Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS)

Bonizzoli, Manuela; Arvia, Rosaria; Valvasone, S Di; Liotta, Francesco; Zakrzewska, K.; Azzi, Alberta; Peris, Adriano

doi:10.1007/s00430-016-0456-z

Cited by 25 publications

(30 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of 1 study included codetection with EBV and respiratory viruses [9]; another reported codetection with respiratory viruses, with codetection rates ranging from 2% to 8% [6]. Results of prior studies suggest that infection with influenza and other respiratory viruses might reactivate herpes family viruses [31, 32]. In our study, patients with codetections did not report higher frequency of complications, hospitalizations, or underlying medical conditions compared with patients having samples with single virus detection.…”

Section: Discussionmentioning

confidence: 54%

Non-mumps Viral Parotitis During the 2014–2015 Influenza Season in the United States

Elbadawi

Talley

Rolfes

et al. 2018

Clinical Infectious Diseases

View full text Add to dashboard Cite

Background. During the 2014–2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence. Methods. NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result. Using a standardized questionnaire, we collected demographic and clinical information. Buccal samples were tested at the CDC for selected viruses, including mumps, influenza, human parainfluenza viruses (HPIVs) 1–4, adenoviruses, cytomegalovirus, Epstein-Barr virus (EBV), herpes simplex viruses (HSVs) 1 and 2, and human herpes viruses (HHVs) 6A and 6B. Results. Among the 320 patients, 65% were male, median age was 14.5 years (range, 0–90), and 67% reported unilateral parotitis. Commonly reported symptoms included sore throat (55%) and fever (48%). Viruses were detected in 210 (71%) of 294 NMP patients with adequate samples for testing, ≥2 viruses were detected in 37 samples, and 248 total virus detections were made among all samples. These included 156 influenza A(H3N2), 42 HHV6B, 32 EBV, 8 HPIV2, 2 HPIV3, 3 adenovirus, 4 HSV-1, and 1 HSV-2. Influenza A(H3N2), HHV6B, and EBV were the most frequently codetected viruses. Conclusions. Our findings suggest that, in addition to mumps, clinicians should consider respiratory viral (influenza) and herpes viral etiologies for parotitis, particularly among patients without epidemiologic links to mumps cases or outbreaks.

show abstract

Section: Discussionmentioning

confidence: 54%

Non-mumps Viral Parotitis During the 2014–2015 Influenza Season in the United States

Elbadawi

Talley

Rolfes

et al. 2018

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…The AUC was 0.369 (95% CI 0.292 to 0.446) for age, 0.425 (95% CI 0.345 to 0.505) for the APACHE II score, and 0.355 (95% CI 0.278 to 0.433) for the SOFA score (not shown) During the past decade, there have been a few investigations addressing the potential function of the lymphocyte/neutrophil ratio, which remains a useful test for the diagnosis of tuberculous pleuritis [19] and acts as an early biomarker for predicting acute rejection after heart transplantation [20]. Previous studies have focused on the poor prognosis of patients with severe lymphopenia from the first day of ICU admission [21]. In our study, peripheral blood lymphopenia was very common in ARDS patients without typical underlying diseases, causing immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for ARDS: clinical, physiological and atypical immunodeficiency

Song

Liu

et al. 2020

BMC Pulm Med

View full text Add to dashboard Cite

Background: Risk factors affecting the prognosis of acute respiratory distress syndrome (ARDS) in adults were investigated. The aim was to identify new predictors for ARDS patient prognosis, including those with clinical, pathophysiological, and atypical immunodeficiency. Methods: ARDS patients were retrospectively included. The patients were grouped and analysed according to different oxygenation index grades and prognosis, and factors influencing prognosis and survival were examined. Adolescent patients, patients with typical immunodeficiency and patients who died within 24 h after being diagnosed with ARDS were excluded. The predictive value for mortality was determined by Cox proportional hazard analysis. Results: In total, 201 patients who fulfilled the Berlin definition of ARDS were included. The severity of critical illness on the day of enrolment, as measured by the Acute Physiology and Chronic Health Evaluation (APACHE) II score (P = 0.016), Sequential Organ Failure Assessment (SOFA) score (P = 0.027), and PaO 2 /FiO 2 (P = 0.000), worsened from mild to severe ARDS cases. Compared with survivors, non-survivors were significantly older and had higher APACHE II and SOFA scores. Moreover, significantly lower lymphocyte/neutrophil ratios and leukocyte counts were found among non-survivors than survivors (P = 0.008, P = 0.012). A moderate positive correlation between the lymphocyte/ neutrophil and PaO 2 /FiO 2 ratios (P = 0.023) was observed. In predicting 100-day survival in patients with ARDS, the area under the curve (AUC) for the lymphocyte/neutrophil ratio was significantly higher than those for the PaO 2 / FiO 2 ratio alone, body mass index (BMI) alone, and the lymphocyte count alone (P = 0.0062, 0.0001, and 0.0154). Age (per log 10 years), BMI < 24, SOFA score, leukocyte count, and the lymphocyte/neutrophil ratio were independent predictors of 28-day mortality in ARDS patients. Additionally, ARDS patients with a lymphocyte/ neutrophil ratio < 0.0537 had increased 28-day mortality rates (P = 0.0283). Old age affected both 28-day and 100day mortality rates (P = 0.0064,0.0057).

show abstract

“…Previous studies focused on early T-cell lymphopenia, which has been widely attributed to viral infection, and patients with a poor prognosis had severe lymphopenia from the first day of ICU admission [29]. In our study, it was found that peripheral blood lymphopenia was very common in ARDS patients without typical underlying diseases causing immunosuppression.…”

Section: Discussionmentioning

confidence: 51%

“…In particular, a clear reduction in the number of circulating lymphocytes was evident in this group when compared to the group of patients discharged from the intensive care unit (ICU). The reduction in lymphocytes involves all lymphocyte populations: T (CD3+), B (CD19+) and NK cells (CD3CD16/56+) [13]. A high neutrophil-to-lymphocyte ratio (NLR) was associated with poor outcomes in critically ill patients with ARDS [14,15].…”

mentioning

confidence: 99%

Prognostic factors for ARDS: clinical, physiological and atypical immunodeficiency

Song

Liu

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: The risk factors affecting the prognosis of acute respiratory distress syndrome (ARDS) in adults were investigated. The aim was to identify new predictors of prognosis in ARDS patients, including those with clinical, pathophysiological, and atypical immunodeficiency. Methods: ARDS patients were retrospectively included. Patients were grouped and analysed according to different oxygenation index grades and prognosis, and the factors influencing prognosis and survival were analysed. Adolescent patients, patients with typical immunodeficiency and patients who died within 24 hours after being diagnosed with ARDS were excluded. The predictive value for mortality was determined by Cox proportional hazard analysis. Results: In total, 201 patients who fulfilled the Berlin definition of ARDS were included. The severity of critical illness on the day of enrolment, as measured by the Acute Physiology and Chronic Health Evaluation (APACHE) II score (P<0.05), Sequential Organ Failure Assessment (SOFA) score ( P<0.05 ), and PaO 2 /FiO 2 (P<0.001), worsened from mild to severe ARDS. Compared with survivors, non-survivors had significantly older age and higher APACHE II and SOFA scores. Moreover, significantly lower lymphocyte/neutrophil ratios and leukocyte counts were found in non-survivors than in survivors (P<0.01, P<0.05). Furthermore, there was a moderate positive correlation between the lymphocyte/neutrophil and PaO 2 /FiO 2 ratios (P<0.05). The area under the curve (AUC) for the lymphocyte/neutrophil ratio was significantly greater than those for the body mass index (BMI) alone, PaO 2 /FiO 2 ratio alone, and lymphocyte/neutrophil ratio alone for predicting 100-day survival in patients with ARDS (P=0.0062, 0.0001, and 0.0154). Age (per log 10 years), BMI<24, the SOFA score, leukocyte count, and the lymphocyte/neutrophil ratio were independent predictors of 28-day mortality in ARDS patients. Moreover, ARDS patients with a lymphocyte/neutrophil ratio <0.0537 had elevated 28-day mortality (P<0.05). Old age affected both 28-day and 100-day mortality (P<0.05). Conclusions: Age (per log 10 years), BMI<24, SOFA score, lymphocytes, and the lymphocyte/neutrophil ratio were independent predictors of 100-day mortality in patients with ARDS. The lymphocyte/neutrophil ratio may represent a potential molecular marker to evaluate atypical immunosuppression or impairment in patients with ARDS.

show abstract

Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS)

Cited by 25 publications

References 34 publications

Non-mumps Viral Parotitis During the 2014–2015 Influenza Season in the United States

Non-mumps Viral Parotitis During the 2014–2015 Influenza Season in the United States

Prognostic factors for ARDS: clinical, physiological and atypical immunodeficiency

Prognostic factors for ARDS: clinical, physiological and atypical immunodeficiency

Contact Info

Product

Resources

About