International cancer seminars: a focus on kidney cancer

Scélo, Ghislaine; Hofmann, Jonathan N.; Banks, Rosamonde E.; Bigot, Pierre; Bhatt, Rupal S.; Cancel‐Tassin, Géraldine; Chew, Su Kit; Creighton, Chad J.; Cussenot, Olivier; Davis, Ian J.; Escudier, Bernard; Frayling, Timothy M.; Häggström, Christel; Hildebrandt, Michelle A.T.; Holcátová, Ivana; Johansson, Mattias; Linehan, W. Marston; McDermott, David F.; Nathanson, Katherine L.; Ogawa, Seishi; Perlman, Elizabeth J.; Purdue, Mark P.; Stattin, P.; Swanton, Charles; Vasudev, Naveen S.; Wu, Xifeng; Znaor, Ariana; Chanock, Stephen J.

doi:10.1093/annonc/mdw186

Cited by 21 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patient and carer involvement throughout this work was critical. Indeed, our work identified different RGs to a previous RCC initiative not directly involving patients, which placed greater emphasis on understanding tumour biology, genomic and epigenetic factors and epidemiology (10). Conversely, initiatives in which patient participation was central, uncovered RGs across similar overarching themes highlighted by our work, including early detection, personalised patient management and follow up (11).…”

mentioning

confidence: 83%

“…EU Focus represents the most contemporary and systematic priority setting initiative in RCC to date, focusing on a European setting (9)(10)(11). Although the majority of participants represent a UK and European setting, a Canadian project published in European Urology identified overlapping research priorities suggesting these may be common to all Western settings (11).…”

Section: The Work Described Inmentioning

confidence: 99%

See 1 more Smart Citation

Setting Research Priorities in Partnership with Patients to Provide Patient-centred Urological Cancer Care

et al. 2019

View full text Add to dashboard Cite

mentioning

confidence: 83%

Section: The Work Described Inmentioning

confidence: 99%

Setting Research Priorities in Partnership with Patients to Provide Patient-centred Urological Cancer Care

et al. 2019

View full text Add to dashboard Cite

“…11 Enhanced molecular characterization has led to a better understanding of the complexity of the disease, with six new codes approved by the International Agency for Research on Cancer (IARC)/World Health Organization (WHO) Committee for International Classification of Diseases for Oncology (ICD-O) included in the new WHO Classification of the Tumours of the Urinary System and Male Genital Organs 12 ; yet many research questions still remain difficult to answer: including specific factors explaining geographical, ethnic and sex differences, the biological pathways underlying the association with known risk factors; and the critical data required to understand genomic and epigenetic changes. 13 In a previous study, we reported increasing kidney cancer incidence trends from 33 of 43 analyzed populations worldwide, the report pointing to both global increases in obesity and an increasing use of imaging with incidental diagnosis as possible explanatory factors. 5 Using incidence data covering years 1978-2007, the aim of this study is to elucidate the reasons for the increasing kidney cancer incidence by investigating the role of birth cohort (a surrogate for increased exposures to environmental risk factors, such as obesity, operating in successive generations) and period-specific effects (commonly a proxy for changes in diagnostic practices or disease classification).…”

mentioning

confidence: 85%

Less overdiagnosis of kidney cancer? an age‐period‐cohort analysis of incidence trends in 16 populations worldwide

Znaor

Laversanne

Bray

2017

Intl Journal of Cancer

View full text Add to dashboard Cite

The increasing rates of kidney cancer incidence, reported in many populations globally, have been attributed both to increasing exposures to environmental risk factors, as well as increasing levels of incidental diagnosis due to widespread use of imaging. To better understand these trends, we examine long-term cancer registry data worldwide, focusing on the roles of birth cohort and calendar period, proxies for changes in risk factor prevalence and detection practice respectively. We used an augmented version of the Cancer Incidence in Five Continents series to analyze kidney cancer incidence rates 1978-2007 in 16 geographically representative populations worldwide by sex for ages 30-74, using age-period-cohort (APC) analysis. The full APC model provided the best fit to the data in most studied populations. While kidney cancer incidence rates have been increasing in successive generations born from the early twentieth century in most countries, equivalent period-specific rises were observed from the late-1970s, although these have subsequently stabilized in certain European countries (the Czech Republic, Lithuania, Finland, Spain) as well as Japan from the mid-1990s, and from the mid-2000s, in Colombia, Costa Rica and Australia. Our results indicate that the effects of both birth cohort and calendar period contribute to the international kidney cancer incidence trends. While cohort-specific increases may partly reflect the rising trends in obesity prevalence and the need for more effective primary prevention policies, the attenuations in period-specific increases (observed in 8 of the 16 populations) highlight a possible change in imaging practices that could lead to mitigation of overdiagnosis and overtreatment.

show abstract

“…Three histological subtypes: clear cell (ccRCC), papillary (pRCC), and chromophobe (chRCC) account for 85-90% of all RCC cases [1]. The incidence of RCC is constantly increasing in North America and Europe [2] with the exception of Finland and Estonia where it has been stable [3]. The majority of cases (80%) occur after the age of 40 years, and the incidence rate is higher among men compared with women (3 : 2) [4].…”

Section: Introductionmentioning

confidence: 99%

The effect of antioxidant status on overall survival in renal cell carcinoma

Pavlović¹,

Pejić²,

Radojević-Škodrić³

et al. 2020

aoms

View full text Add to dashboard Cite

Introduction: The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients. Material and methods: Our study included 95 patients with RCC, who underwent radical nephrectomy. We analysed the prognostic role of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glutathione, and malondialdehyde) and other clinicopathological factors (size, grade, stage, and histological subtype) on the OS of RCC patients. Results: The 5-year OS was 54.6%. The survival analysis related to AO parameters showed no significant difference in survival of RCC patients. The concentration of malondialdehyde, an indicator of lipid peroxidation, also had no significant effect on the survival rate of RCC patients. Univariate and multivariate analysis confirmed the significance of clinicopathological parameters (size, p < 0.001; Fuhrman grade, p = 0.001, and stage, p < 0.001) for patients' survival. Conclusions: In our cohort of patients, different antioxidant parameters were not found to be predictors for OS of patients with RCC, who underwent radical nephrectomy.

show abstract

International cancer seminars: a focus on kidney cancer

Cited by 21 publications

References 31 publications

Setting Research Priorities in Partnership with Patients to Provide Patient-centred Urological Cancer Care

Setting Research Priorities in Partnership with Patients to Provide Patient-centred Urological Cancer Care

Less overdiagnosis of kidney cancer? an age‐period‐cohort analysis of incidence trends in 16 populations worldwide

The effect of antioxidant status on overall survival in renal cell carcinoma

Contact Info

Product

Resources

About