Cerebral CTA with Low Tube Voltage and Low Contrast Material Volume for Detection of Intracranial Aneurysms

Niu, Qian; Chen, G.Z.; Schoepf, U. Joseph; Klitsie, M.A.J.; Cecco, Carlo N. De; Zhou, Chang Sheng; Luo, Song; Lu, Guang Ming; Zhang, Long Jiang

doi:10.3174/ajnr.a4803

Cited by 12 publications

(11 citation statements)

References 28 publications

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“…The maximum diameter ranged within 0.7‐3.0 mm, with the average as 1.85 ± 1.23 mm. The analysis based on the 3DRA “gold standard” targeting 13 standard parts (namely, 13 sites on each patient were investigated, and once a site was discovered as being IA, the other 12 sites were determined as negative) . In this study, except for the five aneurysms ≥3 mm, the total sample size was 13 × 59 – 5 = 762.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The analysis based on the 3DRA "gold standard" targeting 13 standard parts (namely, 13 sites on each patient were investigated, and once a site was discovered as being IA, the other 12 sites were determined as negative). 20,21 In this study, except for the five aneurysms 3 mm, the total sample size was 13 3 59 -5 5 762. It was revealed that the sensitivity, specificity, and accuracy of L-CTA in diagnosing IMA were 93.85% (61/65), 99.56% (694/ 697), and 99.08% (755/762), respectively.…”

Section: Comparison Of L-cta With 3dra In Diagnosing Imamentioning

confidence: 98%

“…The system automatically calculated the radiation dose estimates CTDIvol (mGy) and dose length product (DLP, mGy cm) according to the scanning parameters; effective dose (ED) (mSv) was then calculated based on DLP, i.e., ED 5 k 3 DLP, where k was the tissue weighting factor (mSv 3 mGy 21 3 cm 21 ); k was set as 0.0021, the adult head weighting factor recommended by the European Commission. 20 2.6 | Statistical processing SPSS20.0 was used, and 3DRA was set as the "gold standard" to calculate the diagnostic sensitivity, specificity, and accuracy of L-CTA in identifying IMA. The comparison of 3D-DSA results of the aneurysm's maximum diameter and neck were made with linear correlation analysis.…”

Section: Radiation Dose Of Ctmentioning

confidence: 99%

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Control study of low tube voltage computed tomography angiography (CTA) and digital subtraction angiography (DSA) in diagnosing intracranial micro‐aneurysm

Duan

Liu

et al. 2017

Int J Imaging Syst Tech

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The aim of this study was to investigate the diagnostic values of low tube voltage cerebral computed tomography (CT) angiography (L‐CTA, 100 kV) of intracranial micro‐aneurysms (IMA, maximum diameter ≤3 mm). The clinical and imaging data of a total of 59 IMA patients confirmed by 3D rotational angiography (3DRA) or surgery were retrospectively analyzed; their L‐CTA data were compared with those of IMA and 3DRA so as to investigate the diagnostic sensitivity, specificity, and accuracy of IMA, as well as to objectively evaluate the related radiation dose. Based on the results of 3DRA, 65 cases of IMA and a total of 70 aneurysms, including 65 micro‐aneurysms, were found in the 59 cases. L‐CTA detected a total of 64 IMA, including six multiple cases of IMA, as well as three false positive cases and four missed cases. Compared with the 3DRA (gold standard), the diagnostic sensitivity, specificity, and accuracy of L‐CTA toward IMA were 93.85%, 99.56%, and 99.08%, respectively, and the associations of aneurysm size measured by L‐CTA and 3DRA were good. Compared with conventional CTA, the effective dose of L‐CTA was reduced by 36.23%. L‐CTA has high diagnostic sensitivity toward IMA, and can effectively reduce the radiation dose, so it is worth implementing.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Comparison Of L-cta With 3dra In Diagnosing Imamentioning

confidence: 98%

Section: Radiation Dose Of Ctmentioning

confidence: 99%

See 2 more Smart Citations

Control study of low tube voltage computed tomography angiography (CTA) and digital subtraction angiography (DSA) in diagnosing intracranial micro‐aneurysm

Duan

Liu

et al. 2017

Int J Imaging Syst Tech

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“… 7 , 8 , 9 , 10 Although digital subtraction angiography (DSA) is still the gold standard for diagnosing IAs, CTA has been proved to be able to diagnose IAs in most situations 11 , 12 , 13 , 14 and is a non-invasive, time-saving, and cost-effective technique with usually wider availability. 15 Besides, compared with MRA, CTA is a faster, widely available diagnostic technique that costs less and has higher image resolution.…”

Section: Introductionmentioning

confidence: 99%

Toward human intervention-free clinical diagnosis of intracranial aneurysm via deep neural network

Qiao

Tian

et al. 2021

Patterns

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Summary Intracranial aneurysm (IA) is an enormous threat to human health, which often results in nontraumatic subarachnoid hemorrhage or dismal prognosis. Diagnosing IAs on commonly used computed tomographic angiography (CTA) examinations remains laborious and time consuming, leading to error-prone results in clinical practice, especially for small targets. In this study, we propose a fully automatic deep-learning model for IA segmentation that can be applied to CTA images. Our model, called Global Localization-based IA Network (GLIA-Net), can incorporate the global localization prior and generates the fine-grain three-dimensional segmentation. GLIA-Net is trained and evaluated on a big internal dataset (1,338 scans from six institutions) and two external datasets. Evaluations show that our model exhibits good tolerance to different settings and achieves superior performance to other models. A clinical experiment further demonstrates the clinical utility of our technique, which helps radiologists in the diagnosis of IAs.

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Computed Tomography of the Head

et al. 2023

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In 1971, the first computed tomography (CT) scan was performed on a patient’s brain. Clinical CT systems were introduced in 1974 and dedicated to head imaging only. New technological developments, broader availability, and the clinical success of CT led to a steady growth in examination numbers. Most frequent indications for non-contrast CT (NCCT) of the head include the assessment of ischemia and stroke, intracranial hemorrhage and trauma, while CT angiography (CTA) has become the standard for first-line cerebrovascular evaluation; however, resulting improvements in patient management and clinical outcomes come at the cost of radiation exposure, increasing the risk for secondary morbidity. Therefore, radiation dose optimization should always be part of technical advancements in CT imaging but how can the dose be optimized? What dose reduction can be achieved without compromising diagnostic value, and what is the potential of the upcoming technologies artificial intelligence and photon counting CT? In this article, we look for answers to these questions by reviewing dose reduction techniques with respect to the major clinical indications of NCCT and CTA of the head, including a brief perspective on what to expect from current and future developments in CT technology with respect to radiation dose optimization.

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Cerebral CTA with Low Tube Voltage and Low Contrast Material Volume for Detection of Intracranial Aneurysms

Cited by 12 publications

References 28 publications

Control study of low tube voltage computed tomography angiography (CTA) and digital subtraction angiography (DSA) in diagnosing intracranial micro‐aneurysm

Control study of low tube voltage computed tomography angiography (CTA) and digital subtraction angiography (DSA) in diagnosing intracranial micro‐aneurysm

Toward human intervention-free clinical diagnosis of intracranial aneurysm via deep neural network

Computed Tomography of the Head

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