Simultaneous detection of antibiotics and other drug residues in the dissolved and particulate phases of water by an off-line SPE combined with on-line SPE-LC-MS/MS: Method development and application

Tlili, Imen; Caria, Giovanni; Ouddane, Baghdad; Ghorbel–Abid, Ibtissem; Ternane, Riadh; Trabelsi‐Ayadi, Malika; Net, Sopheak

doi:10.1016/j.scitotenv.2016.04.101

Cited by 61 publications

(20 citation statements)

References 43 publications

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“…Off-line extraction combined with on-line SPE and LC/MS/MS by Tlili et al (2016) was used for determination of antibiotics and other drugs in water and suspended solids from French wastewater treatment plant (WWTP) influent and effluent, aerated lagoons, and river waters. Pressurized liquid extraction (PLE) protocols were optimized for three residue classes before combining for the final extracts.…”

Section: Methodsmentioning

confidence: 99%

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Snow¹,

Cassada²,

Larsen³

et al. 2017

Water Environment Research

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A total of 79 papers published in 2016 were reviewed ranging from detailed descriptions of analytical methods, to fate and occurrence studies, to ecological effects and sampling techniques for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, steroids, antibiotic resistance genes, cyanotoxins, and potential effects of biochar use in agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Steroid Hormones, Anthelmintics, Antibiotic Fate and Occurrence, Antibiotic Resistance Genes, Cyanotoxins, and Implications of Biochar in Agricultural Environments.

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Section: Methodsmentioning

confidence: 99%

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Snow¹,

Cassada²,

Larsen³

et al. 2017

Water Environment Research

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“…Hormones and antibiotics are widely utilized as part of the rapid development of agriculture and animal husbandry. The incomplete adsorption of the two substances in the living body makes them excreted in the form of derived products or original structures [1][2][3][4][5][6]. These excrements can bring severe pollution in soil when used as manures, which will further have an effect on human health [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Response Surface Optimization of an Extraction Method for the Simultaneous Detection of Sulfamethoxazole and 17β-Estradiol in Soil

et al. 2020

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Antibiotics and hormones widely exist in fertilizers and manures, which are excessively used in agriculture and animal husbandry. Considering their potential harm to the environment and human health, the detection of antibiotics and hormones has become a necessity. However, current methods find it difficult to simultaneously extract and detect antibiotics and hormones in soil and to maintain a high level of accuracy and a low cost. In this study, a straightforward, convenient, and simultaneous extraction and detection method of a representative antibiotic (sulfamethoxazole, SMZ) and hormone (17β-Estradiol, E2) in soil has been established. Ultrasound-assisted extraction (UAE) was used in the pretreatment process and high-performance liquid chromatography with the ultraviolet detector (HPLC-UV) method was then chosen in the detection process. By means of single factors and response surface experiments, optimal extraction conditions were a 41-mL buffer solution (pH 4.27) mixed with 1 g of soil sample, an ultrasonication time of 36 min, an ultrasonication temperature of 25 °C, and two extraction cycles. The detection limits of 0.3–10 μg/kg and quantification limits of 1–30 μg/kg have been obtained. Finally, the optimized simultaneous extraction and detection method was validated by three different real soil samples with recoveries ranging from 79.49% to 86.47%.

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“…These compounds are typically persistent in the Article Related Abbreviations: APS, ammonium persulfate; CM-PPy, cellulose membrane modified with polypyrrole; EC, emerging contaminant; PPy, polypyrrole environment and may be prone to bioaccumulation in organisms in the trophic chain [4]. This can lead to adverse effects on exposed organisms even at very low concentrations (μg/L and ng/L), for instance, the feminization of fish [5] and amphibians [6], inhibition of the growth of human embryonic cells [7], and antibiotic resistance [8,9]. Wastewater effluent is a major source of ECs in the environment, in addition to surface and agricultural run-off.…”

Section: Introductionmentioning

confidence: 99%

Cellulose membrane modified with polypyrrole as an extraction device for the determination of emerging contaminants in river water with gas chromatography–mass spectrometry

Noronha

Bergamini

Marcolino‐Júnior

et al. 2018

J of Separation Science

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In this study, a simple, efficient, and reusable device based on cellulose membranes modified with polypyrrole was developed to extract 14 emerging contaminants from aqueous matrices. For chemical polymerization, a low-cost cellulose membrane was immersed in 0.1 mol/L pyrrole and 0.5 mol/L ammonium persulfate for 40 min in an ice/water bath. The cellulose membranes modified with polypyrrole were accommodated in a polycarbonate holder suitable for solid-phase extraction disks. Solid-phase extraction parameters that affect extraction efficiency, such as sample volume, pH, flow rate, and desorption were optimized. Subsequently, determination of target compounds was performed by gas chromatography with mass spectrometry. The linear range for analytes ranged from 0.05 to 500 μg/L, with coefficients of determination above 0.990. The limits of quantification varied between 0.05 and 10 μg/L, with relative standard deviations lower than 17%. The performance of the proposed cellulose membranes modified with polypyrrole device for real samples was evaluated after extraction of emerging contaminants from a river water sample from the city of Curitiba, Brazil. Bisphenol A (6.39 μg/L), caffeine (17.83 μg/L), and paracetamol (19.28 μg/L) were found in these samples.

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Simultaneous detection of antibiotics and other drug residues in the dissolved and particulate phases of water by an off-line SPE combined with on-line SPE-LC-MS/MS: Method development and application

Cited by 61 publications

References 43 publications

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Response Surface Optimization of an Extraction Method for the Simultaneous Detection of Sulfamethoxazole and 17β-Estradiol in Soil

Cellulose membrane modified with polypyrrole as an extraction device for the determination of emerging contaminants in river water with gas chromatography–mass spectrometry

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