Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations

Jacobs, Elizabeth T.; Haussler, Mark R.; Alberts, David S.; Kohler, Lindsay N.; Lance, Peter; Martı́nez, Marı́a Elena; Roe, Denise J.; Jurutka, Peter W.

doi:10.1158/1940-6207.capr-16-0033

Cited by 9 publications

(6 citation statements)

References 43 publications

(58 reference statements)

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“…The ligation of vitamin D with its cytosolic receptor results in increased protein synthesis as well as phosphorylation of intracellular proteins enhancing the kinetics of smooth muscle contraction [31][32][33]. In addition, activated vitamin D receptors in mice and humans increase hepatic expression of CYP3A4, a cytochrome P450 enzyme that decreases bile acid hydrophobicity, and thus toxicity, of bile acids [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele

et al. 2020

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Gallbladder mucocele (GBM) is a common biliary disorder in dogs. Gallbladder hypokinesia has been proposed to contribute to its formation and progression. The specific cause of gallbladder stasis in dogs with GBM as well as viable treatment options to resolve dysmotility remains unknown. Vitamin D deficiency is one of the many potential causes of gallbladder hypokinesia in humans and repletion results in complete resolution of stasis. Improving our understanding of the relationship between serum vitamin D and GBM could help identify dogs as a model for humans with gallbladder hypokinesia. Furthermore, this relationship could provide insight into the pathogenesis of GBM and support the need for future studies to investigate vitamin D as a novel treatment target. Therefore, goals of this study were i) to determine if serum 25-hydroxyvitamin(OH)D concentrations were decreased in dogs with GBM, ii) if serum 25(OH)D concentrations were different in clinical versus dogs subclinical for GBM, and iii) to determine if serum 25(OH)D concentrations could predict the ultrasonographic type of GBM. Sixty-two dogs (clinical, n = 26; subclinical, n = 36) with GBM and 20 healthy control dogs were included in this prospective observational study. Serum 25(OH)D concentrations were measured with a competitive chemiluminescence immunoassay. Overall, dogs with GBM had lower serum 25(OH)D concentrations than control dogs (P = 0.004). Subsequent subgroup analysis indicated that this difference was only significant in the subclinical group compared to the control dogs (P = 0.008), and serum 25(OH)D concentrations did not significantly differ between dogs clinical for GBM versus subclinical or control dogs, indicating that inflammatory state in clinical dogs was not the major constituent of the observed findings. Decreasing serum 25(OH)D concentrations, but not clinical status, was associated with a more advanced developmental stage of GBM type determined by ultrasonography. Our results indicate that vitamin D has a role in dogs with GBM. Additional studies are needed to assess if reduced vitamin D in dogs with GBM is a cause or effect of their biliary disease and to investigate if vitamin D supplementation could be beneficial for dogs with GBM.

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Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele

et al. 2020

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“…The ligation of vitamin D with its receptor results in increased kinetics of muscle contraction (Boyan et al 2003, Ceglia 2008. Another added benefit of vitamin D is that it increases expression of CYP3A4 in mice and humans, a cytochrome P450 enzyme that decreases bile acid hydrophobicity (Makishima et al 2002, Thompson et al 2002, Nishida et al 2009, Jacobs et al 2016. A recent observational study found that decreasing serum 25-hydroxyvitamin(OH) D concentrations was associated with a more advanced developmental stage of GBM type determined by ultrasonography (Jaffey et al 2020).…”

Section: Gall Bladder Mucocelementioning

confidence: 99%

“…2009, Jacobs et al . 2016). A recent observational study found that decreasing serum 25‐hydroxyvitamin(OH)D concentrations was associated with a more advanced developmental stage of GBM type determined by ultrasonography (Jaffey et al .…”

Section: Gall Bladder Mucocelementioning

confidence: 99%

Canine extrahepatic biliary disease

Jaffey

2021

J of Small Animal Practice

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Extrahepatic biliary disease in dogs is commonly encountered in clinical practice worldwide. Diseases in this segment of the biliary tract are diverse and can manifest with mild clinical signs or can be life-threatening. In the last decade there have been advances in diagnostic tests, imaging modalities and therapeutic interventions as well as the identification of novel prognostic variables that could improve outcomes in dogs with extrahepatic biliary disease. Therefore, the objective of this review was to summarise clinically relevant updates of extrahepatic biliary disease in dogs.

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“…Therefore, 56 articles were further assessed for inclusion and 8 articles were excluded (3 included cases with hyperplastic polyps to calculate the risk and 5 did not describe detailed information of CRA history). Finally, 48 eligible articles were included in this systematic review and meta-analysis: 28 articles evaluated the association of vitamin D intake on the risk of CRC precursors occurrence (incidence/recurrence) (27, 28, 39-64), 26 articles evaluated the association between circulating 25(OH)D level and risk of CRC precursors occurrence (incidence/recurrence) (28,39,43,47,50,57,(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84). Supplementary Table 4 summarized the main characteristics of the included studies.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Vitamin D intake as well as circulating 25-hydroxyvitamin D level and risk for the incidence and recurrence of colorectal cancer precursors: A meta-analysis

et al. 2022

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ObjectiveVitamin D consumption and circulating 25(OH)D level are associated with decreased risk of colorectal cancer (CRC) and colorectal adenoma (CRA), but few studies have assessed their relationship with the incidence and recurrence of CRC precursors. Therefore, we performed this meta-analysis to further evaluate the association.MethodsWe searched PubMed, Web of Science, Scopus and Embase databases in English until August 2021. Studies evaluating the association of vitamin D intake and circulating 25(OH)D level with risk of CRC precursors were included. A random-effects model was used to pool the risk estimates.ResultsA total of 48 studies were selected for inclusion. The CRC precursors incidence was negatively correlated with total vitamin D intake (RR = 0.84 95%CI: 0.80–0.88) and circulating 25(OH)D level (RR = 0.79 95%CI: 0.67–0.92). However, vitamin D intake and circulating 25(OH)D level did not show significant effects on the risk of CRC precursors recurrence. For dose-response analysis, evidence of a linear association was found between CRC precursors incidence and circulating 25(OH)D level, and the risk decreased by 14% per 10 ng/ml increment of circulating 25(OH)D level (RR = 0.86 95% CI: 0.75–0.99).ConclusionVitamin D intake and circulating 25(OH)D level can play an effective role in reducing the risk of incidence of CRC precursors. However, they have not prevented the recurrence of CRC precursors.

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Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations

Cited by 9 publications

References 43 publications

Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele

Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele

Canine extrahepatic biliary disease

Vitamin D intake as well as circulating 25-hydroxyvitamin D level and risk for the incidence and recurrence of colorectal cancer precursors: A meta-analysis

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