Sleep-disordered breathing in children with asthma: a systematic review on the impact of treatment

Sánchez, Trinidad; Castro-Rodriguez, José; Brockmann, Pablo E.

doi:10.2147/jaa.s85624

Cited by 39 publications

(18 citation statements)

References 56 publications

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“…The link among asthma and sleep-related breathing disorder (SRBD) is bidirectional due to common risk contributors that, finally, induce airway inflammation ( 7 , 8 ). SRBD in children with asthma may lead to difficult-to-control asthma.…”

Section: Introductionmentioning

confidence: 99%

Association of Asthma and Allergic Rhinitis With Sleep-Disordered Breathing in Childhood

et al. 2018

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Objective: Asthma and allergic rhinitis (AR) are the most common chronic conditions in childhood and have previously been linked to sleep-related breathing disorder (SRBD). Aim of the study was to examine the association between SRBD risk and asthma control in children with asthma and with or without AR.Methods: The assessment of FeNO and pulmonary function tests were performed in 140 children (65 with asthma, 57 with both asthma, and AR, 18 with only AR). Children with asthma completed the childhood Asthma Control Test (c-ACT), and the Sleep-Related Breathing Disorder scale, extracted from the Pediatric Sleep Questionnaire (PSQ). C-ACT scores ≤ 19 are indicative of poor asthma control whereas SRBD from PSQ scores ≥ 0.33 are suggestive of high risk for SRBD.Results: Mean age ± SD was 7.8 ± 3.1 years. Mean PSQ ± SD and c-ACT ± SD scores were 0.17 ± 0.14 and 24.9 ± 3.2, respectively. High risk for SRBD was identified in 26 children. Children at high risk for SRBD had significantly decreased c-ACT score (P = 0.048), verified by a negative association between c-ACT and PSQ-SRBD scores (r = −0.356, P < 0.001). Additionally a difference in diagnosis distribution between children at high or low risk for SRBD was observed. More specifically, among children at high risk, 88.5% were diagnosed with both atopic conditions, while this percentage among children at low risk was 29.8%. Asthma was mainly diagnosed in the latter group (P < 0.001).Conclusions: Poor asthma control is associated with SRBD. The presence of AR in children with asthma seems to increase the prevalence of SRBD in that particular population, requiring further investigation toward this direction.

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Section: Introductionmentioning

confidence: 99%

Association of Asthma and Allergic Rhinitis With Sleep-Disordered Breathing in Childhood

et al. 2018

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“… 5 , 6 However, until now, the prevalence of OSA in patients with asthma, especially in children with asthma, has not been clearly demonstrated. In a recent systematic review, Sánchez et al 7 showed that children with asthma had a significant and higher risk of OSA than subjects without OSA and that both diseases shared some similar symptoms (overlap) during sleep, making the diagnosis of each more difficult.…”

Section: Introductionmentioning

confidence: 99%

Study of the clinical and functional characteristics of asthmatic children with obstructive sleep apnea

Nguyen-Hoang¹,

Nguyen-Thi-Dieu²,

Duong‐Quy³

2017

JAA

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Background and objectiveThe obstructive sleep apnea (OSA) is a common respiratory disorder in children, especially those at preschool and school ages. This study aimed to describe the characteristics of asthmatic children with OSA and the symptoms for a high risk of OSA.Subjects and methodsIt was a prospective and descriptive study. The data of asthmatic children including medical history, clinical examination, blood tests, spirometry, exhaled nitric oxide (NO), and respiratory polygraphy were registered for analyses.ResultsEighty-five asthmatic children with a mean age of 9.5 ± 2.1 years were included. The prevalence of OSA was 65.9% (56/85) in study subjects. The prevalence of severe OSA in children with moderate asthma was significantly higher than intermittent and mild asthma. The percentage of asthmatic children with OSA who had snoring, sleep disturbance, and nocturnal sweats was significantly higher than that of asthmatic children without OSA (48.2% vs 17.2%, 71.4% vs 27.5%, and 55.1% vs 31.0%, respectively). The presence of allergic rhinitis and snoring was associated significantly with a high probability for the presence of OSA.ConclusionChildren with asthma have a risk of OSA. Asthmatic children with suggested symptoms such as snoring or waking up at night should be screened for OSA.

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“…A bidirectional relationship appears to exist between various health concerns and sleep quality. 1,11,12,27,28 A strong correlation between hypertension, cardiovascular disease, and stroke compared with the quality and quantity of sleep has been consistently shown in literature. 29 Children who have undiagnosed and untreated sleep disruptions and/or sleep disorders are also at increased risk for hypertension.…”

Section: Systemic Health Concerns Related To Poor Sleepmentioning

confidence: 83%

“…34 Sleep-disordered breathing and asthma have been correlated, as both are inflammatory disorders of the upper and lower airways and can contribute to respective worsening of each condition and possibly lead to OSA. 27 To make matters more complicated, many of the medications used to treat sleep-related medical conditions contribute to poor sleep due to the type of receptor antagonist effect in the brain. 2 According to the National Sleep Foundation, medications taken to treat nasal congestion, hypertension, heart disease, thyroid disorders, birth control, breathing issues, and cognitive health concerns can contribute to difficulty with falling and/or staying asleep.…”

Section: Systemic Health Concerns Related To Poor Sleepmentioning

confidence: 99%

“…16,25 Research suggests oral structure formation and health concerns can put men, women, and children at risk for a poor sleep situation that needs to be identified and addressed. 5,6,11,16,26,27 This paper will assist the oral health professional in recognizing the relationship between sleep and health, identifying sleep quality concerns in relation to oral health assessments, disseminating sleep quality assessments, and determining appropriate referrals for sleep quality issues.…”

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confidence: 99%

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Recognizing Poor Sleep Quality Factors During Oral Health Evaluations

Schroeder

Gurenlian

2019

Clin Med Res

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Oral health practitioners routinely perform oral health assessments for the dental patient to determine if oral disease is present. Systemic health is often a contributor to oral health concerns. One area in particular that has a direct effect on oral structures and oral health is poor sleep quality and open mouth breathing. Sleep is a fundamental process of the human body, which regulates core biological functions. Sleep quality reflects a person's ability to fall asleep, stay asleep, and enter into the various rejuvenating sleep cycles for the full duration. A person who does not obtain quality sleep can exhibit a wide range of oral, systemic, and cognitive health problems. Obstructive sleep apnea, which historically has been considered an adult male disease, is being recognized more often in women children. Research suggests various oral malformations found in newborns and young children can manifest as obstructive sleep apnea in adults. Oral health professionals are in a position to recognize the relationship between sleep and health, identify sleep quality concerns in relation to oral health assessments, administer sleep quality assessments, and determine appropriate referrals for further sleep quality evaluation.

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Sleep-disordered breathing in children with asthma: a systematic review on the impact of treatment

Cited by 39 publications

References 56 publications

Association of Asthma and Allergic Rhinitis With Sleep-Disordered Breathing in Childhood

Association of Asthma and Allergic Rhinitis With Sleep-Disordered Breathing in Childhood

Study of the clinical and functional characteristics of asthmatic children with obstructive sleep apnea

Recognizing Poor Sleep Quality Factors During Oral Health Evaluations

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