Preliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli

“…[Howell et al, ]. Local field potential recordings from the GPi in humans showed correlation between pallidal LFP amplitude and reward expectation [Schroll et al, ].…”

Section: Introductionmentioning

confidence: 99%

“…These findings have recently been corroborated in humans. Howell et al identified GPi neurons in Parkinson's patients that modulate their firing rate significantly in response to reward-related stimuli [Howell et al, 2016]. Local field potential recordings from the GPi in humans showed correlation between pallidal LFP amplitude and reward expectation [Schroll et al, 2015].…”

Section: Introductionmentioning

confidence: 99%

The human subthalamic nucleus and globus pallidus internus differentially encode reward during action control

Rossi

Peden

Castellanos

et al. 2017

Human Brain Mapping

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The subthalamic nucleus (STN) and globus pallidus internus (GPi) have recently been shown to encode reward, but few studies have been performed in humans. We investigated STN and GPi encoding of reward and loss (i.e., valence) in humans with Parkinson's disease. To test the hypothesis that STN and GPi neurons would change their firing rate in response to reward- and loss-related stimuli, we recorded the activity of individual neurons while participants performed a behavioral task. In the task, action choices were associated with potential rewarding, punitive, or neutral outcomes. We found that STN and GPi neurons encode valence-related information during action control, but the proportion of valence-responsive neurons was greater in the STN compared to the GPi. In the STN, reward-related stimuli mobilized a greater proportion of neurons than loss-related stimuli. We also found surprising limbic overlap with the sensorimotor regions in both the STN and GPi, and this overlap was greater than has been previously reported. These findings may help to explain alterations in limbic function that have been observed following deep brain stimulation therapy of the STN and GPi. Hum Brain Mapp 38:1952-1964, 2017. © 2017 Wiley Periodicals, Inc.

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“…Preclinical evidence has highlighted reward‐related behaviors of GPi lateral habenula‐projecting neurons (10% of the structure) . Human GPi single neurons exhibited selective phasic increases in firing rate associated with reward information . Clinical reports have associated abulia and anhedonia as well as apathy with unilateral and bilateral lesions to the GP .…”

Section: Why Did Functional Stereotactic Surgery Start With the Pallimentioning

confidence: 99%

“…87,88 Human GPi single neurons exhibited selective phasic increases in firing rate associated with reward information. 89 Clinical reports have associated abulia and anhedonia as well as apathy with unilateral and bilateral lesions to the GP. 90,91 Clinically and experimentally observed deficits in motivation and reward-related behavior were reversed after administration of dopaminergic medications.…”

Section: Nonmotor Functions Of the Gpimentioning

confidence: 99%

Seventy years of pallidotomy for movement disorders

Cif

Hariz

2017

Movement Disorders

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The year 2017 marks the 70th anniversary of the birth of human stereotactic neurosurgery. The first procedure was a pallidotomy for Huntington's disease. However, it was for Parkinson's disease that pallidotomy was soon adopted worldwide. Pallidotomy was abandoned in the late 1950s in favor of thalamotomy because of the latter's more striking effect on tremor. The advent of levodopa put a halt to all surgery for PD. In the mid-1980s, Laitinen reintroduced the posteroventral pallidotomy of Leksell, and this procedure spread worldwide thanks to its efficacy on most parkinsonian symptoms including levodopa-induced dyskinesias and thanks to basic scientific work confirming the role of the globus pallidus internus in the pathophysiology of PD. With the advent of deep brain stimulation of the subthalamic nucleus, pallidotomy was again abandoned, and even DBS of the GPi has been overshadowed by STN DBS. The GPi reemerged in the late 1990s as a major stereotactic target for DBS in dystonia and, recently, in Tourette syndrome. Lately, lesioning of the GPI is being proposed to treat refractory status dystonicus or to treat DBS withdrawal syndrome in PD patients. Hence, the pallidum as a stereotactic target for either lesioning or DBS has been the phoenix of functional stereotactic neurosurgery, constantly abandoned and then rising again from its ashes. This review is a tribute to the pallidum on its 70th anniversary as a surgical target for movement disorders, analyzing its ebbs and flows and highlighting its merits, its versatility, and its resilience. © 2017 International Parkinson and Movement Disorder Society.

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Preliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli

Abstract: HighlightsNon-motor responses of human GPi neurons are described.Cells were identified that showed increased firing to reward-stimuli.Visual-sensory responses unrelated to reward also observed.

Cited by 22 publications

References 57 publications

Impulsivity in Parkinson’s disease is associated with altered subthalamic but not globus pallidus internus activity

Impulsivity in Parkinson’s disease is associated with altered subthalamic but not globus pallidus internus activity

The human subthalamic nucleus and globus pallidus internus differentially encode reward during action control

Seventy years of pallidotomy for movement disorders

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