A Role for Tumor Volume Assessment in Resectable Esophageal Cancer

Tullie, Lucinda; Sohn, Hyon-Mok; Zylstra, Janine; Mattsson, Fredrik; Griffin, Nyree; Sharma, Naveen; Porté, François; Ramage, Lisa; Cook, Gary; Gossage, James; Mason, Robert C.; Lagergren, Jesper; Davies, Andrew

doi:10.1245/s10434-016-5228-x

Cited by 16 publications

(8 citation statements)

References 19 publications

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“…The ve value based on the DCE-MRI scans reflects the ratio of the volume of the contrast agent in the extravascular extracorporeal space, which is indicative of tumor proliferation. Tuillie et al have shown that when tumor grade increases, pathological tumor volume and cell density value also increase (22); meanwhile, Chen et al demonstrated that a higher ve value is associated with a higher tumor T stage (23). In the present study, the rate of tumor proliferation in the PR group was higher than that in the CR group; thus, the value of ve in the PR group was higher than that in the CR group.…”

Section: Discussionsupporting

confidence: 40%

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Diagnostic Performance of Vascular Permeability and Texture Parameters for Evaluating the Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma

Wang

Zhou

et al. 2021

Front. Oncol.

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BackgroundEsophageal squamous cell carcinoma (ESCC) is an aggressive type of cancer, associated with poor prognosis. The development of an accurate and non-invasive method to evaluate the pathologic response of patients with ESCC to chemoradiotherapy remains a critical issue. Therefore, the aim of this study was to assess the importance of vascular permeability and texture parameters in predicting the response to neoadjuvant chemoradiotherapy (NACRT) in patients with ESCC.MethodsThis prospective analysis included patients with T1–T2 stage of ESCC, without either lymphatic or metastasis, and distant metastasis. All patients underwent surgery having received two rounds of NACRT. All patients underwent dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) twice, i.e., before the first NACRT and after the second NACRT. Patients were assessed for treatment response at 30 days after the second NACRT. Patients were divided into the complete response (CR) and partial response (PR) groups based on their responses to NACRT. Vascular permeability and texture parameters were extracted from the DCE-MRI scans. After assessing the diagnostic performance of individual parameters, a combined model with vascular permeability and texture parameters was generated to predict the response to NACRT.ResultsIn this study, the CR and PR groups included 16 patients each. The volume transfer constant (Ktrans), extracellular extravascular volume fraction (ve), and entropy values, as well as changes to each of these parameters, extracted from the second DCE-MRI scans, showed significant differences between the CR and PR groups. The area under the curve (AUC) of Ktrans, ve, and entropy values showed good diagnostic ability (0.813, 0.789, and 0.707, respectively). A logistic regression model combining Ktrans, ve, and entropy had significant diagnostic ability (AUC=0.977).ConclusionsThe use of a combined model with vascular permeability and texture parameters can improve post-NACRT prognostication in patients with ESCC.

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Section: Discussionsupporting

confidence: 40%

“…Tuillie et al. have shown that when tumor grade increases, pathological tumor volume and cell density value also increase ( 22 ); meanwhile, Chen et al. demonstrated that a higher ve value is associated with a higher tumor T stage ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Vascular Permeability and Texture Parameters for Evaluating the Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma

Wang

Zhou

et al. 2021

Front. Oncol.

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“…With a background incidence of oesophageal cancer in Finland at the time of 4.3 per 100 000 they were only able to exclude a prevalence of oesophageal cancer in patients born with OA of greater than 500 times that of the background population. Of note, patients in the present analysis developed oesophageal cancer at a younger age (median 40.5 years) than the general population, where the median age at diagnosis is around 64 years 79 .…”

Section: Discussionmentioning

confidence: 61%

Barrett’s oesophagus and oesophageal cancer following oesophageal atresia repair: a systematic review

et al. 2021

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Background Concern exists that patients born with oesophageal atresia (OA) may be at high risk for Barrett’s oesophagus (BO), a known malignant precursor to the development of oesophageal adenocarcinoma. Screening endoscopy has a role in early BO identification but is not universal in this population. This study aimed to determine prevalence of BO after OA repair surgery, to quantify the magnitude of this association and inform the need for screening and surveillance. Methods A systematic review, undertaken according to PRISMA guidelines, was preregistered on PROSPERO (CRD42017081001). PubMed and EMBASE were interrogated using a standardized search strategy on 31 July 2020. Included papers, published in English, reported either: one or more patients with either BO (gastric/intestinal metaplasia) or oesophageal cancer in patients born with OA; or long-term (greater than 2 years) follow-up after OA surgery with or without endoscopic screening or surveillance. Results Some 134 studies were identified, including 19 case reports or series and 115 single- or multi-centre cohort studies. There were 13 cases of oesophageal cancer (9 squamous cell carcinoma, 4 adenocarcinoma) with a mean age at diagnosis of 40.5 (range 20–47) years. From 6282 patients under long-term follow-up, 317 patients with BO were reported. Overall prevalence of BO was 5.0 (95 per cent c.i. 4.5 to 5.6) per cent, with a mean age at detection of 13.8 years (range 8 months to 56 years). Prevalence of BO in series reporting endoscopic screening or surveillance was 12.8 (95 per cent c.i. 11.3 to 14.5) per cent. Conclusion Despite a limited number of cancers, the prevalence of BO in patients born with OA is relatively high. While limited by the quality of available evidence, this review suggests endoscopic screening and surveillance may be warranted, but uncertainties remain over the design and effectiveness of any putative programme.

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“…GTVp was then found to be an independent prognostic factor for OS and PFS. Recently, several studies have reported a close association between survival outcome and tumor volume in EC [ 19 , 20 ], but the optimal cut-off points of GTVp varied among studies. Créhange et al [ 7 ] initially found that the optimal cut-off point for differences in OS was 100 cm3.…”

Section: Discussionmentioning

confidence: 99%

Primary gross tumor volume is prognostic and suggests treatment in upper esophageal cancer

et al. 2021

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Background To aid clinicians strategizing treatment for upper esophageal squamous cell carcinoma (ESCC), this retrospective study investigated associations between primary gross tumor volume (GTVp) and prognosis in patients given surgical resection, radiotherapy, or both resection and radiotherapy. Methods The population comprised 568 patients with upper ESCC given definitive treatment, including 238, 216, and 114 who underwent surgery, radiotherapy, or combined radiotherapy and surgery. GTVp as a continuous variable was entered into the multivariate Cox model using penalized splines (P-splines) to determine the optimal cutoff value. Propensity score matching (PSM) was used to adjust imbalanced characteristics among the treatment groups. Results P-spline regression revealed a dependence of patient outcomes on GTVp, with 30 cm3 being an optimal cut-off for differences in overall and progression-free survival (OS, PFS). GTVp ≥30 cm3 was a negative independent prognostic factor for OS and PFS. PSM analyses confirmed the prognostic value of GTVp. For GTVp < 30 cm3, no significant survival differences were observed among the 3 treatments. For GTVp ≥30 cm3, the worst 5-year OS rate was experienced by those given surgery. The 5-year PFS rate of patients given combined radiotherapy and surgery was significantly better than that of patients given radiotherapy. The surgical complications of patients given the combined treatment were comparable to those who received surgery, but radiation side effects were significantly lower. Conclusion GTVp is prognostic for OS and PFS in upper ESCC. For patients with GTVp ≥30 cm3, radiotherapy plus surgery was more effective than either treatment alone.

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A Role for Tumor Volume Assessment in Resectable Esophageal Cancer

Abstract: Tumor volume may predict survival, margin status, and lymph node positivity after surgery for esophageal cancer.

Cited by 16 publications

References 19 publications

Diagnostic Performance of Vascular Permeability and Texture Parameters for Evaluating the Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma

Diagnostic Performance of Vascular Permeability and Texture Parameters for Evaluating the Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma

Barrett’s oesophagus and oesophageal cancer following oesophageal atresia repair: a systematic review

Primary gross tumor volume is prognostic and suggests treatment in upper esophageal cancer

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