Period of Hyperbaric Oxygen Delivery Leads to Different Degrees of Hepatic Ischemia/Reperfusion Injury in Rats

Chaves, José Carlos; Neto, Frederico Somaio; Ikejiri, Adauto Tsutomu; Bertoletto, Paulo Roberto; Teruya, Roberto; Simões, Ricardo Santos; Tikazawa, Eduardo Hiroshi; Liu, J.B.; Carrara, F.; Taha, Murched Omar; Fagundes, Djalma José

doi:10.1016/j.transproceed.2015.11.035

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…Hepatic IR injury in rats was induced according to the previously described methods (Ali et al, 2015;Chaves et al, 2016). Rats were anesthetized with ketamine (100 mg/kg, i.p.)…”

Section: Surgical Proceduresmentioning

confidence: 99%

Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF‐κB‐p65/TLR‐4, JAK1/STAT‐3, Nrf‐2, and PI3K/Akt/mTOR Signaling Pathways

Kamel

Hassanein

Ahmed

et al. 2019

The Anatomical Record

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Hepatic ischemia reperfusion (IR) is an inevitable clinical problem for surgical procedures such as liver transplantation and liver resection. This study was designed to evaluate the protective effect of perindopril (PER) against hepatic IR injury. Thirty‐two rats were used and randomly allocated into four groups. Sham control group was subjected to sham operation and received saline only, IR group was subjected to IR and received vehicle, PER group was pretreated with PER (one milligram per kilogram per day i.p. for 10 consecutive days), and IR+PER group was pretreated with PER then subjected to IR. Liver function biomarkers (aspartate aminotransferase and alanine aminotransferase), oxidative stress (glutathione, malondialdehyde, myeloperoxidase, and superoxide dismutase) and inflammation markers (tumor necrosis factor‐alpha, interferon‐gamma, and inteleukin‐10 [IL‐10]), mRNA expression of NF‐κB‐p65 and TLR‐4, as well as protein expression of JAK1, STAT‐3, PI3K, mTOR, Akt, and Nrf‐2 were investigated concomitantly with histopathological examination. The results indicated that, hepatic IR induced a significant alteration in liver function biomarkers and structure, oxidative stress, and inflammation. At the molecular level, up‐regulation of NF‐κB‐p65, TLR‐4, JAK1, and STAT‐3 concomitantly with down‐regulation of Nrf‐2, IL‐10, PI3K, Akt, and mTOR were observed. These disturbances were alleviated by pretreatment of IR rats with PER in concomitant with hepatic structural improvement. Conclusively, the protective effect of PER presumably may be relevant to its ability to reduce oxidative stress, ameliorate the inflammatory processes, and modify the related signaling pathways. Anat Rec, 2019. © 2019 American Association for Anatomy Anat Rec, 303:1935–1949, 2020. © 2019 American Association for Anatomy

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“…Hepatic IR injury in rats was induced according to the previously described methods (Ali et al, 2015;Chaves et al, 2016). Rats were anesthetized with ketamine (100 mg/kg, i.p.)…”

Section: Surgical Proceduresmentioning

confidence: 99%

Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF‐κB‐p65/TLR‐4, JAK1/STAT‐3, Nrf‐2, and PI3K/Akt/mTOR Signaling Pathways

Kamel

Hassanein

Ahmed

et al. 2019

The Anatomical Record

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“…Besides, the therapeutic effect of HBOT in different periods of I/R was determined. And studies showed that HBOT subjected to early during ischemia played a more favorable effect compared to be subjected to both periods of ischemia and reperfusion; otherwise, HBOT given in the period of reperfusion was associated with a more severe hepatocyte apoptosis and liver damage 13 , 14 . Yet the protection of HBOT in hepatic I/R injury still remains controversial.…”

Section: Hbot In Acute Liver Injurymentioning

confidence: 99%

Hyperbaric Oxygen Therapy in Liver Diseases

et al. 2018

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Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve progress of lots of diseases especially hypoxia-related injuries, and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning, decompression sickness, arterial gas embolism, problematic wound, and so on. In the liver, most studies positively evaluated HBOT as a potential therapeutic option for liver transplantation, acute liver injury, nonalcoholic steatohepatitis, fibrosis and cancer, especially for hepatic artery thrombosis. This might mainly attribute to the anti-oxidation and anti-inflammation of HBOT. However, some controversies are existed, possibly due to hyperbaric oxygen toxicity. This review summarizes the current understandings of the role of HBOT in liver diseases and hepatic regeneration. Future understanding of HBOT in clinical trials and its in-depth mechanisms may contribute to the development of this novel adjuvant strategy for clinical therapy of liver diseases.

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“…Some studies have confirmed that HBO is protective on liver I/R injury (Baldim et al, 2013;Silveira et al, 2014). However, Chaves et al (Chaves, 2009(Chaves, , 2016 found the effects of HBO on liver I/R injury were dependent on the time of HBO administration: A favorable effect was obtained when HBO was administered early during ischemia, but HBO given in later periods of reperfusion was associated with a more severe sum index percentage of liver damage.…”

Section: Rationale For the Clinical Application Of Hbo In Liver Transmentioning

confidence: 99%

Application of hyperbaric oxygen in liver transplantation

Han

Sun

et al. 2016

Med Gas Res

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In recent years, hyperbaric oxygen (HBO) has been used in the treatment of a lot of diseases such as decompression sickness, arterial gas embolism, carbon dioxide poisoning, soft tissue infection, refractory osteomyelitis, and problematic wound, but little is known about its application in liver transplantation. Although several studies have been conducted to investigate the protective effects of HBO on liver transplantation and liver preservation, there are still some controversies on this issue, especially its immunomodulatory effect. In this short review, we briefly summarize the findings supporting the application of HBO during liver transplantation (including donors and recipients).

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Period of Hyperbaric Oxygen Delivery Leads to Different Degrees of Hepatic Ischemia/Reperfusion Injury in Rats

Cited by 8 publications

References 13 publications

Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF‐κB‐p65/TLR‐4, JAK1/STAT‐3, Nrf‐2, and PI3K/Akt/mTOR Signaling Pathways

Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF‐κB‐p65/TLR‐4, JAK1/STAT‐3, Nrf‐2, and PI3K/Akt/mTOR Signaling Pathways

Hyperbaric Oxygen Therapy in Liver Diseases

Application of hyperbaric oxygen in liver transplantation

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