“…Most of these studies have been performed in prepubertal children, 29,31,[33][34][35][36] and some have included adolescents or young adults. 28,30,[37][38][39] Given the paucity of the data and the contrasting results, it is not clear whether puberty affects the GH response to CT and whether CT is a reliable GH-stimulating agent also in adolescents.…”