Tumor suppressive actions of the nuclear receptor corepressor 1

Martínez-Iglesias, Olaia; Alonso-Merino, Elvira; Aranda, Ana

doi:10.1016/j.phrs.2016.04.027

Cited by 8 publications

(9 citation statements)

References 64 publications

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“…The function of these enzymes depends, in many occasions, on the presence of co-repressors, which can facilitate or repress the transcription of several genes [4]. The Nuclear Receptor Corepressor 1 (NCOR1) is one of those co-repressors that regulates the transcription by facilitating the recruitment of HDAC1, 2, 3, 4, 5 and 7 [5]. Among all, HDAC3 is probably the principal responsible of its activity, as the catalytic activity of this enzyme requires interaction with NCOR [3, 6].…”

Section: Introductionmentioning

confidence: 99%

“…NCOR1 plays a central role in human biology, being involved in many process including lipid metabolisms, cell fate, glucose homeostasis or neural stem cells [5]. Indeed, germline mutations of NCOR produce embryonic lethality [7].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, germline mutations of NCOR produce embryonic lethality [7]. NCOR1 has also been involved in cancer [5, 8, 9]. Mutations or deletions of this gene have been described in several solid tumors, such as colorectal cancer, bladder cancer or hepatocarcinomas [5, 8, 9].…”

Section: Introductionmentioning

confidence: 99%

“…NCOR1 has also been involved in cancer [5, 8, 9]. Mutations or deletions of this gene have been described in several solid tumors, such as colorectal cancer, bladder cancer or hepatocarcinomas [5, 8, 9]. Indeed, it has been considered as a tumor suppressor gene as reduced levels of the gene promote tumor proliferation and invasion [5].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene

et al. 2018

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Regulation of transcription is a key process in cellular homeostasis. It depends on regulators that either repress or stimulate the transcription of genes, therefore controlling different biological functions. The Nuclear Receptor Corepressor 1 (NCOR1) is one of those co-repressors that regulate the transcription by facilitating the recruitment of HDAC1, 2, 3, 4, 5 and 7. In our article, by using an in silico approach, we evaluate the mutational status of NCOR1 in breast and lung tumors. We identified that NORC1 is mutated in more than 3% of breast tumors and lung adenocarcinomas and linked this fact with detrimental outcome in some subtypes, particularly in those that are hormone receptor negative. In addition to these findings, as mutations in this gene are deleterious, we confirmed that high levels of this gene were linked with good prognosis in the same tumor subtypes. Findings in the same direction were identified in lung adenocarcinomas, with mutations associated with detrimental prognosis and high expression with better outcome. In conclusion, hereby we describe the presence and prognostic role of mutations in the NCOR1 gene in hormone receptor negative breast and lung adenocarcinomas, and we also confirm that NCOR1 is a tumor suppressor gene. Further studies should be performed to explore therapeutic mechanisms to restore its function.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene

et al. 2018

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“…TRβ increases NCoR levels, thus suppressing the transcription of prometastatic genes, whereas decreased NCoR leads to increased tumor growth, invasion and metastasis, suggesting that NCoR is a critical mediator of the suppressive actions of TRβ in tumor growth and metastasis (Martinez-Iglesias et al 2016a).…”

Section: Pi3k/protein Kinase B Pathwaymentioning

confidence: 99%

Role of thyroid hormones in the neoplastic process: an overview

Goemann¹,

Romitti²,

Meyer³

et al. 2017

Endocrine-Related Cancer

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Thyroid hormones (TH) are critical regulators of several physiological processes, which include development, differentiation and growth in virtually all tissues. In past decades, several studies have shown that changes in TH levels caused by thyroid dysfunction, disruption of deiodinases and/or thyroid hormone receptor (TR) expression in tumor cells, influence cell proliferation, differentiation, survival and invasion in a variety of neoplasms in a cell type-specific manner. The function of THs and TRs in neoplastic cell proliferation involves complex mechanisms that seem to be cell specific, exerting effects via genomic and nongenomic pathways, repressing or stimulating transcription factors, influencing angiogenesis and promoting invasiveness. Taken together, these observations indicate an important role of TH status in the pathogenesis and/or development of human neoplasia. Here, we aim to present an updated and comprehensive picture of the accumulated knowledge and the current understanding of the potential role of TH status on the different hallmarks of the neoplastic process.

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