Histological identification of nasopharyngeal mechanoreceptors

Salburgo, Florent; García, Stéphane; Lagier, Aude; Esteve, D.; Lavieille, Jean‐Pierre; Montava, Marion

doi:10.1007/s00405-016-4069-3

Cited by 18 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the inside pressure of the middle ear needs to be precisely controlled. The isobaric system of the middle ear is thought to be composed of an afferent system transmitting the changes in the pressure gradient between the middle ear and the outside world, as well as an efferent system acting on key elements to restore the normal pressure when necessary ( Salburgo et al., 2016 ). The pressure difference between the environment and the middle ear (which happens in planes at the take-off and landing, for instance) can be sensed by tympanic membrane mechanoreceptors (Pacini corpuscules) which are sensitive to the stretching of this membrane ( Nagai & Tono, 1989 ) and lead to ear fullness.…”

Section: A Brief Overview Of the Middle Earmentioning

confidence: 99%

“…The pressure difference between the environment and the middle ear (which happens in planes at the take-off and landing, for instance) can be sensed by tympanic membrane mechanoreceptors (Pacini corpuscules) which are sensitive to the stretching of this membrane ( Nagai & Tono, 1989 ) and lead to ear fullness. Other mechanoreceptors (Ruffini corpuscules) have been found outside the middle ear, near the Eustachian tube exit, namely, on the nasopharynx ( Salburgo et al., 2016 ).…”

Section: A Brief Overview Of the Middle Earmentioning

confidence: 99%

See 1 more Smart Citation

An Integrative Model Accounting for the Symptom Cluster Triggered After an Acoustic Shock

et al. 2018

View full text Add to dashboard Cite

Acoustic shocks and traumas sometimes result in a cluster of debilitating symptoms, including tinnitus, hyperacusis, ear fullness and tension, dizziness, and pain in and outside the ear. The mechanisms underlying this large variety of symptoms remain elusive. In this article, we elaborate on the hypothesis that the tensor tympani muscle (TTM), the trigeminal nerve (TGN), and the trigeminal cervical complex (TCC) play a central role in generating these symptoms. We argue that TTM overuse (due to the acoustic shock), TTM overload (due to muscle tension), and ultimately, TTM injury (due to hypoxia and “energy crisis”) lead to inflammation, thereby activating the TGN, TCC, and cortex. The TCC is a crossroad structure integrating sensory inputs coming from the head–neck complex (including the middle ear) and projecting back to it. The multimodal integration of the TCC may then account for referred pain outside the ear when the middle ear is inflamed and activates the TGN. We believe that our model proposes a synthetic and explanatory framework to explain the phenomena occurring postacoustic shock and potentially also after other nonauditory causes. Indeed, due to the bidirectional properties of the TCC, musculoskeletal disorders in the region of the head–neck complex, including neck injury due to whiplash or temporomandibular disorders, may impact the middle ear, thereby leading to otic symptoms. This previously unavailable model type is experimentally testable and must be taken as a starting point for identifying the mechanisms responsible for this particular subtype of tinnitus and its associated symptoms.

show abstract

Section: A Brief Overview Of the Middle Earmentioning

confidence: 99%

Section: A Brief Overview Of the Middle Earmentioning

confidence: 99%

An Integrative Model Accounting for the Symptom Cluster Triggered After an Acoustic Shock

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In contrast to the baroreceptors found on the medial wall of the middle ear, the stretch receptors on the TM are not involved with pressure regulation: impulses resulting from TM vibrations provoke centrally mediated responses related to pharyngeal activity and perhaps TT contraction (80). The Ruffini corpuscles in the nasopharynx were not found on the tubal cartilage or inside the ET but in the PR fundus and posterior nasopharyngeal wall (39), which suggests a function related to the PR/ET complex rather than pressure regulation.…”

Section: Anatomical Arguments For the Existence Of A Feedback Systemmentioning

confidence: 83%

Tympanic Resonance Hypothesis

Boedts

2020

Front. Neurol.

View full text Add to dashboard Cite

Seemingly unrelated symptoms in the head and neck region are eliminated when a patch is applied on specific locations on the Tympanic Membrane. Clinically, two distinct patient populations can be distinguished; cervical and masticatory muscle tensions are involved, and mental moods of anxiety or need. Clinical observations lead to the hypothesis of a "Tympanic Resonance Regulating System." Its controller, the Trigeminocervical complex, integrates external auditory, somatosensory, and central impulses. It modulates auditory attention, and directs it toward unpredictable external or expected domestic and internal sounds: peripherally by shifting the resonance frequencies of the Tympanic Membrane; centrally by influencing the throughput of auditory information to the neural attention networks that toggle between scanning and focusing; and thus altering the perception of auditory information. The hypothesis leads to the assumption that the Trigeminocervical complex is composed of a dorsal component, and a ventral one which may overlap with the concept of "Trigeminovagal complex." "Tympanic Dissonance" results in a host of local and distant symptoms, most of which can be attributed to activation of the Trigeminocervical complex. Diagnostic and therapeutic measures for this "Tympanic Dissonance Syndrome" are suggested.

show abstract

“…The stratum corneum is the outermost layer of human skin; it exhibits a thickness of 10–15 µm [ 6 ] and serves as a barrier to the transepidermal delivery of many types of drugs. Microneedles can be painless if they do not interact with the unmyelinated nerve endings that detect pain or the mechanoreceptors that detect pressure in the dermis [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Micromolding of Amphotericin-B-Loaded Methoxyethylene–Maleic Anhydride Copolymer Microneedles

et al. 2022

View full text Add to dashboard Cite

Biocompatible and biodegradable materials have been used for fabricating polymeric microneedles to deliver therapeutic drug molecules through the skin. Microneedles have advantages over other drug delivery methods, such as low manufacturing cost, controlled drug release, and the reduction or absence of pain. The study examined the delivery of amphotericin B, an antifungal agent, using microneedles that were fabricated using a micromolding technique. The microneedle matrix was made from GantrezTM AN-119 BF, a benzene-free methyl vinyl ether/maleic anhydride copolymer. The GantrezTM AN-119 BF was mixed with water; after water evaporation, the polymer exhibited sufficient strength for microneedle fabrication. Molds cured at room temperature remained sharp and straight. SEM images showed straight and sharp needle tips; a confocal microscope was used to determine the height and tip diameter for the microneedles. Nanoindentation was used to obtain the hardness and Young’s modulus values of the polymer. Load–displacement testing was used to assess the failure force of the needles under compressive loading. These two mechanical tests confirmed the mechanical properties of the needles. In vitro studies validated the presence of amphotericin B in the needles and the antifungal properties of the needles. Amphotericin B GantrezTM microneedles fabricated in this study showed appropriate characteristics for clinical translation in terms of mechanical properties, sharpness, and antifungal properties.

show abstract

Histological identification of nasopharyngeal mechanoreceptors

Cited by 18 publications

References 19 publications

An Integrative Model Accounting for the Symptom Cluster Triggered After an Acoustic Shock

An Integrative Model Accounting for the Symptom Cluster Triggered After an Acoustic Shock

Tympanic Resonance Hypothesis

Micromolding of Amphotericin-B-Loaded Methoxyethylene–Maleic Anhydride Copolymer Microneedles

Contact Info

Product

Resources

About