Affective responses across psychiatric disorders—A dimensional approach

Hägele, Claudia; Friedel, Eva; Schlagenhauf, Florian; Sterzer, Philipp; Beck, Anne; Bermpohl, Felix; Stoy, Meline; Held-Poschardt, Dada; Wittmann, André; Ströhle, Andreas; Heinz, Andreas

doi:10.1016/j.neulet.2016.04.037

Cited by 35 publications

(25 citation statements)

References 85 publications

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“…Indeed, in a recent study of 135 patients with a variety of psychiatric disorders, no group differences in amygdala activation to negative pictures were observed, nor were any correlations with anxiety or depressive symptoms observed across groups (Hägele et al, 2016; see also Müller et al, 2017). Results observed here suggest that amygdala hyperactivation to negative faces may not be evident across all anxiety and depressive patients.…”

Section: No Significant Findingscontrasting

confidence: 49%

“…Nonetheless, fMRI evidence in support of this notion has been somewhat inconsistent (e.g., Lanius, Bluhm, Lanius, & Pain, ; Palm, Elliott, McKie, Deakin, & Anderson, ; Thomas et al., ; Whalen et al., ). Indeed, in a recent study of 135 patients with a variety of psychiatric disorders, no group differences in amygdala activation to negative pictures were observed, nor were any correlations with anxiety or depressive symptoms observed across groups (Hägele et al., ; see also Müller et al., ). Results observed here suggest that amygdala hyperactivation to negative faces may not be evident across all anxiety and depressive patients.…”

Section: Discussionmentioning

confidence: 98%

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Transdiagnostic neural correlates of affective face processing in anxiety and depression

et al. 2017

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Background It is unknown whether there are neurobiological differences between various anxiety and depressive disorders, or whether they are characterized by shared neurobiological variation that cuts across diagnostic boundaries. For instance, multiple anxiety disorders and depression may be characterized by abnormalities in blood-oxygen-level dependent (BOLD) response during the processing of affective scenes and faces. To interrogate the shared or unique nature of these aberrations, research that examines the influence of transdiagnostic, dimensional predictors across multiple diagnoses is needed. Methods One-hundred and ninety-nine individuals, 142 with primary diagnoses of social anxiety disorder (SAD), generalized anxiety disorder (GAD) or major depressive disorder (MDD), and 57 who were free from psychiatric diagnoses (healthy controls, HCs) performed a face-matching task involving fearful, angry and happy faces (and geometric shapes) while undergoing functional magnetic resonance imaging. Results Across the three primary diagnoses, anxiety symptom scores were associated with increased Angry>Shapes activation in the bilateral insula, anterior/midcingulate and dorsolateral prefrontal cortex (dlPFC), while depressive symptoms were associated with reduced dlPFC activation for Angry>Shapes. Patient>HC differences were limited to non a priori regions, and no differences in BOLD activation were observed between diagnostic groups. Conclusions 1) Activation in paralimbic, cingulate and lateral prefrontal regions in response to angry faces is associated with transdiagnostic anxiety and depressive symptomatology. 2) Anxiety and depressive symptoms may exert opposing influences on lateral prefrontal activation. 3) Abnormal threat processing in GAD, SAD and MDD may reflect shared neural dysfunction that varies with symptom load.

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Section: No Significant Findingscontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 98%

Transdiagnostic neural correlates of affective face processing in anxiety and depression

et al. 2017

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“…The lack of significant differences between the depressed patients and the healthy controls in our study is in line with the negative findings of Hägele et al in their transdiagnostic study across different psychiatric disorders (including alcohol dependence, schizophrenia, major depressive disorder, manic episode of bipolar disorders, and attention deficit hyperactivity disorders). Their study design is very similar to ours, and they have used the same statistical level of significance P < .05 FWE‐corrected for the whole brain.…”

Section: Discussionsupporting

confidence: 92%

Application of functional magnetic resonance imaging in psychiatric clinical evaluation: Controversies and avenues

Kandilarova

Stoyanov

Popivanov

et al. 2018

Evaluation Clinical Practice

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Although the within-group analysis demonstrated significant activations in both groups with apparent discrepancies, the between-group analysis did not reach statistical significance under the stringent criteria for statistical inference. These results are further contextualized in the critical debate on the methodological issues of clinical evaluation in psychiatry, more specifically the validity and consistency of the applied methods and the limitations existing in the attempts to provide sound cross-disciplinary validation of the diagnostic tools by means of neuroscience.

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“…In addition, although numerous prior studies report overactive amygdala in response to varied negative stimuli (e.g., scenes, faces, and words), there are also number of studies that fail to find such effects in those with GAD and SAD (Blair et al, 2008; Grimm et al, 2008;Irwin et al, 2004;Lawrence et al, 2004;Townsend et al, 2010). As a result, amygdala response to these types of stimuli may not be strongly associated with anxiety and depression symptoms, suggesting that this neural trait may not best characterize these disorders (Hägele et al, 2016). In addition, recent metaanalytical work found no elevated amygdala reactivity during reappraisal in individuals with anxiety and depressive disorders (Picó-Pérez et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression

et al. 2018

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Background: Individuals who suffer from anxiety and/or depression face difficulty in adaptively managing emotional responses, while accumulating evidence suggests impaired emotion regulation is a transdiagnostic feature of psychopathology. Effectual regulation in the context of negative stimuli is characterized by engagement of the prefrontal cortex (PFC) coupled with reduced amygdala reactivity. In anxiety disorders and major depression, PFC underengagement and atypical PFC-amygdala connectivity has been observed, although patient findings based on case-control studies have been mixed with regard to magnitude, locality, and extent of dysfunction. As anxiety disorders and major depression are heterogeneous disorders and frequently comorbid with one another, delineating relationships between reappraise-related substrates and symptoms may advance our understanding of emotion dysregulation in these populations. Methods:We examined PFC activation and its functional connectivity (FC) to the amygdala using functional magnetic resonance imaging in a large sample of patients (N = 174) with primary generalized anxiety disorder (n = 47), social anxiety disorder (n = 78), or major depressive disorder (n = 49) during a reappraisal-based emotion regulation task. Comorbidity was permitted and the majority of participants had a concurrent psychiatric illnesses.Results: Across participants, whole-brain results showed that (1) greater anxiety and depression symptom severity was related to less engagement of the dorsal anterior cingulate cortex (ACC) and (2) less FC between the amygdala and ventrolateral PFC. Results were driven by anxiety, while depression symptoms were not significant.Conclusion: These findings demonstrate that individual differences in anxiety and depression may help explain ACC and PFC dysfunction during emotion regulation observed across anxiety and depressive disorders. K E Y W O R D Sanxiety/anxiety disorders, depression, functional MRI, generalized anxiety disorder, social anxiety disorder/social phobia

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Affective responses across psychiatric disorders—A dimensional approach

Cited by 35 publications

References 85 publications

Transdiagnostic neural correlates of affective face processing in anxiety and depression

Transdiagnostic neural correlates of affective face processing in anxiety and depression

Application of functional magnetic resonance imaging in psychiatric clinical evaluation: Controversies and avenues

Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression

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