Investigation of Hungarian mushrooms for antibacterial activity and synergistic effects with standard antibiotics against resistant bacterial strains

Liktor‐Busa, Erika; Kovacs, Beatrix; Urbán, Edit; Hohmann, Judit; Ványolós, Attila

doi:10.1111/lam.12576

Cited by 19 publications

(18 citation statements)

References 22 publications

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“…[22]. Moreover, the crude extract showed high synergistic effects in combination with cefuroxime against MRSA [116,125].…”

Section: Fistulina Hepatica (Schaeff)mentioning

confidence: 94%

“…), commonly known as beefsteak fungus, is a wild edible fungus belonging to the family Fistulinaceae [95]. It is distributed in temperate and subtropical hardwood forests of China, Thailand, Hungary, Portugal [4,58,115,116], and other European countries. Two novel triacetylene derivatives have been isolated from the fruiting bodies and named cinnatriacetins A (37) and B (38) [117].…”

Section: Fistulina Hepatica (Schaeff)mentioning

confidence: 99%

“…A methanol/water (80:20) extract of F. hepatica collected in Portugal inhibited the growth of gram-negative (Escherichia coli, Morganella morganni and Pasteurella multocida) and gram-positive (Staphylococcus aureus, MRSA, Enterococcus faecalis, Listeria monocytogenes, Streptococcus agalactiae and Streptococcus pyogenes) bacteria [22]. Moreover, the crude extract showed high synergistic effects in combination with cefuroxime against MRSA [116,125]. [22].…”

Section: Fistulina Hepatica (Schaeff)mentioning

confidence: 99%

“…(Fistulinaceae) Extract [115,118,119] Cinnatriacetins A (37) and B (38) [117]. Extract [22,116,125] -- Lactarius hatsudake Nobuj. Tanaka (Russulaceae) ---Ergosterol peroxide, 5α,8α-epidioxy-(24S)-ergosta -6-en-3β-ol (antiphospholipase A 2 activity [139] and anti-HIV activity [140])…”

Section: Thelephora Ganbajun M Zangmentioning

confidence: 99%

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Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

et al. 2020

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Mushrooms have a long history of uses for their medicinal and nutritional properties. They have been consumed by people for thousands of years. Edible mushrooms are collected in the wild or cultivated worldwide. Recently, mushroom extracts and their secondary metabolites have acquired considerable attention due to their biological effects, which include antioxidant, antimicrobial, anti-cancer, anti-inflammatory, anti-obesity, and immunomodulatory activities. Thus, in addition to phytochemists, nutritionists and consumers are now deeply interested in the phytochemical constituents of mushrooms, which provide beneficial effects to humans in terms of health promotion and reduction of disease-related risks. In recent years, scientific reports on the nutritional, phytochemical and pharmacological properties of mushroom have been overwhelming. However, the bioactive compounds and biological properties of wild edible mushrooms growing in Southeast Asian countries have been rarely described. In this review, the bioactive compounds isolated from 25 selected wild edible mushrooms growing in Southeast Asia have been reviewed, together with their biological activities. Phytoconstituents with antioxidant and antimicrobial activities have been highlighted. Several evidences indicate that mushrooms are good sources for natural antioxidants and antimicrobial agents

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“…[22]. Moreover, the crude extract showed high synergistic effects in combination with cefuroxime against MRSA [116,125].…”

Section: Fistulina Hepatica (Schaeff)mentioning

confidence: 94%

Section: Fistulina Hepatica (Schaeff)mentioning

confidence: 99%

Section: Fistulina Hepatica (Schaeff)mentioning

confidence: 99%

Section: Thelephora Ganbajun M Zangmentioning

confidence: 99%

See 2 more Smart Citations

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

et al. 2020

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“…In our search for higher mushrooms with antibacterial activity we previously demonstrated that several species native to Hungary exerted notable activity on Gram-positive and negative bacteria. Among these the extracts of Tapinella atrotomentosa (Batsch) Šutara revealed not only a broad-spectrum antimicrobial activity on Gram-positive and negative pathogens, but demonstrated also a significant inhibitory activity against resistant bacterial strains [ 2 ]. T. atrotomentosa —velvet rollrim by its vernacular name—is a wood-rotting mushroom belonging to the Tapinellaceae family.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa

et al. 2018

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Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1–3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity.

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Evaluation of Bio-detoxification of Jatropha curcas Seed Cake and Cottonseed Cake by Basidiomycetes: Nutritional and Antioxidant Effects

Guimarães

Siqueira

Campanha

et al. 2021

Waste Biomass Valor

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Poultry and swine are the major proportion of the livestock industry in terms of output value. To meet the growing need for protein sources in these sectors, the use of biomasses coming from agro-industrial residues can be an interesting option in the coming years. This study aimed to evaluate the capacity of seven basidiomycetes to grow, detoxicate, increase protein content, and also its antioxidant activity when grew in pure Jatropha seed cake (JSC) and cottonseed cake (CSC) biomasses and mixtures containing 50% of lignocellulosic biomasses from coconut husks and Acrocomia aculeata (macauba cake). Results showed that ve basidiomycetes were able to grow in these substrates. F. hepatica, P. lecomtei, and P. pulmonarius presented the highest bio-detoxi cation capacity. All treatments showed a reduction in total phenolic compounds (TPC) and antioxidant activity, but treatments with coconut husks showed lower reductions. Results also indicated that there are molecules produced by basidiomycetes responsible for antioxidant activity other than phenolic compounds. These results indicated that basidiomycetes could detoxify JCS and CSC biomasses, suggesting their possible use in animal feed and that the addition of coconut husks in JSC and macauba cake in cottonseed cake can promote greater colonization by fungi. Statement Of NoveltyGlobally, there is an increasing demand for sustainable protein sources for animal feed. The use of agroindustrial wastes appears as a viable, economic and ecological alternative. In this context biomasses from Jatropha curcas seed cake (JSC), cottonseed cake (CSC). However, JSC and CSC contain toxic compounds that can impair animals' digestibility. Bio-detoxi cation with macro-fungi is a cheap and e cient process to reduce the concentration of these substances and improve protein content, besides generating edible mushrooms and lignocellulosic enzymes. Our work evaluated the colonization of seven different basidiomycetes in pure and mixed biomasses with lignocellulosic agro-industrial wastes aiming to select a suitable one for animal feed, focusing on reducing producer's cost and avoiding environmental disposal.young ruminants and monogastric animals [2]. As an alternative to enable the use of these biomasses, colonization with macrofungi (basidiomycetes) offers the advantages of being a low-cost process to biodetoxicate these substrates and also the production of value-added products, such as edible mushrooms and lignocellulosic enzymes [3]. Besides, the cultivation of mushrooms in agro-industrial wastes can improve their protein content, produce bioactive molecules such as phenolic compounds, polysaccharides, sterols, and reduce lignin and cellulose content, improving their digestibility for animal feed [4]. A good balance of carbon-nitrogen is important to promote the better growth of fungi [5]. So, the combination of Jatropha or cottonseed cakes as protein sources, and coconut husks or Acrocomia aculeata (Jacq.) Lodd. ex Mart. (palm) cakes as carbohydrates source, is interesting for basi...

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Investigation of Hungarian mushrooms for antibacterial activity and synergistic effects with standard antibiotics against resistant bacterial strains

Cited by 19 publications

References 22 publications

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa

Evaluation of Bio-detoxification of Jatropha curcas Seed Cake and Cottonseed Cake by Basidiomycetes: Nutritional and Antioxidant Effects

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