Phenotype of sarcopenic obesity in older individuals with a history of falling

Huo, Ya Ruth; Suriyaarachchi, Pushpa; Gómez, Fernando; Curcio, Carmen-Lucía; Boersma, Derek; Gunawardene, Piumali; Demontiero, Oddom; Duque, Gustavo

doi:10.1016/j.archger.2016.04.003

Cited by 46 publications

(68 citation statements)

References 24 publications

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“…Another prospective study with more than 3000 older adults demonstrated that body fat to fat-free mass ratio predicts incident physical limitation in both genders. 28 According to The Concord Health and Ageing in Men Project, compared with non-sarcopenic non-obese men, sarcopenic obese men had the highest incidence rate ratio (2.4-fold) of falls. 31 Although the association between increased fall risk and sarcopenia can be shown even with meta-analysis, the relationship between sarcopenic obesity and falls has just begun to emerge in the studies.…”

Section: Discussionmentioning

confidence: 99%

Health‐related quality of life and fall risk associated with age‐related body composition changes; sarcopenia, obesity and sarcopenic obesity

Öztürk

Türkbeyler

Abiyev

et al. 2018

Internal Medicine Journal

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Section: Discussionmentioning

confidence: 99%

Health‐related quality of life and fall risk associated with age‐related body composition changes; sarcopenia, obesity and sarcopenic obesity

Öztürk

Türkbeyler

Abiyev

et al. 2018

Internal Medicine Journal

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“…SMM/ht 2 , aSMM/ht 2 , and SMM alone were consistently predictive of incident osteoporosis, while the prognostic significance of the residuals were less consistent across subgroups and mostly absent for SMM/bm × 100 and aSMM/BMI. Previous studies have explored the combined effects of increased adiposity and muscle mass or strength on osteoporosis . By identifying sarcopenic individuals as those fulfilling at least two of the following three criteria with specific cut‐offs, that is, low aLM/ht 2 , gait velocity, and grip strength, Huo et al .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have explored the combined effects of increased adiposity and muscle mass or strength on osteoporosis . By identifying sarcopenic individuals as those fulfilling at least two of the following three criteria with specific cut‐offs, that is, low aLM/ht 2 , gait velocity, and grip strength, Huo et al . demonstrated in 680 elderly men and women (mean age: 79 ± 9 years, 65% female) that sarcopenic obesity was significantly associated with a lower hip BMD compared with non‐sarcopenic obesity (T‐score −1.39 ± 1.24 vs. −0.79 ± 1.33; P < 0.01).…”

Section: Discussionmentioning

confidence: 99%

Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women

Papageorgiou

Sathyapalan

Schutte

2018

J cachexia sarcopenia muscle

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Background Despite several muscle mass measures being used in the current definitions of sarcopenia, their usefulness is uncertain because of limited data on their association with health outcomes. The aim of the study was to compare the performance of different muscle mass measures for predicting incident osteoporosis in postmenopausal women. Methods This study included data from 149 166 participants (aged 60.3 ± 5.5 years) as part of the UK Biobank cohort. Body composition was assessed using bioelectrical impedance. The muscle mass measures included were total body skeletal muscle mass (SMM) and appendicular SMM (aSMM) divided by height squared (ht 2 ), derived residuals, SMM, SMM adjusted for body mass (SMM/bm × 100), and aSMM normalized for body mass index (aSMM/BMI). Diagnoses of the events were confirmed by primary care physicians and coded according to the World Health Organization's International Classification of Diseases 10th Revision (ICD‐10: M80‐M82). Results Over a median follow‐up of 6.75 (5th to 95th percentile interval, 1.53 to 8.37) years, 394 newly diagnosed cases of osteoporosis occurred, with 40 (10.2%) cases being associated with a pathological fracture. SMM/ht 2 , aSMM/ht 2 residual, and SMM were lower in postmenopausal women with osteoporosis compared with women without (all P < 0.0001), while SMM/bm × 100 ( P = 0.003), but not aSMM/BMI ( P = 0.59), was higher in the osteoporosis group. The unadjusted rates of osteoporosis increased with decreasing quintiles for SMM/ht 2 , aSMM/ht 2 , residuals, and SMM (all P trend <0.0001), while the incidence of osteoporosis increased with increasing SMM/bm × 100 ( P trend =0.001), but not for aSMM/BMI ( P = 0.45). After minimally adjusting for age and after full adjustment, SMM/ht 2 , aSMM/ht 2 , and SMM were the only measure that consistently predicted osteoporosis in the total group of postmenopausal women [hazard ratio (HR) 0.65–0.67, all P ≤ 0.0001], in lean women (HR 0.62–0.68; all P ≤ 0.001), and women with increased adiposity (HR 0.64–0.68; all P ≤ 0.01). In fully adjusted models, the changes in the R 2 statistic were 13.4%, 11.6%, and 15.3% for the SMM/ht 2 (aSMM/ht 2 ), residual, and SMM, but only 4.9% and 1.3% for SMM/bm × 100 and aSMM/BMI. Conclusions Muscle mass measures adjusted for height only (SMM/ht 2 , aSMM/ht 2 ) appear to be better muscle‐re...

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“…. Other definitions are based on both low muscle mass and low muscle strength/physical performance: European Working Group on Sarcopenia in Older People (EWGSOP), Asian Working Group for Sarcopenia (AWGS), Foundation for the National Institutes of Health (FNIH), International Working Group on Sarcopenia (IWGS), Society for Sarcopenia, Cachexia, and Wasting Disorders (SCWD), and ESPEN Special Interest Group on ‘cachexia‐anorexia in chronic wasting diseases’ and ‘nutrition in geriatrics’ . In cases where studies applied multiple sarcopenia definitions, results based on the EWGSOP definition were prioritized over the Baumgartner definition and other definitions …”

Section: Methodsmentioning

confidence: 99%

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Yeung

Reijnierse

Pham

et al. 2019

J cachexia sarcopenia muscle

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463

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Sarcopenia is a potentially modifiable risk factor for falls and fractures in older adults, but the strength of the association between sarcopenia, falls, and fractures is unclear. This study aims to systematically assess the literature and perform a meta‐analysis of the association between sarcopenia with falls and fractures among older adults. A literature search was performed using MEDLINE, EMBASE, Cochrane, and CINAHL from inception to May 2018. Inclusion criteria were the following: published in English, mean/median age ≥ 65 years, sarcopenia diagnosis (based on definitions used by the original studies' authors), falls and/or fractures outcomes, and any study population. Pooled analyses were conducted of the associations of sarcopenia with falls and fractures, expressed in odds ratios (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed by study design, population, sex, sarcopenia definition, continent, and study quality. Heterogeneity was assessed using the I 2 statistics. The search identified 2771 studies. Thirty‐six studies (52 838 individuals, 48.8% females, and mean age of the study populations ranging from 65.0 to 86.7 years) were included in the systematic review. Four studies reported on both falls and fractures. Ten out of 22 studies reported a significantly higher risk of falls in sarcopenic compared with non‐sarcopenic individuals; 11 out of 19 studies showed a significant positive association with fractures. Thirty‐three studies (45 926 individuals) were included in the meta‐analysis. Sarcopenic individuals had a significant higher risk of falls (cross‐sectional studies: OR 1.60; 95% CI 1.37–1.86, P < 0.001, I 2 = 34%; prospective studies: OR 1.89; 95% CI 1.33–2.68, P < 0.001, I 2 = 37%) and fractures (cross‐sectional studies: OR 1.84; 95% CI 1.30–2.62, P = 0.001, I 2 = 91%; prospective studies: OR 1.71; 95% CI 1.44–2.03, P = 0.011, I 2 = 0%) compared with non‐sarcopenic individuals. This was independent of study design, population, sex, sarcopenia definition, continent, and study quality. The positive association between sarcopenia with falls and fractures in older adults strengthens the need to invest in sarcopenia prevention and interventions to evaluate its effect on falls and fractures.

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Phenotype of sarcopenic obesity in older individuals with a history of falling

Cited by 46 publications

References 24 publications

Health‐related quality of life and fall risk associated with age‐related body composition changes; sarcopenia, obesity and sarcopenic obesity

Health‐related quality of life and fall risk associated with age‐related body composition changes; sarcopenia, obesity and sarcopenic obesity

Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

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