Accidental intralenticular dexamethasone intravitreal implant with the resolution of macular oedema in central retinal vein occlusion

Abdolrahimzadeh, Solmaz; Plateroti, Pasquale; Scarinci, Fabio; Plateroti, Andrea Maria

doi:10.1111/aos.13062

Cited by 12 publications

(11 citation statements)

References 6 publications

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“…Despite its intralenticular location, the implant may still improve or resolve macular edema, as intended [ 1 , 7 , 8 , 9 ] and as was seen in our patient. The achievement of therapeutic vitreous concentration levels despite complete sequestration within the lens is also unknown.…”

Section: Discussionsupporting

confidence: 50%

“…The achievement of therapeutic vitreous concentration levels despite complete sequestration within the lens is also unknown. The implant may be partially intralenticular and partially intravitreal; in these cases, macular edema has been observed to remain resolved for up to 8 months following injection [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is delivered via a prepackaged 22-gauge injection device. The literature reveals previous cases of inadvertent intralenticular administration of Ozurdex [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. We report the case of a 60-year-old woman who was found to have an Ozurdex implant in the crystalline lens of the left eye in the setting of previously treated proliferative diabetic retinopathy with refractory diabetic macular edema (DME).…”

Section: Introductionmentioning

confidence: 99%

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Intralenticular Ozurdex® – One Year Later

Regan

Blake

Lukowski

et al. 2017

Case Rep Ophthalmol

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Reported here is a case of intralenticular sustained-release dexamethasone implant (Ozurdex®, Allergan, Irvine, CA, USA) present for 1 year with effective treatment of refractory diabetic macular edema without rapid cataract formation. The crystalline lens remained stable for 12 months on exam despite the presence of the steroid-secreting foreign body. The diabetic macular edema resolved on exam and on optical coherence tomography. After 1 year, cataract extraction was uneventfully performed by phacoemulsification for a mild decline in visual acuity. Macular edema remains resolved 2 months following cataract removal. This is the longest reported period of observation of intralenticular Ozurdex in the literature. Ozurdex remains effective despite intralenticular location, and it can have minimal effects on cataract progression.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intralenticular Ozurdex® – One Year Later

Regan

Blake

Lukowski

et al. 2017

Case Rep Ophthalmol

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“…No new safety concerns were identified with ranibizumab or dexamethasone intravitreal implant treatment in this study (Abdolrahimzadeh et al. ). Overall, the incidences of ocular and non‐ocular AEs were higher with dexamethasone than with ranibizumab treatment.…”

Section: Discussionmentioning

confidence: 84%

Head‐to‐head comparison of ranibizumab PRN versus single‐dose dexamethasone for branch retinal vein occlusion (COMRADE‐B)

Hattenbach

Feltgen

Bertelmann

et al. 2017

Acta Ophthalmologica

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“… 22 Furthermore, with the advent of intravitreal injections and steroid implants in various pathologies, it is a useful tool to evaluate complications such as injection or migration of implants in the anterior segment. 23 – 25 …”

Section: Clinical Applications Of Ubmmentioning

confidence: 99%

A review of the role of ultrasound biomicroscopy in glaucoma associated with rare diseases of the anterior segment

Mannino¹,

Abdolrahimzadeh²,

Calafiore³

et al. 2016

OPTH

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Ultrasound biomicroscopy is a non-invasive imaging technique, which allows high-resolution evaluation of the anatomical features of the anterior segment of the eye regardless of optical media transparency. This technique provides diagnostically significant information in vivo for the cornea, anterior chamber, chamber angle, iris, posterior chamber, zonules, ciliary body, and lens, and is of great value in assessment of the mechanisms of glaucoma onset. The purpose of this paper is to review the use of ultrasound biomicroscopy in the diagnosis and management of rare diseases of the anterior segment such as mesodermal dysgenesis of the neural crest, iridocorneal endothelial syndrome, phakomatoses, and metabolic disorders.

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Accidental intralenticular dexamethasone intravitreal implant with the resolution of macular oedema in central retinal vein occlusion

Cited by 12 publications

References 6 publications

Intralenticular Ozurdex® – One Year Later

Intralenticular Ozurdex® – One Year Later

Head‐to‐head comparison of ranibizumab PRN versus single‐dose dexamethasone for branch retinal vein occlusion (COMRADE‐B)

A review of the role of ultrasound biomicroscopy in glaucoma associated with rare diseases of the anterior segment

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