Self-Reported Periodontitis and Incident Type 2 Diabetes among Male Workers from a 5-Year Follow-Up to MY Health Up Study

Miyawaki, Atsushi; Toyokawa, Satoshi; Inoue, Kazuo; Miyoshi, Yuji; Kobayashi, Yasuki

doi:10.1371/journal.pone.0153464

Cited by 27 publications

(31 citation statements)

References 31 publications

(49 reference statements)

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“…Figure 1 showed the searching and including process. Appendix Table S1 and S2 summarized the characteristics of 43 cross-sectional studies and 12 [62,23,[63][64][65][66][67][68]39,[69][70][71] cohort studies, respectively. All included cross-sectional studies and cohort studies were scored more than 3.…”

Section: Results Of Search and Characteristics Of Included Studiesmentioning

confidence: 99%

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Yuan

Liu

et al. 2019

Preprint

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ObjectivesTo systematically reviewing the epidemiologic relationship between periodontitis (PD) and type 2 diabetes mellitus (T2DM). Materials and MethodsFour electronic databases were searched up to December, 2018. Manual search including the reference lists of included studies and relevant journals. Observational studies evaluating the relationship between T2DM and PD were included. Meta-analyses were applied using STATA. ResultsA total of 53 observational studies were included. Pooled results of cross-sectional studies found the strength of association between these two diseases was very strong (OR=3.27, p=0.000). Adjusted T2DM prevalence was significantly higher in PD patients (OR=4.04, p=0.000) and vice versa (OR=1.58, p=0.000). T2DM patients had significantly worse periodontal status, reflected in a 0.61mm deeper periodontal pocket, a 0.89mm higher attachment loss and about 2 more lost teeth (all p=0.000). Results of cohort studies found T2DM could elevate 27% risk of developing PD (p=0.000).Glycemic control state of T2DM might result in different PD outcomes. Severe PD increased 53% of incident T2DM (p=0.000) and this result was stable. In contrast, the impact of mild PD on T2DM incidence (RR=1.28, p=0.007) was less robust. ConclusionsThere is an evident bidirectional relationship between T2DM and periodontitis. Further well-designed cohort studies are needed to confirm this. Clinical RelevanceBoth dentists and physicians need to be aware of this strong connection between PD and T2DM.Control these two diseases might benefit the prevention of the incidence of each other.

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Section: Results Of Search and Characteristics Of Included Studiesmentioning

confidence: 99%

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Yuan

Liu

et al. 2019

Preprint

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“…Very few prospective cohort studies have shown positive associations of baseline periodontitis with incident type 2 diabetes (Miyawaki et al, 2016; Chiu et al, 2015; Demmer et al, 2008). However, two recent reviews of clinical trials assessing the effect of periodontitis treatment on HbA1c levels among subjects with type 2 diabetes showed very modest reductions (Li et al, 2015; Simpson et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Systematic reviews of epidemiologic studies suggest a bidirectional association between type 2 diabetes and periodontitis (Borgnakke et al 2013). Very few prospective cohort studies have shown positive associations of baseline periodontitis with incident type 2 diabetes (Demmer et al 2008, Chiu et al 2015, Miyawaki et al 2016). However, two recent reviews of clinical trials assessing the effect of periodontitis treatment on HbA1c levels among subjects with type 2 diabetes showed very modest reductions (Li et al 2015, Simpson et al 2015.…”

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confidence: 99%

Cross‐sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis

Pérez

Muñoz

Andriankaja

et al. 2017

J Clinic Periodontology

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Aim This study assessed the associations of prediabetes and insulin resistance with bleeding on probing (BOP) and periodontitis among adults. Materials and methods We included 1,191 Hispanic adults aged 40-65 years, free of diabetes, enrolled in the San Juan Overweight Adults Longitudinal Study. Pre-diabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or impaired glycated hemoglobin. Impaired one-hour plasma glucose (1hPG) was defined as levels>155 mg/dL. Insulin resistance was defined using the study population-specific 75th percentile (HOMA-IR≥3.13). High BOP was defined as percentage of teeth with bleeding ≥30%. Periodontitis was defined according to the CDC/AAP definition. Results After multivariable adjustment for age, gender, education, smoking status, alcohol consumption, physical activity, obesity, HDL-C, and plaque index, prediabetes with and without 1hPG, IFG, impaired 1hPG, IGT, and HOMA-IR were significantly associated with high BOP; prediabetes, IFG, and impaired 1hPG were significantly associated with severe periodontitis. Most of these associations remained significant when the analyses were restricted to non-smokers. Conclusions This study suggests associations between prediabetes and insulin resistance with BOP and periodontitis. Given the high prevalence of impaired glucose metabolism and periodontitis, the assessment of the temporal sequence of these associations are of utmost importance.

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“…One study found only a tendency for increased risk (Ide et al 2011 concluded that there was "scant evidence" for periodontitis promoting the development of T2DM and recommended further studies in different populations. A more recent search of the literature reveals only a small number of further studies investigating periodontitis (Chiu et al 2015, Miyawaki et al 2016, or tooth loss (Liljestrand et al 2015) as risk factors for incident T2DM.…”

mentioning

confidence: 99%

Periodontitis and incident type 2 diabetes: a prospective cohort study

Winning

Patterson

Neville

et al. 2017

J Clinic Periodontology

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Objectives:To investigate periodontitis as a risk factor for incident type 2 diabetes mellitus (T2DM) in a group of men aged 58-72 years. Accepted ArticleThis article is protected by copyright. All rights reserved. Methods:1331 dentate, diabetes-free males in Northern Ireland underwent a detailed periodontal examination during [2001][2002][2003]. Follow-up was by bi-annual questionnaire and for those reporting diabetes their general medical practitioner was contacted to validate diabetes type, treatment and diagnosis date. Cox's proportional hazard models were used to estimate the effect of periodontitis on incident diabetes. Multivariable analysis included adjustment for various known confounders. Results:The mean age of the men was 63.7 (SD 3.0) years. There were 80 cases (6.0%) of incident T2DM. Follow-up was for a median period of 7.8 years ). After adjusting for confounding variables, the hazard ratio (HR) for incident T2DM in men with moderate / severe periodontitis versus those with no / mild periodontitis was 1.69 (95% CI 1.06-2.69), p=0.03. Conclusion:There was evidence in this homogenous group of dentate men, that those with moderate to severe periodontitis had a significantly increased risk of incident T2DM. Clinical Relevance Scientific rational for the study:Evidence supporting the role of chronic periodontitis as a putative risk factor for the development of type 2 diabetes mellitus (T2DM) is currently limited. Principal findings: Accepted ArticleThis article is protected by copyright. All rights reserved.This study showed that in a group of 58-72 year-old Caucasian dentate men in Northern Ireland, baseline moderate to severe periodontitis was an independent risk predictor for the development of T2DM. This relationship was independent of known confounders. Practical implications:Dentists should be aware of the potential systemic health implications of patients presenting with moderate to severe periodontitis. Patients who present with obvious risk factors for T2DM and signs of periodontitis should be informed about their risk for developing T2DM.

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Self-Reported Periodontitis and Incident Type 2 Diabetes among Male Workers from a 5-Year Follow-Up to MY Health Up Study

Cited by 27 publications

References 31 publications

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

Cross‐sectional associations of impaired glucose metabolism measures with bleeding on probing and periodontitis

Periodontitis and incident type 2 diabetes: a prospective cohort study

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