Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence

Lazaro, J. L.; Izzo, Valentina; Meaume, Sylvie; Davies, AH; Lobmann, Ralf; Uccioli, Luigi

doi:10.12968/jowc.2016.25.5.277

Cited by 150 publications

(110 citation statements)

References 62 publications

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“…Herewith we provide some examples for the multifunctional links strongly supported by independent studies, available data and literature sources: activities of metalloproteinases (in particular MMP-2 and MMP-9) and dysregulated enzymatic complexes MMPs/TIMPs are characteristic for both impaired wound healing and aggressive tumour promotion and metastatic disease [132,133] All the cascades listed above demand broad attention at the levels of fundamental research and complex healthcare approaches.…”

Section: Cancer and Impaired Wound Healing: Multi-faceted Interrelatimentioning

confidence: 96%

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Avishai¹,

2017

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Whereas the physiologic wound healing (WH) successfully proceeds through the clearly defined sequence of the individual phases of wound healing, chronic non-healing wounds/ulcers fail to complete the individual stages and the entire healing process. There are many risk factors both modifiable (such as stress, smoking, inappropriate alcohol consumption, malnutrition, obesity, diabetes, cardio-vascular disease, etc.) and non-modifiable (such as genetic diseases and ageing) strongly contributing to the impaired WH. Current statistics demonstrate that both categories are increasingly presented in the populations, which causes dramatic socio-economic burden to the healthcare sector and society at large. Consequently, innovative concepts by predictive, preventive and personalised medicine are crucial to be implemented in the area. Individual risk factors, causality, functional interrelationships, molecular signature, predictive diagnosis, and primary and secondary prevention are thoroughly analysed followed by the expert recommendations in this paper.

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Section: Cancer and Impaired Wound Healing: Multi-faceted Interrelatimentioning

confidence: 96%

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Avishai¹,

2017

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“…In the inflammatory phase, MMP-2 and MMP-9 act as chemical mediators on the stimulation steps in phagocytic phase. In granulation phase (proliferation), MMPs act along with other biomolecules with regulating activity in the formation of collagen and elastin matrix, reepithelialization, and vascularization [65].…”

Section: The Role Of Matrix Metalloproteinases (Mmps)mentioning

confidence: 99%

Low Level Energy Photodynamic Therapy for Skin Processes and Regeneration

Tedesco¹,

Jesus²

2017

Photomedicine - Advances in Clinical Practice

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Skin is the largest human organ and displays multiple functions involving structure and protection against external agents that may affect the body. Solar radiation accelerates the normal aging process and may even cause great damage leading to many different cutaneous diseases and skin cancer. Moreover, a wound in the skin may be an open channel for the access of pathogens usually exposing blood vessels for infections and causing serious complications. For many reasons, regulatory skin processes are of great deal in different approaches: basic antiaging, wound healing, and skin cancer. In a good way, photoprocesses with specific wavelength at low energy levels associated with photoactive compounds are known to cause the opposite effect, promoting the healing of cutaneous diseases and leading to well-defined outcomes in rejuvenation and antiaging. This chapter will discuss the most relevant topics in photo skin regeneration using low energy levels associated with photodynamic therapy (PDT), which emerged as a combination to potentialize molecules with the already known effects of PDT and low level laser therapy (LLLT) in the treatment of skin pathologies, known as a photobiomodulation process.

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“…Metalloproteinase concentration in a wound correlates with duration and chronification. 3 An effective intervention must thus modify this environment that impedes healing, and is essential to induce the reparative phase of healing and shorten the prior inflammatory phase. In order to succeed, chronic-ulcer management should have a dual approach, including both underlying disease and local wound treatment.…”

Section: Role Of Growth Factors In Wound Healingmentioning

confidence: 99%

Platelet-rich plasma for the treatment of chronic wounds: evidence to date

Conde-Montero¹,

Dobao²,

González³

2017

CWCMR

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Platelet-rich plasma (PRP) is a widely used throughout diverse fields of medicine for improving tissue regeneration. In dermatology, its main applications in the last few years have mainly been in antiaging treatment and wound healing. PRP contains platelets at higher concentrations than whole blood, and consequently represents a growth-factor pool. Chronic wounds are characterized by a prolonged inflammatory phase, involving a continuous destruction of matrix proteins and growth factors. Growth factors promote cell migration, proliferation, and differentiation, which are essential for wound healing. In this review, we explain the basic principles of PRP in wound healing and aim to offer an updated critical assessment of the available clinical evidence that supports the utility of PRP for the therapeutic challenge that chronic ulcers represent in our daily clinical practice.

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Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence

Abstract: The authors report no conflicts of interest in this work.

Cited by 150 publications

References 62 publications

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Low Level Energy Photodynamic Therapy for Skin Processes and Regeneration

Platelet-rich plasma for the treatment of chronic wounds: evidence to date

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