Benefits of Preventive Administration of<i>Chlorella</i>sp. on Visceral Pain and Cystitis Induced by a Single Administration of Cyclophosphamide in Female Wistar Rat

Hidalgo-Lucas, Sophie; Rozan, Pascale; Guérin‐Deremaux, Laetitia; Baert, Blandine; Violle, Nicolas; Saniez-Degrave, Marie-Hélène; Bisson, Jean‐François

doi:10.1089/jmf.2015.0077

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…The control rats received volume-matched saline i.p. The doses of the administered agents were chosen based on the literature data and were confirmed/adjusted in our laboratory in preliminary experiments (Hidalgo-Lucas et al 2016 ; Juszczak et al 2010 ; Kobayashi et al 2009 ; Wróbel and Rechberger 2015 ; Wróbel and Rechberger 2016a ; Wróbel and Rechberger 2016b ; Wróbel and Rechberger 2016c ).…”

Section: Methodsmentioning

confidence: 99%

Rho kinase inhibition ameliorates cyclophosphamide-induced cystitis in rats

Wróbel

Doboszewska

Rechberger

et al. 2017

Naunyn-Schmiedeberg's Arch Pharmacol

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Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors may suppress detrusor overactivity symptoms and possess anti-inflammatory properties. The aim of the present study was to investigate whether inhibition of ROCK reduces cystometric and histopathological changes associated with CYP-induced cystitis. The rats received GSK 269962, a ROCK inhibitor, at a dose of 30 mg/kg daily, or vehicle for 7 days. Then, acute chemical cystitis leading to bladder overactivity was induced by CYP injection (200 mg/kg i.p.). Following CYP injection, cystometric studies with physiological saline were performed. Moreover, bladder edema (by the Evans Blue dye leakage technique) and urothelium thickness were measured. CYP injection resulted in a significant increase in cystometric parameters: basal pressure, threshold pressure, bladder contraction duration, relaxation time, detrusor overactivity index, non-voiding contractions amplitude, and non-voiding contractions frequency as well as increased Evans Blue extravasation into bladder tissue, whereas micturition voiding pressure, voided volume, post-void residual, volume threshold, intercontraction interval, bladder compliance, and volume threshold to elicit non-voiding contractions as well as urothelium thickness were significantly decreased in CYP-injected rats. Administration of GSK 269962 normalized the abovementioned CYP injection-induced changes. Inhibition of ROCK was found to ameliorate CYP-induced detrusor overactivity and bladder inflammation. Our data indicate uroprotective effects following ROCK inhibition, which further suggests that this strategy may become an interesting pharmacological tool to prevent urinary adverse effects in patients treated with chemotherapy using CYP.

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Section: Methodsmentioning

confidence: 99%

Rho kinase inhibition ameliorates cyclophosphamide-induced cystitis in rats

Wróbel

Doboszewska

Rechberger

et al. 2017

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Indeed, various in vivo studies on CV have revealed that they exhibit antioxidative [ 40 ], hepatoprotective [ 41 ], antibacterial [ 16 ], and antitumor activity [ 42 ]. An increasing number of studies have demonstrated that CV and its extracts enhance the immune function in vitro and in vivo [ 43 , 44 , 45 ]. Furthermore, some researchers have focused on the immunomodulation of the protein hydrolysate from CV, and found that CV protein hydrolysate stimulated both humoral and cell mediated immune functions positively, such as T-dependent antibody response and the reconstitution of delayed-type hypersensitivity response [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Chlorella vulgaris Ameliorates Altered Immunomodulatory Functions in Cyclophosphamide-Induced Immunosuppressive Mice

et al. 2017

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Based on the well-known toxicity of cyclophosphamide (CYP) on the immune system, this research investigated the modulating effects of the long-term dietary Chlorella vulgaris (CV) supplementation on the immunosuppression induced by CYP in mice, in order to provide a novel dietary design to mitigate the side effects of CYP therapy. Control, CYP-treated, CYP + CV (6%), CYP + CV (12%) and CYP + CV (24%) were used for 6 weeks, CV supplement in diet recovered the significantly reduced immunological function in CYP treated mice. As CV may have a modulating function through the inducible expression of cytokines, we assayed the expressions of interleukin-2 (IL-2), interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Our results suggested that CYP significantly reduced the lymphocytes proliferation and phagocytic activities of macrophages, and stimulated the production of IL-2, IL-12, TNF-α and IFN-γ and that this impairment has been successfully adjusted by CV supplementation. Treatment with the algae also enhanced the natural killer (NK) cells cytotoxicity, and ameliorate histological changes of the spleen in CYP-treated mice. Therefore, as we found in this study, a diet supplemented with whole CV has beneficial effects on CVP-induced immunosuppression, through its immunomodulatory potential.

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“…The extracts were previously registered in Serbia as a di-karotene i vitamin A. Pored toga, hlorela se koristi kao proteinsko sredstvo za ljudsku upotrebu i kao alternativni antibiotik u stočarskoj proizvodnji. Potvrđeno je da hlorela takođe ima imunomodulatornu aktivnost kod pilića, poboljšavajući performanse rasta i kvalitet kokošijih jaja [35].…”

Section: Methodsunclassified

“…In addition, chlorella is used as a protein supplement for human consumption and as an alternative antibiotic in livestock production. Chlorella has also been confirmed to have immunomodulatory activity in chickens, improving growth performance and egg quality [35].…”

Section: Spirulina and Chlorellamentioning

confidence: 99%

Anamu, moringa, spirulina, and chlorella: Contribution to the quality of life of oncology patients: Results of the postmarketing prospective study performed in Serbia in 2021 - 2022

Estevez,

Kovčin,

Venegas

2023

Srpski medicinski časopis Lekarske komore

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Introduction: The quality of life is one of the priority goals in the treatment of oncology patients. In addition to conventional therapies, symptomatic and supportive treatments are valuable for the final treatment outcome. Many such patients resort to alternative methods, such as herbal therapy. Study aim: This prospective study aimed to assess the effect of the plants: anamu, moringa, spirulina, and chlorella, which are routinely used in Cuba, on the quality of life of oncology patients. Materials and methods: Forty-six patients with various stage four malignant tumors were examined. Of the 46 patients, 26 were on chemotherapy, while 18 were on symptomatic and supportive therapy. The patients used extracts of the aforementioned plants orally, for three months. With prior consent and authorization, the standard EORTC QLQ-C30 questionnaire, written in the patients' native language, was used to assess quality of life, before and after three months of use. Results: According to patient ratings, overall assessment of patient general health status and quality of life showed significant improvement after three months of use of the extracts, as compared to the beginning of application. According to the questionnaire, all five parameters improved on the functional scale, (p < 0.001), and the scores on the symptoms scale also improved (fatigue, p = 0.015; pain, p = 0 ,044). Women achieved better physical functionality and significant loss of fatigue and pain, while cognitive functionality improved in men. Emotional functionality improved in the subgroup of patients who were receiving chemotherapy, while in those who had previously received chemotherapy, there were significant differences in the symptoms scale score regarding loss of appetite and constipation - symptoms that resolved after three months of product use, thus equating the subgroups in terms of the reduction of these symptoms. In other functional parameters, statistically significant differences were also obtained for all patients. Conclusion: The improvement in the quality of life and functionality of patients, as well as the reduction in symptoms, whether the patients received chemotherapy or not, was statistically significant.

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Benefits of Preventive Administration ofChlorellasp. on Visceral Pain and Cystitis Induced by a Single Administration of Cyclophosphamide in Female Wistar Rat

Cited by 3 publications

References 35 publications

Rho kinase inhibition ameliorates cyclophosphamide-induced cystitis in rats

Rho kinase inhibition ameliorates cyclophosphamide-induced cystitis in rats

Dietary Chlorella vulgaris Ameliorates Altered Immunomodulatory Functions in Cyclophosphamide-Induced Immunosuppressive Mice

Anamu, moringa, spirulina, and chlorella: Contribution to the quality of life of oncology patients: Results of the postmarketing prospective study performed in Serbia in 2021 - 2022

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