Transsynaptic Retrograde Degeneration: Clinical Evidence with Homonymous RGCL Loss on OCT

Meier, P. G.; Maeder, Philippe; Borruat, F.-X.

doi:10.1055/s-0041-111535

Cited by 8 publications

(7 citation statements)

References 8 publications

(15 reference statements)

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“…We present a case of a visual field defect of postchiasmal origin, corresponding to neurosurgical intervention for a ruptured aneurysm secondary to an arteriovenous malformation. The OCT findings in our case are consistent with the literature in showing transsynaptic retinal degeneration from a posterior visual pathway insult (1–7). The patient also had a left homonymous hemianopia with corresponding thinning of the macular GCL and ppRNFL (2,3).…”

supporting

confidence: 92%

Transsynaptic Vascular Hypoperfusion in the Retina of a Patient With a Post-chiasmal Lesion and Homonymous Hemianopia

Eadie

Mishra²,

Betsch³

et al. 2022

Journal of Neuro-Ophthalmology

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supporting

confidence: 92%

Transsynaptic Vascular Hypoperfusion in the Retina of a Patient With a Post-chiasmal Lesion and Homonymous Hemianopia

Eadie

Mishra²,

Betsch³

et al. 2022

Journal of Neuro-Ophthalmology

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“…5 Previous studies in the literature demonstrated that abnormalities of macula GCC occurred earlier than peripapillary RNFL thickness. 15,[22][23][24] Moreover, the interpretation of GCC thinning and related visual field loss is easier. It has a simple mirror-image relationship with the visual field, in contrast to the complex relationship between RNFL bundles and visual field sectors that have been mapped previously.…”

Section: Discussionmentioning

confidence: 99%

Direct and transsynaptic retrograde degeneration and optic nerve head microvascular changes in patients with hemianopia

Büyüktepe

Kızıltunç

Büyüktepe

et al. 2020

European Journal of Ophthalmology

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Purpose: To investigate optic nerve head (ONH) microvascular changes secondary to transsynaptic retrograde degeneration (TRD), comperatively with direct retrograde degeneration and healthy controls. Methods: Patients with hemianopia due to intracranial lesion included in the study. Intracranial lesion was categorized by location: postgeniculate (causing TRD), chiasmal (causing direct retrograde degeneration). For the postgeniculate lesions, the eye on the same side of the lesion was defined as the ipsilateral eye and the eye on the opposite side as the contralateral eye. Optic disc microvasculature was evaluated with the help of optic coherence tomography angiography. Results: Sixteen eyes of 16 patients with chiasmal lesion, 28 eyes of 14 patients with postgeniculate lesion, and 30 eyes of 30 healthy subjects were included in the study. Ipsilateral eyes of the patients with postgeniculate lesion had decreased vessel density at the temporal sectors compatible with the affected nasal side of the visual field. Contralateral eyes showed no reduction of the vessel density at the affected nasal sectors. The eyes with chiasmal lesions had decreased vessel density at the peripapillary region and nasal half of the ONH compatible with temporal hemianopia. Vascular changes in the chiasmal lesion were more prominent than those of the postgeniculate lesion. Retinal nerve fiber layer and ganglion cell complex thickness were reduced. Conclusion: Vessel density of ONH was reduced in patients with homonymous hemianopia, providing evidence for TRD secondary to acquired postgeniculate lesion. Direct retrograde degeneration was more prominent in affected sectors when compared to TRD.

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“…The authors explained that in the earlier stage of compression, the conduction block corresponding to ganglion cell axons leads to an enlarged appearance on the peripapillary RNFL, and as the compression persists, the axonal damage may result in progressive RNFL thinning. 19,20 In the current study, the coexistence of RNFL thinning and thickening in different peripapillary quadrants might be related to different stages of the same neurodegeneration process in retinal nerve fibers. 18 The elevated intracranial pressure (ICP) is linked to compressive or ischemic effects on optic nerve.…”

Section: Discussionmentioning

confidence: 59%

“…Besides, a few studies reported significant GC-IPL thinning in brain lesions affecting pre-geniculate or post-geniculate optic pathways which were associated with transsynaptic retrograde degeneration of nerve fibers. 7,16,19 (Figure 5(a)-(d)). In the current study, the sectoral based GC-IPL analysis of inner and outer ring revealed contradictory results between eyes with intracranial tumors associated with pre-geniculate and post-geniculate optic pathway.…”

Section: Reported Thatmentioning

confidence: 99%

How do intracranial tumors associated with visual pathways affect quadrant and sectoral based optical coherence tomography measurements: The effect of intracranial tumors on RNFL and GC-IPL thickness

Özcan

Talıpınar

Kayıran

et al. 2021

European Journal of Ophthalmology

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Aim: To investigate the quantitative sectoral and regional changes of retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness in different types of intracranial tumors associated with visual pathways. Methods: This comparative retrospective study included 58 eyes of 30 patients with intracranial tumors and the data of 62 eyes of 31 healthy subjects. The RNFL and GCIPL thicknesses were analyzed using spectral-domain optical coherence tomography (OCT). The tumors were classified into ones that affect pre-geniculate and post-geniculate pathway Results: The mean RNFL thickness in temporal quadrant was significantly thinner in eyes with intracranial tumors affecting the pre-geniculate optic pathway compared to controls ( p = 0.04). In contrast, the mean superior quadrant RNFL thickness was significantly thicker in eyes with brain tumors associated with post-geniculate optic pathway ( p = 0.01). The mean GC-IPL thicknesses of the inner ring superotemporal, superonasal, inferotemporal and inferionasal sectors and outer ring superonasal and inferonasal sectors were significantly thinner in eyes with intracranial tumors affecting the pre-geniculate optic pathway compared to control eyes ( p = 0.02, p = 0.001, p = 0.02, p = 0.003, p = 0.008 and p = 0.03 respectively). Conclusion: The results of this study showed that significant changes can be seen in the different RNFL quadrants and GC-IPL sectors in eyes with intracranial tumors affecting pre-geniculate or post-geniculate optic pathway. OCT is a very useful imaging technique to quantify these structural changes which take place during the neurodegeneration process of visual pathways in intracranial tumors.

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Transsynaptic Retrograde Degeneration: Clinical Evidence with Homonymous RGCL Loss on OCT

Abstract: The homonymous defect of RGCL in patients with retrogeniculate lesions demonstrates the presence of transsynaptic retrograde degeneration. RGCL is a better predictor of visual field defects than RNFL measurement.

Cited by 8 publications

References 8 publications

Transsynaptic Vascular Hypoperfusion in the Retina of a Patient With a Post-chiasmal Lesion and Homonymous Hemianopia

Transsynaptic Vascular Hypoperfusion in the Retina of a Patient With a Post-chiasmal Lesion and Homonymous Hemianopia

Direct and transsynaptic retrograde degeneration and optic nerve head microvascular changes in patients with hemianopia

How do intracranial tumors associated with visual pathways affect quadrant and sectoral based optical coherence tomography measurements: The effect of intracranial tumors on RNFL and GC-IPL thickness

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