Smartphones Can Monitor Medical Center Pneumatic Tube Systems

Mullins, Garrett R.; Harrison, J. Hartwell; Bruns, David E.

doi:10.1373/clinchem.2016.257063

Cited by 12 publications

(3 citation statements)

References 10 publications

(9 reference statements)

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“…Previously, acceleration during pneumatic transportation of blood samples has been suggested to affect laboratory results [5,7,14,15]. The combined three-axis effect of accelerations, expressed as area under the curve (AUC), has been found to correlate with PTS speed and to exhibit a direct relation to the degree of hemolysis [5].…”

Section: Introductionmentioning

confidence: 99%

Use of clinical data and acceleration profiles to validate pneumatic transportation systems

Gils

Broell²,

Vinholt

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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BackgroundModern pneumatic transportation systems (PTSs) are widely used in hospitals for rapid blood sample transportation. The use of PTS may affect sample integrity. Impact on sample integrity in relation to hemolysis and platelet assays was investigated and also, we wish to outline a process-based and outcome-based validation model for this preanalytical component.MethodsThe effect of PTS was evaluated by drawing duplicate blood samples from healthy volunteers, one sent by PTS and the other transported manually to the core laboratory. Markers of hemolysis (potassium, lactate dehydrogenase [LD] and hemolysis index [HI]) and platelet function and activation were assessed. Historic laboratory test results of hemolysis markers measured before and after implementation of PTS were compared. Furthermore, acceleration profiles during PTS and manual transportation were obtained from a mini g logger in a sample tube.ResultsHand-carried samples experienced a maximum peak acceleration of 5 g, while peaks at almost 15 g were observed for PTS. No differences were detected in results of potassium, LD, platelet function and activation between PTS and manual transport. Using past laboratory data, differences in potassium and LD significantly differed before and after PTS installation for all three lines evaluated. However, these estimated differences were not clinically significant.ConclusionsIn this study, we found no evidence of PTS-induced hemolysis or impact on platelet function or activation assays. Further, we did not find any clinically significant changes indicating an acceleration-dependent impact on blood sample quality. Quality assurance of PTS can be performed by surveilling outcome markers such as HI, potassium and LD.

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Section: Introductionmentioning

confidence: 99%

Use of clinical data and acceleration profiles to validate pneumatic transportation systems

Gils

Broell²,

Vinholt

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Within our own hospital for instance, blood products are transported to different floors of the hospital via PTS, likely producing variations in the forces the cargo experiences. Several prior publications encompassing different hospital systems have measured peak accelerations of approximately 8g, [57] to 15 g, [58], with peak accelerations of up to 25g having been reported in a study that evaluating higher speeds not routinely used for blood product transport (7 m/s). [15] This variance may explain some of the heterogeneity in reports of the effects of PTS on blood products.…”

Section: Discussionmentioning

confidence: 99%

Effect of Pneumatic Tubing System Transport on Platelet Apheresis Units

Zilberman‐Rudenko

Zhao

Reitsma

et al. 2018

Cardiovasc Eng Tech

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Platelet apheresis units are transfused into patients to mitigate or prevent bleeding. In a hospital, platelet apheresis units are transported from the transfusion service to the healthcare teams via two methods: a pneumatic tubing system (PTS) or ambulatory transport. Whether PTS transport affects the activity and utility of platelet apheresis units is unclear. We quantified the gravitational forces and transport time associated with PTS and ambulatory transport within our hospital. Washed platelets and supernatants were prepared from platelet apheresis units prior to transport as well as following ambulatory or PTS transport. For each group, we compared resting and agonist-induced platelet activity and platelet aggregate formation on collagen or von Willebrand factor (VWF) under shear, platelet VWF-receptor expression and VWF multimer levels. Subjection of platelet apheresis units to rapid acceleration/deceleration forces during PTS transport did not pre-activate platelets or their ability to activate in response to platelet agonists as compared to ambulatory transport. Platelets within platelet apheresis units transported via PTS retained their ability to adhere to surfaces of VWF and collagen under shear, although platelet aggregation on collagen and VWF was diminished as compared to ambulatory transport. VWF multimer levels and platelet GPIb receptor expression was unaffected by PTS transport as compared to ambulatory transport. Subjection of platelet apheresis units to PTS transport did not significantly affect the baseline or agonist-induced levels of platelet activation as compared to ambulatory transport. Our case study suggests that PTS transport may not significantly affect the hemostatic potential of platelets within platelet apheresis units.

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“…Sample transport conditions should be described and include as a minimum, details on the transit time, temperature, exposure to mechanical forces e.g. if samples have been transported via pneumatic tube systems [15].…”

Section: Preanalytical Conditions (Conditions Prior To the Basal Timementioning

confidence: 99%

The CRESS checklist for reporting stability studies: on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE)

Cornes

Šimundić

Cadamuro

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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To ensure that clinical laboratories produce results that are both accurate and of clinical utility it is essential that only samples of adequate quality are analysed. Although various studies and databases assessing the stability of analytes in different settings do exist, guidance on how to perform and report stability studies is lacking. This results in studies that often do not report essential information, thus compromising transferability of the data. The aim of this manuscript is to describe the Checklist for Reporting Stability Studies (CRESS) against which future studies should be reported to ensure standardisation of reporting and easy assessment of transferability of studies to other healthcare settings. The EFLM WG-PRE (European Federation of Clinical Chemistry and Laboratory Medicine Working Group for the Preanalytical Phase) produced the CRESS checklist following a detailed literature review and extensive discussions resulting in consensus agreement. The checklist consists of 20 items covering all the aspects that should be considered when producing a report on a stability study including details of what should be included for each item and a rationale as to why. Adherence to the CRESS checklist will ensure that studies are reported in a transparent and replicable way. This will allow other laboratories to assess whether published data meet the stability criteria required in their own particular healthcare scenario. The EFLM WG-PRE encourage researchers and authors to use the CRESS checklist as a guide to planning stability studies and to produce standardised reporting of future stability studies.

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Smartphones Can Monitor Medical Center Pneumatic Tube Systems

Cited by 12 publications

References 10 publications

Use of clinical data and acceleration profiles to validate pneumatic transportation systems

Use of clinical data and acceleration profiles to validate pneumatic transportation systems

Effect of Pneumatic Tubing System Transport on Platelet Apheresis Units

The CRESS checklist for reporting stability studies: on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE)

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