Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells

Takito, Jiro; Kimura, Junko; Koyama, Koji; Uozumi, Nobuyuki; Watanabe, Makoto; Yokosuka, Akihito; Mimaki, Yoshihiro; Nakamura, Masanori; Ohizumi, Yasushi

doi:10.1139/cjpp-2015-0394

Cited by 7 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nagase et al previously reported that nobiletin inhibits the phosphodiesterase (PDE) activity catalyzing the hydrolysis of cAMP, thereby increasing the intracellular cAMP concentration to activate PKA in PC12D cells [69]. Moreover, nobiletin induced CREB phosphorylation in an ERK kinase (MEK)/ERK-dependent manner [19,70,71]. Of note, it also reversed the sublethal Aβ-induced decrease in CREB phosphorylation in cultured hippocampal neurons [23].…”

Section: Effects Of Nobiletin In Cultured Cells and Slicesmentioning

confidence: 99%

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

Nakajima

Ohizumi

2019

IJMS

Self Cite

158

View full text Add to dashboard Cite

Alzheimer’s disease (AD), which is characterized by the presence of amyloid-β (Aβ) plaques and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of age-related neurodegenerative disease. Parkinson’s disease (PD) is the second most common neurodegenerative disease after AD, and is characterized by early prominent loss of dopaminergic neurons in the substantia nigra pars compacta. As currently available treatments are not able to significantly alter the progression of these diseases, successful therapeutic and preventive interventions are strongly needed. In the course of our survey of substances from natural resources having anti-dementia and neuroprotective activity, we found nobiletin, a polymethoxylated flavone from the peel of Citrus depressa. Nobiletin improved cognitive deficits and the pathological features of AD, such as Aβ pathology, hyperphosphorylation of tau, and oxidative stress, in animal models of AD. In addition, nobiletin improved motor and cognitive deficits in PD animal models. These observations suggest that nobiletin has the potential to become a novel drug for the treatment and prevention of neurodegenerative diseases such as AD and PD.

show abstract

Section: Effects Of Nobiletin In Cultured Cells and Slicesmentioning

confidence: 99%

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

Nakajima

Ohizumi

2019

IJMS

Self Cite

158

View full text Add to dashboard Cite

show abstract

“…Nobiletin is a PMF mainly found in the peel of citrus fruit [ 18 ] and in fruit pulp. It has been reported to improve various disorders such as Alzheimer’s disease [ 19 , 20 ], inflammation, and metabolic syndrome [ 21 – 24 ] in animals. Recently, a relationship between nobiletin, obesity, and circadian rhythm in mice has been reported [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts

et al. 2017

View full text Add to dashboard Cite

Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids on obesity and numerous diseases such as cancer, diabetes, and Alzheimer’s have been well studied. However, little is known about the relationships between flavonoids and the circadian clock. In this study, we show that continuous or transient application of flavonoids to the culture medium of embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications in the circadian clock amplitude, period, and phase. Transient application of some of the tested flavonoids to cultured cells induced a phase delay of the PER2::LUC rhythm at the down slope phase. In addition, continuous application of the polymethoxy flavonoids nobiletin and tangeretin increased the amplitude and lengthened the period of the PER2::LUC rhythm. The nobiletin-induced phase delay was blocked by co-treatment with U0126, an ERK inhibitor. In summary, among the tested flavonoids, polymethoxy flavones increased the amplitude, lengthened the period, and delayed the phase of the PER2::LUC circadian rhythm. Therefore, foods that contain polymethoxy flavones may have beneficial effects on circadian rhythm disorders and jet lag.

show abstract

“…Pathways related to nobiletin in cognitive dysfunction. Nobiletin protects hippocampal neurons through the cAMP/PKA/ERK/CREB signalling pathways and improves learning and memory ability [ 11 , 24 , 38 , 39 , 58 ]. Nobiletin and nerve growth factor act together to increase the phosphorylation level of ERK and activate CRE-dependent transcription [ 58 ].…”

Section: Effect and Mechanisms Of Nobiletin In The Cnsmentioning

confidence: 99%

“…Nobiletin protects hippocampal neurons through the cAMP/PKA/ERK/CREB signalling pathways and improves learning and memory ability [ 11 , 24 , 38 , 39 , 58 ]. Nobiletin and nerve growth factor act together to increase the phosphorylation level of ERK and activate CRE-dependent transcription [ 58 ]. Intraperitoneal injection of 10 or 50 mg/kg 4-demethylnobiletin can improve NMDA receptor dysfunction-induced cognitive dysfunction via the PKA/ERK/CREB pathway [ 2 ].…”

Section: Effect and Mechanisms Of Nobiletin In The Cnsmentioning

confidence: 99%

A review on recent advances on nobiletin in central and peripheral nervous system diseases

Pang,

Xiong,

et al. 2023

Eur J Med Res

View full text Add to dashboard Cite

In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited. Nobiletin, as a compound with high fat solubility, high bioavailability and low toxicity, has been extensively studied. Accumulating scientific evidence has shown that nobiletin has a variety of biological functions in the nervous system, such as inhibiting the expression of inflammatory factors, reducing the neurotoxic response, improving the antioxidant capacity, promoting the survival of nerve cells, promoting axon growth, reducing blood‒brain barrier permeability, reducing brain oedema, promoting cAMP response element binding protein expression, improving memory, and promoting mild depolarization of nerve cell mitochondria to improve antioxidative stress capacity. Accumulating studies have shown that nobiletin also protects enteric nervous system, spinal cord and sciatic nerve. To explore the new therapeutic potential of nobiletin in the nervous system, recent and relevant research progress is reviewed in this article. This will provide a new research idea for nobiletin in the nervous system.

show abstract

Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells

Abstract: Keyword:alzheimer disease, CRE-dependent transcription, nerve growth factor, nobiletin, PC12 cells https://mc06.manuscriptcentral.com/cjpp-pubs

Cited by 7 publications

References 33 publications

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts

A review on recent advances on nobiletin in central and peripheral nervous system diseases

Contact Info

Product

Resources

About