Bone turnover alterations across the menopausal transition in south-eastern Chinese women

Ma, Linjuan; Song, Yang; Li, C; Wang, E; Zheng, Dan; Qu, Fan; Zhou, Jianyu

doi:10.1080/13697137.2016.1180677

Cited by 9 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This hypothesis is supported by both our results and previous studies [9,29] . As the major hormonal regulator of bone metabolism in both genders [30] , estrogen helps maintain bone homeostasis, and BTMs are elevated in postmenopausal women due to estrogen deficiency [31,32] . Considering the decreased estrogen levels in postmenopausal women and the possible effect of androgen in males, the association of BTMs with T2DM, insulin sensitivity and beta cell function differed to some extent between the genders.…”

Section: Discussionmentioning

confidence: 99%

Association of bone turnover markers with glucose metabolism in Chinese population

et al. 2017

View full text Add to dashboard Cite

The association between type 2 diabetes (T2DM) and bone metabolism has been discussed previously but is controversial. In this study we aimed to evaluate the association of bone turnover markers with glucose metabolism in Chinese population, in which 919 males and 4171 postmenopausal females in a region of Shanghai were recruited. Anthropometric and biochemical traits related to glucose and bone metabolism were analyzed. Participants were classified according to their glucose tolerance as normal glucose tolerance (NGT), impaired glucose regulation (IGR) or T2DM. Males and females were analyzed separately, and then associations between bone turnover markers (BTMs) and glucose metabolism were evaluated. The results showed that in females, the serum levels of N-terminal osteocalcin (N-MID), N-terminal procollagen of type I collagen (PINP) and β-cross-linked C-telopeptide of type I collagen (β-CTX) were significantly decreased in the T2DM group compared to the NGT group (P<0.01). When age, body mass index, serum lipids, fat percentage, visceral fat area, subcutaneous fat area, anti-diabetic medicines, PINP, N-MID and β-CTX were included in one logistic model, N-MID (OR [95% CI]: 0.954 [0.932; 0.976]; P=0.0001) was significantly associated with T2DM in females. In females, N-MID was associated with insulin sensitivity and HOMA-β. PINP was significantly associated with HOMA-β, GUTT-ISI, Stumvoll first-phase insulin secretion index (STU-1) and Stumvoll second-phase insulin secretion index (STU-2), but β-CTX was associated only with HOMA-β (β±SE: 0.1331±0.0311; P=1.95×10) and GUTT-ISI (β±SE: 0.0727±0.0229; P=0.0015). In males, N-MID was significantly correlated with HOMA-β (β±SE: 0.3439±0.0633; P=7.75×10), GUTT-ISI (β±SE: 0.1601±0.0531; P=0.0027) and STU-1 (β±SE: 0.2529±0.1033; P=0.0146). Significant associations were also detected between β-CTX and HOMA-β (β±SE: 0.2736±0.0812; P=0.0009). This study reveals that BTMs are highly associated with T2DM, insulin sensitivity and beta cell function in both Chinese males and postmenopausal females.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of bone turnover markers with glucose metabolism in Chinese population

et al. 2017

View full text Add to dashboard Cite

show abstract

“…reported that in postmenopausal women, elevated levels of LH induced changes in adrenal function towards cortisol secretion, which may contribute to an increased incidence of metabolic syndrome in women after menopause. In addition, it has been revealed that elevated serum FSH levels are independent risk factors for bone loss in postmenopausal women and could be used as indicators in the early diagnosis of postmenopausal osteoporosis42.…”

Section: Discussionmentioning

confidence: 99%

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Chen

Wang

Zhai

et al. 2016

Sci Rep

View full text Add to dashboard Cite

We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin(SHBG) levels were measured. The results showed that median values (interquartile range) of BLLs were 44.00 μg/L (29.00–62.30) for men and 41.00 μg/L (27.00–59.81) for postmenopausal women. In linear regression, after adjusting for age, current smoking status, body mass index, systolic blood pressure, diabetes and blood cadmium level, TT (P for trend = 0.001) and SHBG (P for trend < 0.001) levels were still positively associated with BLLs in men. Meanwhile, significant positive associations were found for BLLs with SHBG (P for trend = 0.002), FSH (P for trend = 0.001) and LH (P for trend = 0.026) levels in postmenopausal women. Additionally, the association between BLL and SHBG was modified by dysglycaemia (P for interaction = 0.03) in postmenopausal women. In conclusion, BLLs were associated with reproductive hormone levels in the general population of Chinese men and postmenopausal women, which may have important implications for human health. Concerted efforts to reduce adult lead exposure are warranted.

show abstract

“…Moreover, FSHR knockdown with specific siRNA in mice demonstrated lower LDLR (103), suggesting that FSH may be indirectly involved in the pathogenesis of NAFLD. Finally, in a Chinese cohort, rising FSH levels correlated positively with serum cholesterol and LDL levels in postmenopausal women (104).…”

Section: Introductionmentioning

confidence: 98%

FSH Beyond Fertility

et al. 2019

View full text Add to dashboard Cite

The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.

show abstract

Bone turnover alterations across the menopausal transition in south-eastern Chinese women

Abstract: The elevated serum levels of FSH were independent risk factors for bone loss in peri- and postmenopausal women, and measurement of the serum FSH levels in mid-age women with irregular menses could be used in early diagnosis of postmenopausal osteoporosis.

Cited by 9 publications

References 31 publications

Association of bone turnover markers with glucose metabolism in Chinese population

Association of bone turnover markers with glucose metabolism in Chinese population

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

FSH Beyond Fertility

Contact Info

Product

Resources

About