From Synthesis to Biological Impact of Pd (II) Complexes: Synthesis, Characterization, and Antimicrobial and Scavenging Activity

Abstract

The Pd (II) complexes with a series of halosubstituted benzylamine ligands (BLs) have been synthesized and characterized with different spectroscopic technique such as FTIR, UV/Vis, LCMS, 1H, and 13C NMR. Their molecular sustainability in different solvents such as DMSO, DMSO : H2O, and DMSO : PBS at physiological condition (pH 7.2) was determined by UV/Vis spectrophotometer. The in vitro antibacterial and antifungal activities of the complexes were investigated against Gram-positive and Gram-negative microbes and two different fungi indicated their significant biological potential. Additionally, their antioxidant activity has been analyzed with DPPH• free radical through spectrophotometric method and the result inferred them as an antioxidant. The stronger antibacterial and antioxidant activities of the synthesized complexes suggested them as a stronger antimicrobial agent. Our study advances the biological importance of palladium (II) amine complexes in the field of antimicrobial and antioxidant activities.

Co(III) based surfactant complexes and their Dye, BSA and free radical activities

“…Antioxidant or scavenging activities were determined on the basis of a free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging effect [18, 19, 20, 21, 22, 23, 24, 25]. Stock solution of DPPH (0.002%) was prepared with DMSO.…”

Pd(II) Complexes of Chiral Proline-Derived Ligands: Application for Dynamic Thermodynamic Resolution of α-Amino Acids and Their Antibacterial Activities

“…38−40 Pd(II) complex is a suitable candidate for metallopharmaceuticals due to its similar structural and biological properties as platinum, as well as relatively higher solubility along with lower side effects. 41 The biological evaluation of Pd(II) complexes has been an area of increasing interest. 42−45 Herein, we presented a novel DTR of racemic N,Cunprotected α-amino acids via Pd(II) complexes (Scheme 2a).…”

“…Infectious diseases caused by bacteria seriously threaten human health. Although the existing antibiotics are the mainstay to treat bacterial infections, their irrational use leads to the emergence and spread of multidrug resistance, which has caused a dramatic increase in global morbidity and mortality. − Therefore, there is a pressing medical need to develop novel antibacterial agents, among which metallopharmaceuticals may have substantial potential as an alternative therapeutic strategy. − Unlike most antibacterial drugs, which exert their antibacterial effects through a single mechanism, metal complexes play their antibacterial roles in microbes through multiple pathways such as enzyme inhibition, generation of reactive oxygen species, induction of cell cycle arrest, and intracellular biomolecular interaction. − Pd­(II) complex is a suitable candidate for metallopharmaceuticals due to its similar structural and biological properties as platinum, as well as relatively higher solubility along with lower side effects . The biological evaluation of Pd­(II) complexes has been an area of increasing interest. − …”

Manufacture and characterization of indicator electrodes from PPy + H2SO4 and PPy + Sulfonic acid as a urea sensor using urease enzyme immobilization technique in PVA

“…Fig.1, shows the analysis of the indicator electrode with UV-vis[8][9][10][11] on GA solution[2] and o-NPOE solution in PVC-KTpClPB (PVC-KTpClPB-o-NPOE)[1,[16][17][18]. The absorbance spectrum pattern with respect to the wavenumber of both shows a widening of the absorbance spectrum pattern for both GA and PVC-KTpClPB-o-NPOE.…”