Water response to ganglioside GM1 surface remodelling

Brocca, Paola; Rondelli, Valeria; Mallamace, Francesco; Bari, Maria Teresa Di; Deriu, A.; Lohstroh, Wiebke; Favero, Elena Del; Corti, Mario; Cantù, Laura

doi:10.1016/j.bbagen.2016.04.029

Cited by 3 publications

(2 citation statements)

References 41 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…over all samples in stage Ni, i = C, 0, 1, [2,3], 4, where Nc is for control samples; N [2,3] is the union of samples in N2 and N3, each of which tends to be too small, hence combined; and E(X) is the expression value of gene X in a sample under consideration. This problem is solved as a multi-classification and a regression problem using two separate neural networks, each with two-hidden layers, one for evaluating the performance of multi-classification model, and on this basis, the other for solving the Ci values and finding the F() function, respectively.…”

Section: A Sialic Acid-based Model For Cancer Metastasismentioning

confidence: 99%

“…It has been observed that increased syntheses of sialic acids (SAs) are associated with cancer development and metastasis since 1960's (1,2), where SAs are negatively charged nine-carbon sugars and generally serve as the capping molecules of cell-surface glycan, as part of plasma membrane-embedded gangliosides (3). Under physiological conditions, brain tissues have the highest concentration of SAs, used for synaptogenesis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elucidation of Functional Roles of Sialic Acids in Cancer Migration

et al. 2020

View full text Add to dashboard Cite

Sialic acids (SA), negatively charged nine-carbon sugars, have long been implicated in cancer metastasis since 1960's but its detailed functional roles remain elusive. We present a computational analysis of transcriptomic data of cancer vs. control tissues of eight types in TCGA, aiming to elucidate the possible reason for the increased production and utilization of SAs in cancer and their possible driving roles in cancer migration. Our analyses have revealed for all cancer types: (1) the synthesis and deployment enzymes of SAs are persistently up-regulated throughout the progression for all but one cancer type; and (2) gangliosides, of which SAs are part, tend to converge to specific types that allow SAs to pack at high densities on cancer cell surface as a cancer advances. Statistical and modeling analyses suggest that (i) a highly plausible reason for the increased syntheses of SAs is to produce net protons, used for neutralizing the OH − persistently generated by elevated intracellular iron metabolism coupled with chronic inflammation in cancer tissues; (ii) the level of SA accumulation on cancer cell surface strongly correlates with the stage of cancer migration, as well as multiple migration-related characteristics such as altered cell-cell adhesion, mechanical stress, cell protrusion, and contraction; and (iii) the pattern of SA deployment correlates with the 5-year survival rate of a cancer type. Overall, our study provides strong evidence for that the continuous accumulation of SAs on cancer cell surface gives rise to increasingly stronger cell-cell repulsion due to their negative charges, leading to cell deformation by electrostatic force-induced mechanical compression, which is known to be able to drive cancer cell migration established by recent studies.

show abstract

Section: A Sialic Acid-based Model For Cancer Metastasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elucidation of Functional Roles of Sialic Acids in Cancer Migration

et al. 2020

View full text Add to dashboard Cite

show abstract

Scattering Techniques and Ganglioside Aggregates: Laser Light, Neutron, and X-Ray Scattering

2018

View full text Add to dashboard Cite

Scattering techniques are applied to studying the structural features of ganglioside aggregates in solution. Here it is described how different probing radiations allow to access different structural and dynamical parameters on different lengthscales. Besides a brief but comprehensive description of the scattering measurements, several practical suggestions are given concerning the experiments and the data analysis.

show abstract