTOR, MAPK, and cAMP, whereas adhesion was mediated by MAPK and/or PI3K/AKT signaling pathways. Concluding, our study suggests that PROK1 plays a pleiotropic role in trophoblast function during implantation and early placentation.

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Novel insights into conceptus–maternal signaling during pregnancy establishment in pigs

Kaczyński

Goryszewska-Szczurek

Baryla

et al. 2022

Molecular Reproduction Devel

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Pregnancy establishment in mammals, including pigs, requires coordinated communication between developing conceptuses (embryos with associated membranes) and the maternal organism. Porcine conceptuses signalize their presence by secreting multiple factors, of which estradiol‐17β (E2) is considered the major embryonic signal initiating the maternal recognition of pregnancy. During this time, a limited supply of prostaglandin (PGF2α) to the corpora lutea and an increased secretion of luteoprotective factors (e.g., E2 and prostaglandin E2 [PGE2]) lead to the corpus luteum's maintained function of secreting progesterone, which in turn primes the uterus for implantation. Further, embryo implantation is related to establishing an appropriate proinflammatory environment coordinated by the secretion of proinflammatory mediators including cytokines, growth factors, and lipid mediators of both endometrial and conceptus origin. The novel, dual role of PGF2α has been underlined. Recent studies involving high‐throughput technologies and sophisticated experimental models identified a number of novel factors and revealed complex relationships between these factors and those already established. Hence, it seems that early pregnancy should be regarded as a sequence of processes orchestrated by pleiotropic factors that are involved in redundancy and compensatory mechanisms that preserve the essential functions critical for implantation and placenta formation. Therefore, establishing the hierarchy between all molecules present at the embryo–maternal interface is now even more challenging

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Prokineticin1 and pregnancy

Cited by 11 publications

References 42 publications

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

Prokineticin 1–prokineticin receptor 1 signaling in trophoblast promotes embryo implantation and placenta development

Novel insights into conceptus–maternal signaling during pregnancy establishment in pigs

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