The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size

Christensen, Alex Hørby; Chatelain, Franck C.; Huttner, Inken G.; Olesen, Morten S.; Soka, Magdalena; Féliciangéli, Sylvain; Horvat, Claire; Santiago, Celine; Vandenberg, Jamie I.; Schmitt, Nicole; Olesen, Søren-Peter; Lesage, Florian; Fatkin, Diane

doi:10.1016/j.yjmcc.2016.04.006

Cited by 32 publications

(53 citation statements)

References 41 publications

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“…It has been also reported that TWIK-1 conducts inward leak Na + currents during pathological hypokalemia in cardiomyocytes [ 11 ]. Interestingly, TWIK-1 knock-down zebrafish showed bradycardia and atrial dilation, which is consistent with atrial fibrillation identified in human TWIK-1 variants [ 12 ]. These previous observations strongly suggest the important physiological roles of TWIK-1 channels.…”

Section: Introductionsupporting

confidence: 75%

Emerging Roles of TWIK-1 Heterodimerization in the Brain

Cho

Hwang

Park

2017

IJMS

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Two-pore domain K+ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K+ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain.

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Section: Introductionsupporting

confidence: 75%

Emerging Roles of TWIK-1 Heterodimerization in the Brain

Cho

Hwang

Park

2017

IJMS

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“…It was initially reported that TWIK-1 (also called cTBAK-1) is expressed more strongly in human ventricular myocytes than in atrial myocytes based on RT-PCR and Northern blot analysis [ 1 , 38 ]. However, TWIK-1 was later reported to be more intensely expressed in the atrium than in the ventricle [ 39 , 40 , 41 ], and it also seems to be expressed strongly in Purkinje fibers [ 42 ]. In murids, very strong expression of TWIK-1 was found in the whole rat heart, as confirmed by single-cell RT-PCR of both atrial and ventricular myocytes [ 29 , 43 ].…”

Section: Two-pore Domain In a Weak Inward Rectifying K+ Channel (Twik)mentioning

confidence: 99%

Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology

Herrera-Pérez

Campos-Ríos

Rueda‐Ruzafa

et al. 2021

IJMS

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Years before the first two-pore domain potassium channel (K2P) was cloned, certain ion channels had already been demonstrated to be present in the heart with characteristics and properties usually attributed to the TREK channels (a subfamily of K2P channels). K2P channels were later detected in cardiac tissue by RT-PCR, although the distribution of the different K2P subfamilies in the heart seems to depend on the species analyzed. In order to collect relevant information in this regard, we focus here on the TWIK, TASK and TREK cardiac channels, their putative roles in cardiac physiology and their implication in coronary pathologies. Most of the RNA expression data and electrophysiological recordings available to date support the presence of these different K2P subfamilies in distinct cardiac cells. Likewise, we show how these channels may be involved in certain pathologies, such as atrial fibrillation, long QT syndrome and Brugada syndrome.

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“…Nevertheless, these studies using human atrial tissue have provided important insight into the molecular mechanisms underlying AF. Most of the published work points towards similar pathways through which atrial remodeling occurs: ion channel alteration [125][126][127][128][129], contractile dysfunction [130], increased oxidative stress [131], development of cardiac fibrosis [132][133][134][135], increased risk of thromboembolic events [128,132,136] and inflammation [137] . However, when examining the degree of overlap of differentially expressed genes identified in the various studies, it is unexpectedly small (Figure 3, Table 1).…”

Section: Transcriptomics In Afmentioning

confidence: 99%

Functional genomics and epigenomics of atrial fibrillation

Victorino

Alvarez-Franco

Manzanares

2021

Journal of Molecular and Cellular Cardiology

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The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size

Cited by 32 publications

References 41 publications

Emerging Roles of TWIK-1 Heterodimerization in the Brain

Emerging Roles of TWIK-1 Heterodimerization in the Brain

Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology

Functional genomics and epigenomics of atrial fibrillation

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